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Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes.

Abstract：

:Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecular form of polyphenol mixture, typically catechin-type monomers and oligomers of proanthocyanidins, which are produced by an oligomerization process. Although previous studies reported anti-inflammatory properties of Oligonol, it is unknown whether and how Oligonol suppresses IL-6 and TNF-α production in human monocytes. The results of our study demonstrate that Oligonol (25μg/ml) decreases the production of IL-6 and TNF-α from human primary monocytes as measured by flow cytometry and ELISA. Such an anti-cytokine effect was likely mediated by the suppression of NF-κB activation without inducing cell death. Our findings raise the possibility of exploring the benefits of Oligonol in controlling inflammatory conditions, especially those associated with monocytes, in humans.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Lee N,Shin MS,Kang Y,Park K,Maeda T,Nishioka H,Fujii H,Kang I

doi

10.1016/j.humimm.2016.04.011

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

512-5

issue

6

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(16)30052-0

journal_volume

77

pub_type

杂志文章

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