Abstract:
:Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculosis on human dendritic cells. Previous studies reported inconsistent results on the association between CD209 polymorphisms and TB. We examined whether 9 single nucleotide polymorphisms (SNPs) of CD209 are associated with TB in 2 southeast Asian populations (Indonesian and Vietnamese) by Fisher's exact test. The SNP at -939 in the promoter region exhibited a significant association with TB in Indonesian (GG vs GA + AA, p = 0.0051, odds ratio [OR] = 0.68, 95% confidence interval [CI] = 0.52-0.89) but not in Vietnamese populations. Further extensive studies are required to confirm the contribution of CD209 polymorphisms to TB susceptibility.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Kobayashi K,Yuliwulandari R,Yanai H,Lien LT,Hang NT,Hijikata M,Keicho N,Tokunaga Kdoi
10.1016/j.humimm.2011.04.004subject
Has Abstractpub_date
2011-09-01 00:00:00pages
741-5issue
9eissn
0198-8859issn
1879-1166pii
S0198-8859(11)00094-2journal_volume
72pub_type
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