Estimation of optimal donor number in Bone Marrow Donor Registry: Hong Kong's experience.

abstract：:The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...

journal_title：Human immunology

authors： Demaria S,Bushkin Y

更新日期：2000-12-01 00:00:00

abstract：:Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant re...

journal_title：Human immunology

authors： Holder AL,Wolf S,Walshe C,Pandya P,Stanford RE,Smith JD,Rose ML,Lawson C

更新日期：2008-02-01 00:00:00

abstract：:Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. Hereditary etiology has been proposed as a cause of the sarcoidosis, and some Human Leucocyte Antigen (HLA) alleles have been related to the diagnosis or severity of the disease. Löfgren's syndrome has been linked to patients with the DRB1*03 all...

journal_title：Human immunology

authors： da Costa CH,Silva VL,Fabricio-Silva GM,Usnayo M,Rufino R,Porto LC

更新日期：2013-10-01 00:00:00

abstract：:A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...

journal_title：Human immunology

authors： Kishi H,Okumura A,Tong JJ,Sugiyama E,Matsuno H,Minowada J,Kanai T,Nishimura Y,Muraguchi A

更新日期：1997-08-01 00:00:00

abstract：:Virus-specific T cells have been shown to cross-react with allogeneic HLA (allo-HLA) at a clonal level. However, the impact of a single virus on the allorepertoire has never been investigated at the polyclonal level. We made an inventory of the incidence and specificity of allo-HLA-cross-reactive-virus-specific CD8+ T...

journal_title：Human immunology

authors： van den Heuvel H,van der Meer-Prins EMW,van Miert PPMC,Zhang X,Anholts JDH,Claas FHJ

更新日期：2019-02-01 00:00:00

abstract：:Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) w...

journal_title：Human immunology

authors： Potekhina AV,Provatorov SI,Sokolov VO,Pylaeva EA,Masenko VP,Noeva EA,Kukhtina NB,Krasnikova TL,Arefieva TI

更新日期：2011-07-01 00:00:00

abstract：:An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...

journal_title：Human immunology

authors： Gomez-Casado E,Martinez-Laso J,Vargas-Alarcón G,Varela P,Diaz-Campos N,Alvarez M,Alegre R,Arnaiz-Villena A

更新日期：1997-04-15 00:00:00

abstract：:HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of...

journal_title：Human immunology

authors： Obata F,Endo T,Yoshii M,Otani F,Igarashi M,Takenouchi T,Ikeda H,Ogasawara K,Kasahara M,Wakisaka A

更新日期：1985-09-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

journal_title：Human immunology

authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

更新日期：2010-02-01 00:00:00

abstract：:Signal transducer and activator of transcription 4 (STAT4) has been recently identified as a susceptibility gene for multiple autoimmune diseases. Here we performed a comprehensive analysis of the association between STAT4 and several different autoimmune disorders to identify potential common inflammatory principles ...

journal_title：Human immunology

authors： Zheng J,Yin J,Huang R,Petersen F,Yu X

更新日期：2013-08-01 00:00:00

abstract：:Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...

journal_title：Human immunology

authors： Li C,Jiang Y,Guo W,Liu Z

更新日期：2013-05-01 00:00:00

abstract：:Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...

journal_title：Human immunology

authors： Lucotte G,Gérard N,Mercier G

更新日期：2001-09-01 00:00:00

abstract：:CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...

journal_title：Human immunology

authors： Chen Q,Yuan S,Sun H,Peng L

更新日期：2019-03-01 00:00:00

abstract：:The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

journal_title：Human immunology

authors： Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

更新日期：1989-05-01 00:00:00

abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

journal_title：Human immunology

authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

更新日期：2018-02-01 00:00:00

abstract：:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...

journal_title：Human immunology

authors： Levitsky V,Liu D,Southwood S,Levitskaya J,Sette A,Masucci MG

更新日期：2000-10-01 00:00:00

abstract：:MUC1 mucin, primarily known as an epithelial antigen, has been demonstrated to be expressed on activated human T cells. In the present study, we first examined the expression of MUC1 on different subsets of T cells (naive, effector, effector/memory). MUC1 appears to be strongly upregulated on activated CD4(+) T cells ...

journal_title：Human immunology

authors： Konowalchuk JD,Agrawal B

更新日期：2012-05-01 00:00:00

abstract：:Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopo...

journal_title：Human immunology

authors： Nestorowicz K,Bogacz A,Bukowska A,Chraplak M,Czerwiński J,Góralski M,Gronkowski M,Jopek K,Kniżewski Ł,Kolasiński M,Kowalski ML,Nowak J,Sowiński M,Wróblewska-Kabba S,Tymoniuk B,Dudkiewicz M

更新日期：2020-01-01 00:00:00

abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...

journal_title：Human immunology

authors： Dave VP,Larché M,Rencher SD,Koop BF,Hurwitz JL

更新日期：1993-07-01 00:00:00

abstract：:Six murine monoclonal antibodies raised against sheep MHC class II molecules were analyzed for reactivity with HLA-D subregion products. All the antibodies reacted with human peripheral blood lymphocytes, monocytes, and B-lymphoblastoid cell lines homozygous for various HLA-DR specificities, suggesting that the antibo...

journal_title：Human immunology

authors： Puri NK,de Kretser T,Brandon MR

更新日期：1987-11-01 00:00:00

abstract：:Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculo...

journal_title：Human immunology

authors： Kobayashi K,Yuliwulandari R,Yanai H,Lien LT,Hang NT,Hijikata M,Keicho N,Tokunaga K

更新日期：2011-09-01 00:00:00

abstract：:The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...

journal_title：Human immunology

authors： Carbonara AO,DeMarchi M,van Loghem E,Ansaldi N

更新日期：1983-02-01 00:00:00

abstract：:It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nuc...

journal_title：Human immunology

authors： Świątek-Kościelna B,Kałużna E,Strauss E,Januszkiewicz-Lewandowska D,Bereszyńska I,Wysocki J,Rembowska J,Barcińska D,Antosik D,Mozer-Lisewska I,Nowak J

更新日期：2017-02-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...

journal_title：Human immunology

authors： Bonfigli S,Fozza C,Contini S,Buzzetti R,Cucca F,Longinotti M

更新日期：2007-05-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G polymorphisms are associated with human papillomavirus (HPV) infection susceptibility and persistence in 636 female university students in Montreal. HLA-...

journal_title：Human immunology

authors： Ferguson R,Ramanakumar AV,Richardson H,Tellier PP,Coutlée F,Franco EL,Roger M

更新日期：2011-04-01 00:00:00

abstract：:In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...

journal_title：Human immunology

authors： Herrera M,Chertkoff L,Palavecino E,Mota A,Guala MC,Fainboim L,Satz ML

更新日期：1989-12-01 00:00:00

abstract：:The expression of the Duffy Antigen/Receptor for Chemokines (DARC) on red blood cells (RBC) has been commonly determined using hemagglutination tests. Because the vast majority of African individuals are Duffy-negative, screening for DARC expression on RBC is a valuable tool to assess Caucasian admixture in population...

journal_title：Human immunology

authors： Nickel RG,Willadsen SA,Freidhoff LR,Huang SK,Caraballo L,Naidu RP,Levett P,Blumenthal M,Banks-Schlegel S,Bleecker E,Beaty T,Ober C,Barnes KC

更新日期：1999-08-01 00:00:00

abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

journal_title：Human immunology

authors： Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

更新日期：2013-05-01 00:00:00

abstract：:The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...

journal_title：Human immunology

authors： Zuniga J,Romero V,Azocar J,Stern JN,Clavijo O,Almeciga I,Encinales L,Avendano A,Fridkis-Hareli M,Pandey JP,Yunis EJ

更新日期：2006-11-01 00:00:00

abstract：:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...

journal_title：Human immunology

authors： Elliott SR,Macardle PJ,Roberton DM,Zola H

更新日期：1999-11-01 00:00:00