Abstract:
:Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G polymorphisms are associated with human papillomavirus (HPV) infection susceptibility and persistence in 636 female university students in Montreal. HLA-G*01:01:02 and HLA-G*01:01:08 alleles were associated with increased risk of HPV-16 (odds ratio (OR) = 2.10, 95% confidence interval (CI), 1.11-3.96) and any infections with HPV types from α species 1, 8, 10, and 13 (OR = 2.72, 95% CI, 1.11-6.68). HLA-G*01:01:02 and HLA-G*01:03 alleles were associated with persistent HPV-16 (OR = 2.07, 95% CI, 1.16-3.68) and persistent infections with HPV types from α species 2, 3, 4, and 15 (OR = 2.99, 95% CI, 1.12-8.00). HLA-E polymorphism was not associated with risk of acquisition or persistence of HPV infection. These results suggest that HLA-G molecules may play a role in mediating HPV infection risk.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Ferguson R,Ramanakumar AV,Richardson H,Tellier PP,Coutlée F,Franco EL,Roger Mdoi
10.1016/j.humimm.2011.01.010subject
Has Abstractpub_date
2011-04-01 00:00:00pages
337-41issue
4eissn
0198-8859issn
1879-1166pii
S0198-8859(11)00018-8journal_volume
72pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.11.003
更新日期:2007-04-01 00:00:00
abstract::Based upon observations in murine models, we have developed protocols to induce renal allograft tolerance by combined kidney and bone marrow transplantation (CKBMT) in non-human primates (NHP) and in humans. Induction of persistent mixed chimerism has proved to be extremely difficult in major histocompatibility comple...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2017.11.008
更新日期:2018-05-01 00:00:00
abstract::Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.02.005
更新日期:2017-04-01 00:00:00
abstract::A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2004.02.012
更新日期:2004-05-01 00:00:00
abstract::CD8-positive γδ T lymphocytes (GDCD8(+)) are specifically increased in peripheral blood of Behçet's disease (BD) patients. GDCD8(+) have shown a T regulatory (Treg) function in autoimmune experimental models, human tumor infiltrates and intestinal intraepithelial lymphocytes from celiac patients. The aim of this study...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.10.001
更新日期:2016-01-01 00:00:00
abstract::In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common fals...
journal_title:Human immunology
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.humimm.2012.03.014
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The aims of this study were to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of asthma and to generate SNP to gene to pathway hypotheses. METHODS:SNPs that met a threshold of p ≤ 0.001 in a genome-wide association study (GWAS) dataset of asthma, which in...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.11.003
更新日期:2013-02-01 00:00:00
abstract::TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00361-5
更新日期:2002-01-01 00:00:00
abstract::Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.01.002
更新日期:2013-05-01 00:00:00
abstract::Rearrangements of the T-cell Rearranging Gene (TRG) or T-cell-receptor gamma-chain genes were analyzed in 24 in vivo-sensitized alloreactive T-cell clones. This analysis represents the first complete assignment of TRG gene rearrangements to given variable and joining gene segments in nonleukemic T cells and provides s...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90050-5
更新日期:1989-02-01 00:00:00
abstract::A panel of 34 clones was established from a cell line derived from the skin biopsy of a patient (genotype: A1, A2, B7, B8, DR3, DR6) undergoing acute graft-versus-host disease after semiallogeneic bone marrow transplantation with his mother's bone marrow (genotype: A1, A1, B7, B8, DR3, DR6). The T-cell line obtained p...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90074-y
更新日期:1990-10-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine whether the TLR2-R753Q, TLR4-D299G, TLR4-T399I common polymorphisms are associated with susceptib...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.05.004
更新日期:2009-09-01 00:00:00
abstract::Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.12.008
更新日期:2007-03-01 00:00:00
abstract::Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.05.005
更新日期:2006-09-01 00:00:00
abstract::Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.03.002
更新日期:2009-06-01 00:00:00
abstract::The human major histocompatibility complex includes a group of non-classical HLA class I genes, HLA-E, -F and -G. While nearly all focus since the discovery of these class Ib molecules have been on basic biochemistry and molecular biology of HLA-G and HLA-E, as well as their expression patterns, functions in immune mo...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2019.09.006
更新日期:2020-04-01 00:00:00
abstract::MUC1 mucin, primarily known as an epithelial antigen, has been demonstrated to be expressed on activated human T cells. In the present study, we first examined the expression of MUC1 on different subsets of T cells (naive, effector, effector/memory). MUC1 appears to be strongly upregulated on activated CD4(+) T cells ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.02.024
更新日期:2012-05-01 00:00:00
abstract::To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. Significant increase ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90113-f
更新日期:1993-02-01 00:00:00
abstract::The HLA-B5,B35 cross-reacting group is a large and serologically complex antigen family which includes the World Health Organization-recognized specificities HLA-B5,B51,Bw52,B35,Bw53,B18,Bw70,Bw71, and Bw72. In addition, several variants of antigens in this cross-reacting group have been described in the past but have...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90035-9
更新日期:1989-11-01 00:00:00
abstract::Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90033-5
更新日期:1989-09-01 00:00:00
abstract::The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00254-8
更新日期:2001-03-01 00:00:00
abstract::The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90046-r
更新日期:1990-03-01 00:00:00
abstract::We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent ha...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.07.286
更新日期:2020-09-01 00:00:00
abstract::The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.11.005
更新日期:2017-02-01 00:00:00
abstract::The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.04.004
更新日期:2016-11-01 00:00:00
abstract::Celiac disease (CD) patients are intolerant to gluten, proteins in wheat, and related cereals. Virtually all patients are human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positive and several studies have demonstrated that CD4 T cells specific for (modified) gluten peptides bound to these HLA-DQ molecules are found in pat...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2006.03.011
更新日期:2006-06-01 00:00:00
abstract::Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.09.005
更新日期:2004-12-01 00:00:00
abstract::We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specifi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00119-6
更新日期:1999-12-01 00:00:00
abstract::Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.05.011
更新日期:2011-10-01 00:00:00