Celiac disease--sandwiched between innate and adaptive immunity.

Abstract:

:Celiac disease (CD) patients are intolerant to gluten, proteins in wheat, and related cereals. Virtually all patients are human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positive and several studies have demonstrated that CD4 T cells specific for (modified) gluten peptides bound to these HLA-DQ molecules are found in patients but not in control subjects. These T cell responses are therefore thought to be responsible for disease development. Many immunogenic gluten peptides which may relate to the disease-inducing properties of gluten have now been identified. In addition, gluten can stimulate IL-15 production that ultimately leads to NKG2D-mediated epithelial cell killing. However, CD develops in only a minority of HLA-DQ2 and HLA-DQ8 individuals. This may be attributed to the default setting of the intestinal immune system: induction and maintenance of tolerance to dietary components and commensal flora. Although at present it is unknown why tolerance in CD is not established or broken, both environmental and genetic factors have been implicated. There is strong evidence for the existence of genes or gene variants on chromosomes 5, 6, and 19 that predispose to CD. In addition, type I interferons have been implicated in development of several autoimmune disorders, including CD. Thus, viral infection and/or tissue damage in the intestine may cause inflammation and induce protective Th1-mediated immunity leading to loss of tolerance for gluten. Once tolerance is broken, a broad gluten-reactive T cell repertoire may develop through determinant spreading. This may be a critical step toward full-blown disease.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Stepniak D,Koning F

doi

10.1016/j.humimm.2006.03.011

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

460-8

issue

6

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(06)00051-6

journal_volume

67

pub_type

杂志文章,评审
  • The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura.

    abstract::The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2016.11.005

    authors: Sinkovits G,Szilágyi Á,Farkas P,Inotai D,Szilvási A,Tordai A,Rázsó K,Réti M,Prohászka Z

    更新日期:2017-02-01 00:00:00

  • A method for using serum or plasma as a source of DNA for HLA typing.

    abstract::A simple method for obtaining DNA from serum and plasma is described. Using appropriate primer pairs the polymorphic segments of HLA class II genes were amplified by the polymerase chain reaction (PCR) from this DNA, and typed using allele-specific oligonucleotide hybridization. When compared with DNA obtained from pe...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(92)90060-z

    authors: Martin M,Carrington M,Mann D

    更新日期:1992-02-01 00:00:00

  • Increased expressions of CD69 and HLA-DR but not of CD25 or CD71 on endometrial T lymphocytes of nonpregnant women.

    abstract::To investigate lymphocyte subpopulations and the status of T-cell activation at different phases of the menstrual cycle, lymphocytes in endometrial tissue were analyzed by dual-color flow cytometry in 39 patients. Compared with peripheral blood, the lymphocytes in the endometrium had a higher CD3-/(CD56+ or CD16+) rat...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(94)00105-y

    authors: Chen CK,Huang SC,Chen CL,Yen MR,Hsu HC,Ho HN

    更新日期:1995-03-01 00:00:00

  • HLA-restricted immune response to mycobacterial antigens: relevance to vaccine design.

    abstract::Identification of mycobacterial antigens that are recognized by CD4+ Th1 cells in HLA-nonrestricted manner or in association with multiple allelic products is required to develop universally effective vaccines against mycobacterial diseases. Our studies in this direction have shown that several recombinant mycobacteri...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(99)00137-8

    authors: Mustafa AS

    更新日期:2000-02-01 00:00:00

  • HLA-A11-mediated protection from NK cell-mediated lysis: role of HLA-A11-presented peptides.

    abstract::The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(96)00031-6

    authors: Gavioli R,Zhang QJ,Masucci MG

    更新日期:1996-08-01 00:00:00

  • Impact on mid-term kidney graft outcomes of pretransplant anti-HLA antibodies detected by solid-phase assays: Do donor-specific antibodies tell the whole story?

    abstract::The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2017.07.011

    authors: Malheiro J,Tafulo S,Dias L,Martins S,Fonseca I,Beirão I,Castro-Henriques A,Cabrita A

    更新日期:2017-09-01 00:00:00

  • HLA and complement factors alleles sharing in Italian couples with recurrent spontaneous abortions.

    abstract::Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(98)00028-7

    authors: Pennesi G,Brioli G,Lulli P,Mariani B,Morellini M,Nicotra M,Trabace S

    更新日期:1998-06-01 00:00:00

  • Characterization of HLA class I specific antibodies by ELISA using solubilized antigen targets: I. Evaluation of the GTI QuikID assay and analysis of antibody patterns.

    abstract::The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(00)00254-8

    authors: Zachary AA,Delaney NL,Lucas DP,Leffell MS

    更新日期:2001-03-01 00:00:00

  • High dose chemotherapy and autologous hematopoietic stem cell transplantation for rheumatoid arthritis: a review.

    abstract::A new treatment approach, involving intense immunosuppression and autologous hematopoietic stem cell transplantation (SCT), has emerged in recent years for the treatment of severe, refractory rheumatic autoimmune diseases including rheumatoid arthritis (RA). The rationale of this strategy is based on the concept of im...

    journal_title:Human immunology

    pub_type: 杂志文章,评审

    doi:10.1016/s0198-8859(02)00414-7

    authors: Verburg Ro,Toes RE,Fibbe WE,Breedveld FC,van Laar JM

    更新日期:2002-08-01 00:00:00

  • North African genes in Iberia studied by Y-chromosome DNA haplotype V.

    abstract::Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(01)00287-7

    authors: Lucotte G,Gérard N,Mercier G

    更新日期:2001-09-01 00:00:00

  • DNA sequence analysis of the HLA-DRw12 allele.

    abstract::The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(89)90069-4

    authors: Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

    更新日期:1989-05-01 00:00:00

  • Concomitant augmentation of type 1 CD4+ and CD8+ T-cell responses during successful interferon-alpha and ribavirin treatment for chronic hepatitis C virus infection.

    abstract::The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(03)00041-7

    authors: Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

    更新日期:2003-05-01 00:00:00

  • Inverse association of peripheral blood CD4(+) invariant natural killer T cells with atopy in human asthma.

    abstract::Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2009.10.011

    authors: Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

    更新日期:2010-02-01 00:00:00

  • Why do we have the kidney allocation system we have today? A history of the 2014 kidney allocation system.

    abstract::"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...

    journal_title:Human immunology

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.humimm.2016.08.008

    authors: Stegall MD,Stock PG,Andreoni K,Friedewald JJ,Leichtman AB

    更新日期:2017-01-01 00:00:00

  • Monoclonal and xenoantibodies specific for HLA-DR inhibit primary responses to HLA-D but fail to inhibit secondary proliferative (PLT) responses to allogeneic cells.

    abstract::Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(81)90050-1

    authors: Eckels DD,Woody JN,Hartzman RJ

    更新日期:1981-10-01 00:00:00

  • CTLA-4 polymorphism and clinical outcome post allogeneic hematopoietic stem cell transplantation.

    abstract::CTLA-4 inhibitory molecule plays an important role in regulating T cell activation. It is considered a crucial element in keeping the immune balance and has been implicated in cancer, autoimmunity and transplantation immunology. Inconsistent observations are reported regarding its association with hematopoietic stem c...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2013.08.002

    authors: Mossallam GI,Samra MA

    更新日期:2013-12-01 00:00:00

  • Description of a new HLA-E (E*01031) allele and its frequency in the Spanish population.

    abstract::An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(97)00008-6

    authors: Gomez-Casado E,Martinez-Laso J,Vargas-Alarcón G,Varela P,Diaz-Campos N,Alvarez M,Alegre R,Arnaiz-Villena A

    更新日期:1997-04-15 00:00:00

  • Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco.

    abstract::To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlant...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(01)00370-6

    authors: Oumhani K,Canossi A,Piancatelli D,Di Rocco M,Del Beato T,Liberatore G,Aureli A,Benjoaud A,El Aouad R,Adorno D,Casciani CU

    更新日期:2002-02-01 00:00:00

  • Epigenetics and pathogenesis of systemic sclerosis; the ins and outs.

    abstract::The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...

    journal_title:Human immunology

    pub_type: 杂志文章,评审

    doi:10.1016/j.humimm.2018.01.003

    authors: Aslani S,Sobhani S,Gharibdoost F,Jamshidi A,Mahmoudi M

    更新日期:2018-03-01 00:00:00

  • Impact of pronase on flow cytometric crossmatch outcome.

    abstract::Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2011.01.005

    authors: Hetrick SJ,Schillinger KP,Zachary AA,Jackson AM

    更新日期:2011-04-01 00:00:00

  • Functional impact of A91V mutation of the PRF1 perforin gene.

    abstract::Perforin (PRF1) gene mutations have been associated with Familial Hemophagocytic Lymphohistiocytosis type 2 (FHL2). Substitution p.A91V (c.272C>T) in exon 2 was first described as a neutral polymorphism. Nonetheless, recent clinical evidence and functional assays, suggest a potential pathogenic role for p.A91V, especi...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2012.10.011

    authors: Martínez-Pomar N,Lanio N,Romo N,Lopez-Botet M,Matamoros N

    更新日期:2013-01-01 00:00:00

  • Alloantibodies in heart transplantation.

    abstract::The presence of complement fixing anti-human leukocyte antigen (HLA) antibodies in the circulation of organ transplant recipients may result in heart allograft rejection. Here, we assessed the clinical impact of pre- and post-transplantation allosensitization on long-term survival of heart allografts. Sequential sampl...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2009.06.015

    authors: Ho EK,Vlad G,Colovai AI,Vasilescu ER,Schwartz J,Sondermeijer H,Burke E,Marboe CC,Itescu S,Suciu-Foca N,Mancini D

    更新日期:2009-10-01 00:00:00

  • Monoclonal antibodies to sheep MHC class II molecules recognize all HLA-D or subsets of HLA-D region products.

    abstract::Six murine monoclonal antibodies raised against sheep MHC class II molecules were analyzed for reactivity with HLA-D subregion products. All the antibodies reacted with human peripheral blood lymphocytes, monocytes, and B-lymphoblastoid cell lines homozygous for various HLA-DR specificities, suggesting that the antibo...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/0198-8859(87)90103-0

    authors: Puri NK,de Kretser T,Brandon MR

    更新日期:1987-11-01 00:00:00

  • CR1 levels and gene polymorphisms exhibit differential association with falciparum malaria in regions of varying disease endemicity.

    abstract::Complement receptor 1 (CR1/CD35) levels on erythrocytes and related CR1 polymorphisms have been associated with response to falciparum malaria in populations inhabiting malaria-endemic regions. Differences in disease association profiles of its low expression alleles have been observed in populations from different re...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2009.02.001

    authors: Sinha S,Jha GN,Anand P,Qidwai T,Pati SS,Mohanty S,Mishra SK,Tyagi PK,Sharma SK,Venkatesh V,Habib S

    更新日期:2009-04-01 00:00:00

  • A murine monoclonal antibody (928) recognizing a new epitope formed with a combination of HLA-DPA1*0201 and DPB1*0301 gene products.

    abstract::A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(97)00143-2

    authors: Kishi H,Okumura A,Tong JJ,Sugiyama E,Matsuno H,Minowada J,Kanai T,Nishimura Y,Muraguchi A

    更新日期:1997-08-01 00:00:00

  • Identification of a microRNA signature in dendritic cell vaccines for cancer immunotherapy.

    abstract::Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2009.10.001

    authors: Holmstrøm K,Pedersen AW,Claesson MH,Zocca MB,Jensen SS

    更新日期:2010-01-01 00:00:00

  • Identification of sequence variants in the CCL3 chemokine gene family in the HapMap West African reference population.

    abstract::Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2014.06.009

    authors: Perry RT,Nyaku MK,Aissani B,Shrestha S

    更新日期:2014-08-01 00:00:00

  • T-cell receptor bias in patients with allergic bronchopulmonary aspergillosis.

    abstract::CD4(+) Th2 helper cell mediated immune responses have been shown to play a crucial role in the pathogenesis of ABPA. HLA and TCR are the candidate genes, which can influence the specificity of these responses. We have previously established a strong association of HLA DR2/5 in ABPA susceptibility. The study was design...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(02)00361-0

    authors: Chauhan B,Hutcheson PS,Slavin RG,Bellone CJ

    更新日期:2002-04-01 00:00:00

  • The association of class I HLA alleles and antibody levels after a single dose of measles vaccine.

    abstract::Despite the success of the current measles vaccine in controlling disease in industrialized countries, the importance of vaccine failure has become increasingly apparent. Our objective was to determine if associations exist between seronegativity after measles vaccination and class I human leukocyte antigen (HLA) alle...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/s0198-8859(02)00741-3

    authors: Jacobson RM,Poland GA,Vierkant RA,Pankratz VS,Schaid DJ,Jacobsen SJ,Sauver JS,Moore SB

    更新日期:2003-01-01 00:00:00

  • IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells.

    abstract::Dendritic cells play an important role in the initiation of immune reactions. Due to their high capacity to prime T-cell responses, the activation of dendritic cells must be tightly controlled. Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate hum...

    journal_title:Human immunology

    pub_type: 杂志文章

    doi:10.1016/j.humimm.2018.06.002

    authors: Michelini S,Sarajlic M,Duschl A,Horejs-Hoeck J

    更新日期:2018-08-01 00:00:00