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HLA class II-restricted binding of muramyl peptides to B lymphocytes of normal and narcoleptic subjects.

Abstract：

:The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, naturally occurring bacterial cell wall peptidoglycans, potently enhance the duration and amplitude of slow-wave sleep in animals, bind to murine mononuclear cells, and exhibit a major histocompatibility complex-restricted immunoadjuvant effect in mice. We examined the binding of muramyl peptides to peripheral blood mononuclear leukocytes of HLA-typed normal (n = 13) and narcoleptic (n = 10) subjects. Muramyl peptides bound specifically and with high affinity to normal B- but not T-lymphocyte-enriched preparations. There was no significant specific binding to B-cell-enriched preparations from narcoleptic patients. Furthermore, B-lymphocyte-enriched preparations of normal individuals who had the HLA-DR2,DQw1 phenotype (n = 8) exhibited a lower level of specific binding than those of normals who did not have this phenotype (n = 5, p less than 0.001). These observations are an additional indication of the relevance of muramyl peptides to slow-wave sleep and provide a basis for a better understanding of the relation between narcolepsy and the MHC at the biochemical level.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Silverman DH,Sayegh MH,Alvarez CE,Johnson TS,Milford EL,Karnovsky ML

doi

10.1016/0198-8859(90)90046-r

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

145-54

issue

3

eissn

0198-8859

issn

1879-1166

pii

0198-8859(90)90046-R

journal_volume

27

pub_type

杂志文章

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