当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Discordant expression of HLA class II-associated co-chaperones and HLA-DRB alleles in cultured fibroblast-like synoviocytes.

Discordant expression of HLA class II-associated co-chaperones and HLA-DRB alleles in cultured fibroblast-like synoviocytes.

Abstract：

:Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB alleles are efficiently expressed by synovial fibroblasts is germane to this hypothesis. To address this, cultured fibroblast-like synoviocytes (cFLS) were analyzed for constitutive and interferon (IFN)-gamma-induced expression of specific DRB alleles and class II-associated cochaperones. IFN-gamma induction of invariant chain, DM, and DR molecules was observed in all cFLS, but expression of specific DR allotypes was variable. Interestingly, DM-modulated epitopes on RA-associated DR molecules were either absent or delayed, despite strong DM expression and a paucity of major histocompatibility complex/class II-associated invariant chain peptide complexes. Altered expression of specific peptide-dependent epitopes on RA-associated HLA-DR molecules suggests differences in antigen presentation by cFLS, which may have implications for the immunopathogenesis of RA.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Spurrell DR,Oldford SA,Frost T,Larsen B,Codner D,Edgecombe A,Drover S

doi

10.1016/j.humimm.2004.09.005

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1516-29

issue

12

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(04)00625-1

journal_volume

65

pub_type

杂志文章

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