当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Characterization of skin-infiltrating T lymphocytes during acute graft-versus-host disease.

Characterization of skin-infiltrating T lymphocytes during acute graft-versus-host disease.

Abstract：

:A panel of 34 clones was established from a cell line derived from the skin biopsy of a patient (genotype: A1, A2, B7, B8, DR3, DR6) undergoing acute graft-versus-host disease after semiallogeneic bone marrow transplantation with his mother's bone marrow (genotype: A1, A1, B7, B8, DR3, DR6). The T-cell line obtained presented the following phenotype: CD3+, CD4+, CD8-, CD16-, WT31+, T-cell receptor delta 1-, 4B4+, 2H4-, CD25+, DR+. This CD4+ T-cell line was poorly cytotoxic against the target cells tested, including the mother's phytohemagglutinin blasts as a negative control (autologous T cells), the father's phytohemagglutinin blasts bearing the mismatch haplotype, K562, U937, SVK14 (a keratinocyte cell line), and a panel of B-lymphoblastoid cell lines bearing HLA-A2, the known mismatch antigen. All but 1 of the 34 clones obtained were of CD4+ phenotype, and none was CD16+. Only the sole CD8+ clone showed significant cytotoxicity against the father's phytohemagglutinin blast; however, this cytotoxic activity was associated with the highest score for nonspecific killing against both K562 and U937. This work demonstrates the feasibility of obtaining a large panel of clones from a graft-versus-host disease target organ to constitute the basic cellular material for in vitro study of the graft-versus-host process.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Vié HP,Millpied N,Devilder MC,Mahe B,Hallet MM,Moreau JF,Soulillou JP

doi

10.1016/0198-8859(90)90074-y

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

110-6

issue

2

eissn

0198-8859

issn

1879-1166

pii

0198-8859(90)90074-Y

journal_volume

29

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Genetic diversity of HLA system in a population from Guerrero, Mexico.

    abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two E...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2019.05.015

    authors： Juárez-Nicolás F,Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Ortega-Yáñez A,Arrieta-Bolaños E,Clayton S,Bravo-Acevedo A,Arrazola-García MA,Immel A,Juárez-Barreto V,Benítez-Arvizu G,Vega-Martínez MDR,García-Álvarez R,

    更新日期：2020-09-01 00:00:00

  • Two sides of a coin: GG genotype of C7 provides protection against fibrosis severity while showing a higher risk for hepatocellular carcinoma in patients with hepatitis C.

    abstract：:The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to inve...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.06.009

    authors： de Lima RE,de Holanda Martins CM,do Carmo RF,Aroucha DCBL,Pereira LMMB,Vasconcelos LRS,Moura P

    更新日期：2018-09-01 00:00:00

  • Trans vivo analysis of human delayed-type hypersensitivity reactivity.

    abstract：:There are clinical situations in which it may be advantageous to monitor delayed type hypersensitivity (DTH) responses, an index of cell-mediated immunity, without exposing patients directly to the challenge antigens. For example, transplant patients may be at risk for becoming sensitized to donor antigens if injected...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00002-6

    authors： Carrodeguas L,Orosz CG,Waldman WJ,Sedmak DD,Adams PW,VanBuskirk AM

    更新日期：1999-08-01 00:00:00

  • Inverse association of peripheral blood CD4(+) invariant natural killer T cells with atopy in human asthma.

    abstract：:Invariant natural killer T (iNKT) cells have been reported to play a role in the pathogenesis of murine asthma. However, the role for iNKT cells in the pathogenesis of human asthma is not defined. In this study we aimed to determined how blood iNKT cells are associated with atopy in asthmatic individuals. Peripheral b...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.10.011

    authors： Koh YI,Shim JU,Wi JO,Han ER,Jin NC,Oh SH,Park CK,Park DJ

    更新日期：2010-02-01 00:00:00

  • HLA-G haplotype structure shows good conservation between different populations and good correlation with high, normal and low soluble HLA-G expression.

    abstract：:HLA-G molecule has considerable impact in various clinical fields, therefore many studies attempted to predict its expression based on HLA-G genotype. These studies have focused on polymorphisms in either the coding region or in one of the two untranslated regions (UTR) of the gene. The aim of our study was to determi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.10.027

    authors： Di Cristofaro J,El Moujally D,Agnel A,Mazières S,Cortey M,Basire A,Chiaroni J,Picard C

    更新日期：2013-02-01 00:00:00

  • Propagation of infiltrating lymphocytes and graft coronary disease in cardiac transplant recipients.

    abstract：:The pattern of lymphocyte growth from endomyocardial biopsies in 55 heart transplant recipients was shown to be correlated with the subsequent development of graft coronary disease. Persistent lymphocyte growth was observed in 39 patients, and 15 of these growers (or 41%) developed graft coronary disease. In contrast,...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90023-i

    authors： Kaufman CL,Zeevi A,Kormos RL,Zerbe TR,Keenan RJ,Uretsky BF,Griffith BP,Hardesty RL,Duquesnoy RJ

    更新日期：1990-06-01 00:00:00

  • Polymorphism in the upstream regulatory region of DQA1 genes and DRB1, QAP, DQA1, and DQB1 haplotypes in the German population.

    abstract：:Polymorphism in the URR of the MHC class II DQA1 gene defines ten different alleles named QAP. Oligotyping for the alleles of DRB1, QAP, DQA1, and DQB1 have been performed in 210 unrelated healthy controls from Germany. Moreover, 83 HTCs from the Tenth IHWS have been tested. Four point loci haplotypes (DRB1, QAP, DQA1...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)90098-1

    authors： Haas JP,Kimura A,Andreas A,Hochberger M,Keller E,Brünnler G,Bettinotti MP,Nevinny-Stickel C,Hildebrandt B,Sierp G

    更新日期：1994-01-01 00:00:00

  • T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients.

    abstract：:Based on CD25 expression, T follicular helper cells (Tfh) could be divided into T follicular regulatory (Tfr)-like subset (CD25+CD4+CXCR5+) and CD25- Tfh subset (CD25-CD4+CXCR5+). Patients with diffuse large B cell lymphoma (DLBCL) display high level of Tfr-like cells in blood and tumor. This Tfr-like subset could sup...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.05.008

    authors： Ma X,Zha J,He J,Chen L,Huang J,Wu W,Tian P,Qian BH,Yu L,Jiang Y,Xu B

    更新日期：2020-08-01 00:00:00

  • Stimulation of peripheral blood and intestinal mucosa cells by synthetic CpG oligodeoxynucleotides.

    abstract：:The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2003.12.013

    authors： Jugdé F,Boissier C,Birebent B,Vu N,D'halluin PN,Rioux-Leclercq N,Bretagne JF,Semana G,Heresebach D

    更新日期：2004-03-01 00:00:00

  • DR-restricted T-cell reactivities associated with the Dw19 specificity can be directed against the products of either locus DRB3 (DRw52c) or locus DRB1.

    abstract：:HLA-Dw 19 antigen presenting cells express two different DR beta chains encoded respectively by DRB1 and DRB3 genes. In the present study we determined which of these two DR beta chains is recognized by DR-restricted T-cell clones. First we selected influenza-specific, DR-restricted T-cell clones of which restriction ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90029-o

    authors： Zeliszewski D,Tiercy JM,Dorval I,Kaplan C,Mach B,Sterkers G

    更新日期：1990-08-01 00:00:00

  • Simultaneous HLA Class I and Class II antibodies screening with flow cytometry.

    abstract：:A flow cytometric method of simultaneously screening both HLA Class I and Class II panel reactive antibodies (PRA) was developed using a pool of 30 different Class I and 30 different Class II microbeads coated with purified HLA antigens. The antibodies in the serum that react specifically to the coated HLA antigens ar...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00020-2

    authors： Pei R,Wang G,Tarsitani C,Rojo S,Chen T,Takemura S,Liu A,Lee J

    更新日期：1998-05-01 00:00:00

  • Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined meta-analysis of association and family-based studies.

    abstract：:Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating t...

    journal_title：Human immunology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.humimm.2011.03.012

    authors： Cifuentes RA,Rojas-Villarraga A,Anaya JM

    更新日期：2011-07-01 00:00:00

  • Trends and challenges in searching for HLA-matched unrelated donors in Israel.

    abstract：:Despite the large local donor registries, for some Israeli patients an HLA-matched unrelated donor cannot be identified within a favorable time period. This study aims to retrospectively analyze donor search processes in our transplantation center in order to provide a basis to enhance the efficacy of these procedures...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.04.012

    authors： Israeli M,Yeshurun M,Stein J,Ram R,Shpilberg O,Levi CL,Klein T

    更新日期：2013-08-01 00:00:00

  • Monoclonal antibody definition of multiple polymorphic epitopes on human leukocyte antigen-DRw52.

    abstract：:Monoclonal antibodies have revealed complexity within the human leukocyte antigen class II antigens. We have studied epitopes present on a DR3 homozygous B-lymphoblastoid cell line using five polymorphic monoclonal antibodies produced and characterized in our laboratory. Serological analysis on a panel of B-cell lines...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90107-8

    authors： Fuggle SV,Carter C,Watts F,Kirkley J,Morris PJ

    更新日期：1987-11-01 00:00:00

  • The role of CD8 suppressors versus destructors in autoimmune central nervous system inflammation.

    abstract：:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) of putative autoimmune origin. Recent evidence indicates that MS autoimmunity is linked to defects in regulatory T-cell function, which normally regulates immune responses to self-antigens and prevents autoimmune disea...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.humimm.2008.07.014

    authors： Zozulya AL,Wiendl H

    更新日期：2008-11-01 00:00:00

  • DNA typing for class II HLA antigens with allele-specific or group-specific amplification. I. Typing for subsets of HLA-DR4.

    abstract：:DNA sequences that distinguish the subsets of HLA-DR4 are also found on several other alleles. This makes typing of heterozygotes with oligonucleotide probes quite impractical. We have therefore developed a procedure in which, in a first step, DNA of the genes to be analyzed is amplified selectively, using group-speci...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90094-6

    authors： Gao XJ,Fernandez-Vina M,Shumway W,Stastny P

    更新日期：1990-01-01 00:00:00

  • 14-Base pair polymorphism of human leukocyte antigen-G as genetic determinant in heart transplantation and cyclosporine therapy monitoring.

    abstract：:The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.07.012

    authors： Torres MI,Luque J,Lorite P,Isla-Tejera B,Palomeque T,Aumente MD,Arizon J,Peña J

    更新日期：2009-10-01 00:00:00

  • HLA-DQ beta 3.1 allele is a determinant of susceptibility to DR4-associated rheumatoid arthritis.

    abstract：:Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90033-5

    authors： Lanchbury JS,Sakkas LI,Marsh SG,Bodmer JG,Welsh KI,Panayi GS

    更新日期：1989-09-01 00:00:00

  • High-resolution allele frequencies for NGS based HLA-A, B, C, DQB1 and DRB1 typing of 23,595 bone marrow donors recruited for the Polish central potential unrelated bone marrow donor registry.

    abstract：:Next-generation sequencing (NGS)-based typings of HLA-A, B, C, DQB1 and DRB1 loci were performed from 2018 to 2019 in 23 595 newly recruited or re-typed adult potential bone marrow donors registered in Poltransplant Registry to characterize allele and haplotype frequencies of HLA system for loci important for hematopo...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2019.12.005

    authors： Nestorowicz K,Bogacz A,Bukowska A,Chraplak M,Czerwiński J,Góralski M,Gronkowski M,Jopek K,Kniżewski Ł,Kolasiński M,Kowalski ML,Nowak J,Sowiński M,Wróblewska-Kabba S,Tymoniuk B,Dudkiewicz M

    更新日期：2020-01-01 00:00:00

  • Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population.

    abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.03.017

    authors： Idris ZM,Miswan N,Muhi J,Mohd TA,Kun JF,Noordin R

    更新日期：2011-07-01 00:00:00

  • Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.

    abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2017.12.007

    authors： Grifoni A,Weiskopf D,Lindestam Arlehamn CS,Angelo M,Leary S,Sidney J,Frazier A,Phillips E,Mallal S,Mack SJ,Tippalagama R,Goonewardana S,Premawansa S,Premawansa G,Wijewickrama A,De Silva AD,Sette A

    更新日期：2018-02-01 00:00:00

  • A study of HLA-B∗15:02 in a Sri Lankan population: Implications for pharmacogenomic testing.

    abstract：:HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02,...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.04.001

    authors： Gunathilake KM,Wettasinghe KT,Dissanayake VH

    更新日期：2016-05-01 00:00:00

  • Gorilla major histocompatibility complex-DRB pseudogene orthologous to HLA-DRBVIII.

    abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(91)90058-h

    authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

    更新日期：1991-11-01 00:00:00

  • Elevation of HLA-G-expressing DC-10 cells in patients with gastric cancer.

    abstract：:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.01.003

    authors： Xu DP,Shi WW,Zhang TT,Lv HY,Li JB,Lin A,Yan WH

    更新日期：2016-09-01 00:00:00

  • TCRBV CDR3 diversity of CD4+ and CD8+ T-lymphocytes in HIV-infected individuals.

    abstract：:TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00361-5

    authors： Raaphorst FM,Schelonka RL,Rusnak J,Infante AJ,Teale JM

    更新日期：2002-01-01 00:00:00

  • HLA-G regulatory haplotypes and implantation outcome in couples who underwent assisted reproduction treatment.

    abstract：:The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.06.002

    authors： Costa CH,Gelmini GF,Wowk PF,Mattar SB,Vargas RG,Roxo VM,Schuffner A,Bicalho Mda G

    更新日期：2012-09-01 00:00:00

  • STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behçet's disease.

    abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.04.007

    authors： Hu K,Yang P,Jiang Z,Hou S,Du L,Li F

    更新日期：2010-07-01 00:00:00

  • HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group.

    abstract：:Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00200-7

    authors： Matte C,Lacaille J,Zijenah L,Ward B,Roger M

    更新日期：2000-11-01 00:00:00

  • Interaction of KIR genes and G1M immunoglobulin allotypes confer susceptibility to type 2 diabetes in Puerto Rican Americans.

    abstract：:The susceptibility to type 2 diabetes (T2D) involves genetic factors. We studied the distribution of KIR and MHC class I ligands phenotype and genotype frequencies, as well as immunoglobulin KM and GM allotype frequencies in a group of patients (N = 95) with T2D and ethnically matched healthy controls (N = 74) with Pu...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.08.297

    authors： Zuniga J,Romero V,Azocar J,Stern JN,Clavijo O,Almeciga I,Encinales L,Avendano A,Fridkis-Hareli M,Pandey JP,Yunis EJ

    更新日期：2006-11-01 00:00:00

  • CRP/CD11b ratio: a novel parameter for detecting gram-positive sepsis.

    abstract：:To commence proper antibiotic treatment in sepsis, timely knowledge of whether the cause of systemic infection is gram-negative (gram(-)) or gram-positive (gram(+)) bacteria in origin would be beneficial for clinicians. In this clinical prospective study, our objective was to develop a method for distinguishing betwee...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.01.009

    authors： Nuutila J,Jalava-Karvinen P,Hohenthal U,Laitinen I,Kotilainen P,Rajamäki A,Nikoskelainen J,Lilius EM

    更新日期：2009-04-01 00:00:00