Abstract:
:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In this study, the frequency and mean fluorescence intensity (MFI) of HLA-G+ DC-10 in the peripheral blood of 124 patients with gastric cancer (GC) and 130 normal controls was analyzed with flow cytometry. Plasma sHLA-G was analyzed with ELISA. Results showed both the percentages of peripheral HLA-G+ DC-10 (median: 0.13% vs 0.01%; p<0.01) and MFI of HLA-G on these cells (median: 310.0 vs 91.5; p<0.01) were dramatically increased in GC patients than in normal controls. The frequency of HLA-G+ DC-10 in GC patients was strongly relative to the tumor grade (p=0.021). sHLA-G levels in GC patients were significantly higher than in healthy controls (median: 85.80U/ml vs 61.20U/ml; p<0.01). There was no significant correlation between the percentage of DC-10 and plasma sHLA-G (p>0.05). However, the increased HLA-G+ DC-10, HLA-G MFI and plasma sHLA-G in patients with gastric cancer could be a diagnostic factor with the area under the ROC curve with 0.947 (p<0.01), 0.882 (p<0.01) and 0.700 (p<0.01) respectively. Given the immune tolerant function of DC-10 could play, the increased DC-10 might play an important role in immune suppression for patients with gastric cancer, while more studies are necessary to illustrate the clinical relevance of DC-10 in cancer patients.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Xu DP,Shi WW,Zhang TT,Lv HY,Li JB,Lin A,Yan WHdoi
10.1016/j.humimm.2016.01.003subject
Has Abstractpub_date
2016-09-01 00:00:00pages
800-4issue
9eissn
0198-8859issn
1879-1166pii
S0198-8859(16)00004-5journal_volume
77pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.10.001
更新日期:2010-01-01 00:00:00
abstract::Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.05.011
更新日期:2011-10-01 00:00:00
abstract::Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remain...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.08.009
更新日期:2018-12-01 00:00:00
abstract::Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. A...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.05.002
更新日期:2011-09-01 00:00:00
abstract::The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rej...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(98)00059-7
更新日期:1998-09-01 00:00:00
abstract::Apoptosis is a critical process in tissue homeostasis and results in immediate removal of the dying cell by professional phagocytes such as macrophages and dendritic cells. Phagocytosis of apoptotic cells actively suppresses production of proinflammatory growth factors and cytokines. Impaired phagocytosis of apoptotic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.12.008
更新日期:2007-03-01 00:00:00
abstract::Even when kidney allografts are well matched for human leukocyte antigen (HLA) and anti-HLA antibodies are not detected, graft rejection can still occur. There is evidence that some patients who lose their graft have antibodies specific for major histocompatibility complex (MHC) class I-related chain A (MICA) antigens...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.05.004
更新日期:2011-10-01 00:00:00
abstract::The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative disorders is rarely expressed at cell surface. In this article, we will demonstrate that the plasmatic level of soluble HLA-G was significant...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2003.08.345
更新日期:2003-11-01 00:00:00
abstract::Neem leaf preparation (NLP) was found to activate natural killer (NK) cells (CD56(+)CD3(-)) to enhance their cytotoxic ability to tumor cells and stimulate the release of interleukin-12 (IL-12) from macrophages from healthy individuals and head-and-neck squamous cell carcinoma patients. NLP upregulated cytotoxic (CD16...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.08.002
更新日期:2007-10-01 00:00:00
abstract::An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00008-6
更新日期:1997-04-15 00:00:00
abstract::HLA-Dw 19 antigen presenting cells express two different DR beta chains encoded respectively by DRB1 and DRB3 genes. In the present study we determined which of these two DR beta chains is recognized by DR-restricted T-cell clones. First we selected influenza-specific, DR-restricted T-cell clones of which restriction ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90029-o
更新日期:1990-08-01 00:00:00
abstract::Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2008.12.005
更新日期:2009-02-01 00:00:00
abstract::Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymp...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.01.011
更新日期:2013-05-01 00:00:00
abstract::The polymorphic MICA gene encodes glycoproteins that activate T cells and NK cells through the NKG2D receptor and may costimulate immune functions. We found that MICA was expressed on freshly isolated human fibroblasts and was markedly decreased when fibroblasts were grown to confluency in culture dishes. MICA surface...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.018
更新日期:2006-03-01 00:00:00
abstract::The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.03.010
更新日期:2015-05-01 00:00:00
abstract::We have investigated the distribution of genotypes of a restriction fragment length polymorphism of the T-cell receptor beta-subunit gene in Caucasoid controls and patients with insulin-dependent diabetes mellitus, celiac disease, dermatitis herpetiformis, and idiopathic membranous nephropathy and also in South Indian...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90086-5
更新日期:1990-04-01 00:00:00
abstract::The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00041-7
更新日期:2003-05-01 00:00:00
abstract::T lymphocyte clones (TLCs) specific for Chlamydia trachomatis were obtained after limiting dilution of activated T cells from a single donor, BS (HLA-A3; B7,15; DR1, 4; DRw53; DPw4). Most of the proliferative TLCs obtained apparently used restriction elements on DR1 or DR4 molecules, expressed in the antigen-presentin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90060-0
更新日期:1984-12-01 00:00:00
abstract::Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculo...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.04.004
更新日期:2011-09-01 00:00:00
abstract::Uninfected, as well as feline leukemia virus (FeLV) infected human cells cultured under high cell density conditions undergo changes in the expression of major histocompatibility complex (MHC) antigens, as determined by indirect trace binding radio immunoassay (RIA) using monoclonal anti-HLA antibodies and by decrease...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(83)80006-8
更新日期:1983-06-01 00:00:00
abstract::The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-ant...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2019.04.008
更新日期:2019-08-01 00:00:00
abstract::The monoclonal antibodies (MoAbs) KS3 and KS4 are secreted by hybridomas constructed with splenocytes from a BALB/c mouse sequentially immunized with the cultured lymphoid cells JKu and LG-2 which share only the HLA-B27 specificity. Serologic and immunochemical assays have shown that the two MoAbs recognize the same (...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(88)90071-7
更新日期:1988-03-01 00:00:00
abstract::Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.03.010
更新日期:2017-01-01 00:00:00
abstract::Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2014.06.009
更新日期:2014-08-01 00:00:00
abstract::Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.06.001
更新日期:2019-10-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::Genes encoding for prolactin (PRL) and its receptor (PRLR) are possible candidates for multiple sclerosis (MS) and systemic lupus erythematosus (SLE) susceptibility. In fact: (1) a prolactin secretion dysfunction has been described in several autoimmune diseases including SLE and MS and their animal models; (2) both P...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00804-2
更新日期:2003-02-01 00:00:00
abstract::We compared the T cell receptor (TCR) V beta gene family repertoire in peripheral blood mononuclear cells (PBMC) and lymph node (LN) cells from 7 human immunodeficiency virus (HIV)-infected patients and 3 seronegative healthy controls. Virtually all the V beta family specificities were represented in patient PBMC and ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00205-x
更新日期:1997-10-01 00:00:00
abstract::RING 11, a second transport-associated gene (TAP2), has been recently identified in the DR-DP interval of the human class II region. Two predominant alleles, TAP2A and TAP2B, differing by 17 amino acids at the C-terminus of the ATP-binding domain are present in the Caucasoid population at frequencies of 79% and 21%, r...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90544-b
更新日期:1993-11-01 00:00:00
abstract::In the present study, we explored the specific requirements for lysis of human activated T cells by CD4+ CTLs. This was achieved by using human CD4+ T cell lines or clones specific for a peptidic fragment of influenza virus as both CTL effectors and target T cells (TTCs). Our results further establish that human activ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90094-4
更新日期:1992-09-01 00:00:00