Abstract：
:The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rejection, T cell response spreads to formerly poorly presented cryptic allogeneic MHC peptides. This phenomenon is likely to play an important role in the amplification and the perpetuation of the rejection process. Additionally, we present evidence that T cell repertoire selection to allogeneic MHC peptides is acquired via recognition of self-MHC peptides presented in the thymus during ontogeny. Supporting this view, we have shown that indirect alloresponses can lead to self-T cell tolerance breakdown to cross-reactive determinants on self-MHC molecules or alternatively that sensitization of recipients to self-MHC peptides can lead to accelerated graft rejection. It is therefore essential to determine the factors which govern the processing and presentation of self and allogeneic MHC molecules and to elucidate the mechanisms regulating subsequent T cell responses in order to design antigen-specific based immune therapies in transplantation.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Benichou G,Malloy KM,Tam RC,Heeger PS,Fedoseyeva EVdoi
10.1016/s0198-8859(98)00059-7subject
Has Abstractpub_date
1998-09-01 00:00:00pages
540-8issue
9eissn
0198-8859issn
1879-1166pii
S0198-8859(98)00059-7journal_volume
59pub_type
杂志文章,评审相关文献
HUMAN IMMUNOLOGY文献大全abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.03.005
更新日期：2008-06-01 00:00:00
abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.09.003
更新日期：2007-11-01 00:00:00
abstract：:A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(97)00143-2
更新日期：1997-08-01 00:00:00
abstract：:A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2004.02.012
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.02.006
更新日期：2018-04-01 00:00:00
abstract：:Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.03.018
更新日期：2006-01-01 00:00:00
abstract：:It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nuc...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.10.015
更新日期：2017-02-01 00:00:00
abstract：:A novel cell surface molecule, DN4, defined by an mAb raised against human thymic epithelial cells, showed a specificity for epithelial cells of the thymic cortex. This antigen was not expressed at detectable levels on any other types of tissues in the human body except for the thymus and bone marrow. Immunohistochemi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(95)00168-9
更新日期：1996-02-01 00:00:00
abstract：:FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding thei...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2009.02.007
更新日期：2009-05-01 00:00:00
abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.11.014
更新日期：2010-02-01 00:00:00
abstract：:The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(83)90065-4
更新日期：1983-02-01 00:00:00
abstract：:We followed 138 Spanish patients (37 men and 101 women) with rheumatoid arthritis (RA) to analyze whether patient sex influenced the HLA-DRB1 associations with disease susceptibility. Results showed that, although a high increase of the shared epitope (SE) was observed in both genders, distribution of HLA-DRB1 specifi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00119-6
更新日期：1999-12-01 00:00:00
abstract：:We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.06.025
更新日期：2013-10-01 00:00:00
abstract：:Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2016.05.021
更新日期：2016-11-01 00:00:00
abstract：:Neem leaf preparation (NLP) was found to activate natural killer (NK) cells (CD56(+)CD3(-)) to enhance their cytotoxic ability to tumor cells and stimulate the release of interleukin-12 (IL-12) from macrophages from healthy individuals and head-and-neck squamous cell carcinoma patients. NLP upregulated cytotoxic (CD16...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.08.002
更新日期：2007-10-01 00:00:00
abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2014.04.002
更新日期：2014-06-01 00:00:00
abstract：:When lymphocytes of healthy donors were incubated with penicillin and washed before HLA typing, the cytotoxic reactivity of some typing sera with their corresponding antigen was blocked. When the penicillin was added to the cytotoxicity assay at different times, competition between penicillin and alloantiserum for bin...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(82)90033-7
更新日期：1982-08-01 00:00:00
abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2020.07.005
更新日期：2020-12-01 00:00:00
abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(90)90104-w
更新日期：1990-02-01 00:00:00
abstract：:Beta 2m serum levels have been shown to be increased in patients with tuberculosis and HIV infection. We determined the stability of beta 2m and of sHLA-I dimers in serum, and then determined the levels of both molecules in 60 non-HIV-infected patients with active pulmonary tuberculosis and in 55 adult controls. The l...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)90066-3
更新日期：1994-07-01 00:00:00
abstract：:The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. How...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.07.008
更新日期：2010-10-01 00:00:00
abstract：:Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 w...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2008.01.020
更新日期：2008-04-01 00:00:00
abstract：:We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2005.07.001
更新日期：2005-09-01 00:00:00
abstract：:The breakdown of tolerance to autologous bacterial flora has been implicated as a major factor contributing to the initiation and perpetuation of chronic inflammation in inflammatory bowel diseases (IBD). To test whether bacterial DNA is at the origin of inflammation in IBD, we have examined the response of lamina pro...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2003.12.013
更新日期：2004-03-01 00:00:00
abstract：:Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.05.005
更新日期：2006-09-01 00:00:00
abstract：:Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(91)90106-j
更新日期：1991-10-01 00:00:00
abstract：:To clarify the molecular relationship between HLA loci and ulcerative colitis (UC) in Japanese patients, we performed HLA-DP genotyping by the PCR-RFLP method and studied tumor necrosis factor beta-chain genetic polymorphism by Southern hybridization, in addition to conventional serologic typing. Significant increase ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90113-f
更新日期：1993-02-01 00:00:00
abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.01.004
更新日期：2018-03-01 00:00:00
abstract：:Dendritic cells (DCs) exposed to tumor antigens followed by treatment with T(h)1-polarizing differentiation signals have paved the way for the development of DC-based cancer vaccines. Critical parameters for assessment of the optimal functional state of DCs and prediction of the vaccine potency of activated DCs have i...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2009.10.001
更新日期：2010-01-01 00:00:00
abstract：:Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/s0198-8859(99)00151-2
更新日期：2000-02-01 00:00:00
