Abstract:
:Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of typically either short or long length. A genetic link is known between these MUC1 polymorphisms and inflammation-driven diseases, although the mechanism is not fully understood. We previously showed that MUC1 on murine macrophages specifically restricts activation of the NLRP3 inflammasome, thereby repressing inflammation. This study evaluated the effect of MUC1 VNTR polymorphisms on activity of the NLRP3 inflammasome in human macrophages, finding that long MUC1 alleles correlated with increased IL-1β production following NLRP3 inflammasome activation. This indicates that the length of MUC1 can influence IL-1β production, thus providing the first evidence of an immune-modulatory role of MUC1 VNTR polymorphisms in human macrophages.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Dhar P,Sarkar S,Ng GZ,Kalitsis P,Saeed MA,McGuckin MA,Ellis JA,Sutton Pdoi
10.1016/j.humimm.2019.06.001subject
Has Abstractpub_date
2019-10-01 00:00:00pages
878-882issue
10eissn
0198-8859issn
1879-1166pii
S0198-8859(19)30115-6journal_volume
80pub_type
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