当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells.

NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells.

Abstract：

:The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies demonstrated the role of NF-κB and AP-1 transcription factors in addition to let-7 microRNA in CCR7 expression. Our ChIP assays further show the binding of Sp-1, Sp-3 and NFAT-1 transcription factors to their potential binding sites in the 1Kb promoter region with the later found to inhibit whilst Sp-1, and Sp-3 were found to stimulate CCR7 expression as demonstrated by transfection assays. On the other hand, in addition to the known let-7 regulation of CCR7, we found miR-21 to have a highly conserved target region in CCR7 3'UTR and to be significantly down-regulated during the course of dendritic cell maturation, allowing for high expression of CCR7.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Al Akoum C,Akl I,Rouas R,Fayyad-Kazan M,Falha L,Renno T,Burny A,Lewalle P,Fayyad-Kazan H,Badran B

doi

10.1016/j.humimm.2015.03.010

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

307-17

issue

5

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(15)00102-0

journal_volume

76

pub_type

杂志文章

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