Soluble HLA proteins with bound peptides are released from the cell surface by the membrane metalloproteinase.

abstract：:To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlant...

journal_title：Human immunology

authors： Oumhani K,Canossi A,Piancatelli D,Di Rocco M,Del Beato T,Liberatore G,Aureli A,Benjoaud A,El Aouad R,Adorno D,Casciani CU

更新日期：2002-02-01 00:00:00

abstract：:In an attempt to develop a suitable model for increasing the yield of human anti-HLA mAbs, we have used mice with SCID for i.p. injection of two human-mouse heterohybridomas. HMP1 hybridoma secretes a DQB1*0201 allele-specific human mAb whereas HMP12 secretes a human mAb recognizing the DRB1*1101, 1102, 1103, and 1104...

journal_title：Human immunology

authors： Pistillo MP,Sguerso V,Ferrara GB

更新日期：1992-12-01 00:00:00

abstract：:In order to study the HLA class II restriction repertoire in antigen presentation to T cells, T lymphoblasts (T-LB) of ten different HLA class II donors were generated by a simple and rapid technique; peripheral blood lymphocytes (PBL) were restimulated in vitro with purified protein derivative (PPD) or tetanus toxoid...

journal_title：Human immunology

authors： Ottenhoff TH,Elferink DG,Hermans J,de Vries RR

更新日期：1985-06-01 00:00:00

abstract：:It has been known for 40 years that cytotoxic human leukocyte antigen (HLA) antibodies are associated with graft rejection. However, the complement-dependent cytotoxicity assay (CDC) used to define these clinically deleterious antibodies suffers from a lack of sensitivity and specificity. Recently, methods exploiting ...

journal_title：Human immunology

authors： Chen G,Sequeira F,Tyan DB

更新日期：2011-10-01 00:00:00

abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...

journal_title：Human immunology

authors： Kitaya K,Yasuo T

更新日期：2010-02-01 00:00:00

abstract：:Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...

journal_title：Human immunology

authors： Hetrick SJ,Schillinger KP,Zachary AA,Jackson AM

更新日期：2011-04-01 00:00:00

abstract：:One of the major categories of disease-causing micro-organisms are viruses. New studies on many different viruses have shown that virus attachment and cell entry is often a multistep process, requiring many interactions between the virus and cell surface molecules. In this study, we have attempted to identify the cell...

journal_title：Human immunology

authors： Triantafilou M,Triantafilou K,Wilson KM

更新日期：2000-09-01 00:00:00

abstract：:We have investigated the distribution of genotypes of a restriction fragment length polymorphism of the T-cell receptor beta-subunit gene in Caucasoid controls and patients with insulin-dependent diabetes mellitus, celiac disease, dermatitis herpetiformis, and idiopathic membranous nephropathy and also in South Indian...

journal_title：Human immunology

authors： Niven MJ,Caffrey C,Moore RH,Sachs JA,Mohan V,Festenstein H,Hoover ML,Hitman GA

更新日期：1990-04-01 00:00:00

abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

journal_title：Human immunology

authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

更新日期：1997-09-15 00:00:00

abstract：:Recurrent Spontaneous Abortion (RSA) is postulated to be due to several factors including immunogenetic mechanisms. Many studies have been conducted on the effect of the MHC region in the reproductive phenomena suggesting an immunological or genetic involvement in RSA. We studied couples with 3 or more abortions among...

journal_title：Human immunology

authors： Pennesi G,Brioli G,Lulli P,Mariani B,Morellini M,Nicotra M,Trabace S

更新日期：1998-06-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB ...

journal_title：Human immunology

authors： Spurrell DR,Oldford SA,Frost T,Larsen B,Codner D,Edgecombe A,Drover S

更新日期：2004-12-01 00:00:00

abstract：:PCR-based analyses were performed for the identification of HLA-B44 subgroups. Genomic DNA from six homozygous cell lines and 44 healthy individuals who had serologically tested positive for HLA-B44 was investigated for polymorphism in exons 2 and 3 of the HLA-B44 genes. Two primers were designed for specific amplific...

journal_title：Human immunology

authors： Yao Z,Keller E,Scholz S,McNicholas A,Volgger A,Albert ED

更新日期：1995-01-01 00:00:00

abstract：:With a larger, independent cohort and more sophisticated measures, we sought to confirm our work that indicated independence of humoral and cellular immunity following measles vaccination. We recruited an age-stratified random cohort of 764 healthy subjects from all socioeconomic strata, all with medical-record docume...

journal_title：Human immunology

authors： Jacobson RM,Ovsyannikova IG,Vierkant RA,Pankratz VS,Poland GA

更新日期：2012-05-01 00:00:00

abstract：:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...

journal_title：Human immunology

authors： Xu DP,Shi WW,Zhang TT,Lv HY,Li JB,Lin A,Yan WH

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. METHODS:407...

journal_title：Human immunology

authors： Wu Z,Zheng W,Xu J,Sun F,Chen H,Li P,Chen S,Shen M,Zhang W,You X,Wu Q,Zhang F,Li Y

更新日期：2014-03-01 00:00:00

abstract：:MHC class II molecules play a central role in the control of the immune response, but their biologic function and mechanism of action on the surface of activated human T lymphocytes are not entirely understood. In our study, the functional role of HLA class II molecules in T-blast proliferation was investigated by ana...

journal_title：Human immunology

authors： Di Rosa F,D'Oro U,Ruggiero G,Racioppi L,Acquaviva A,Ferrone S,Fontana S,Zappacosta S

更新日期：1993-12-01 00:00:00

abstract：:Alloantibodies are known to influence transplant outcomes. Apart from human leukocyte antigens (HLA), non-HLA targets have been suggested to play a significant role, but little is known about their nature. Here, we present a novel method for identification and characterization of cell surface antigens bound by allorea...

journal_title：Human immunology

authors： Heinold A,Kuehl B,Brenner-Weiss G,Opelz G,Tran TH

更新日期：2010-05-01 00:00:00

abstract：:Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this ...

journal_title：Human immunology

authors： Wang YJ,Zhang NJ,Chen E,Chen CJ,Bu YH,Yu P

更新日期：2016-05-01 00:00:00

abstract：:4-Hydroxynonenal (HNE) is the most abundant and toxic aldehyde generated by the oxidation of plasma membrane polyunsaturated fatty acids. Systemic lupus erythematosus (SLE), a chronic autoimmune disease, is primarily characterized by increased levels of autoantibodies, predominantly against ds-DNA. However, the initia...

journal_title：Human immunology

authors： Khatoon F,Moinuddin,Alam K,Ali A

更新日期：2012-11-01 00:00:00

abstract：:Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...

journal_title：Human immunology

authors： Tanahashi M,Yokoyama T,Kobayashi Y,Yamakawa Y,Maeda M,Fujii Y

更新日期：2001-08-01 00:00:00

abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...

journal_title：Human immunology

authors： Dave VP,Larché M,Rencher SD,Koop BF,Hurwitz JL

更新日期：1993-07-01 00:00:00

abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...

journal_title：Human immunology

authors： Gambelunghe G,Brozzetti AL,Ghaderi M,Tortoioli C,Falorni A

更新日期：2006-12-01 00:00:00

abstract：:Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...

journal_title：Human immunology

authors： Matte C,Lacaille J,Zijenah L,Ward B,Roger M

更新日期：2000-11-01 00:00:00

abstract：:Highly sensitized renal transplant candidates present a group at high risk for acute and chronic rejection. The probability of finding compatible donors for these recipients is significantly lower in comparison to those who have low PRA values. As a consequence, these patients spend longer time on the waiting list and...

journal_title：Human immunology

authors： Lobashevsky AL,Senkbeil RW,Shoaf JL,Stephenson AK,Skelton SB,Burke RM,Deierhoi MH,Thomas JM

更新日期：2002-05-01 00:00:00

abstract：:TCRBV CDR3 repertoire diversity was analyzed in a cross-sectional study of HIV-infected individuals by CDR3 fingerprinting/spectratyping and single strand conformation polymorphism (SSCP). Most TCRBV families were detected in CD4+ cells of HIV-infected patients with CD4 counts ranging from 35 to 1103. In patients with...

journal_title：Human immunology

authors： Raaphorst FM,Schelonka RL,Rusnak J,Infante AJ,Teale JM

更新日期：2002-01-01 00:00:00

abstract：:The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...

journal_title：Human immunology

authors： Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

更新日期：1989-11-01 00:00:00

abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...

journal_title：Human immunology

authors： Carrier CM,Mollen N,Rothman WC,Rodriguez de Cordoba S,Rey-Campos J,Ginsberg-Fellner F,Carpenter C,Rubinstein P

更新日期：1989-01-01 00:00:00

abstract：:We compared the T cell receptor (TCR) V beta gene family repertoire in peripheral blood mononuclear cells (PBMC) and lymph node (LN) cells from 7 human immunodeficiency virus (HIV)-infected patients and 3 seronegative healthy controls. Virtually all the V beta family specificities were represented in patient PBMC and ...

journal_title：Human immunology

authors： Mion M,Indraccolo S,Feroli F,Minuzzo S,Masiero S,Zamarchi R,Barelli A,Borri A,Chieco-Bianchi L,Amadori A

更新日期：1997-10-01 00:00:00

abstract：:The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant ...

journal_title：Human immunology

authors： Malheiro J,Tafulo S,Dias L,Martins S,Fonseca I,Beirão I,Castro-Henriques A,Cabrita A

更新日期：2017-09-01 00:00:00

abstract：:Platelet alloimmunization may result in post-transfusion purpura, and during pregnancy may cause neonatal alloimmune thrombocytopenia (NAIT), with a frequency estimated at 1.3 per 1000 live births. The risk of morbidity is significant: 20% of affected infants have neurologic sequelae and the death rate is about 10%. A...

journal_title：Human immunology

authors： Semana G,Zazoun T,Alizadeh M,Morel-Kopp MC,Genetet B,Kaplan C

更新日期：1996-04-01 00:00:00