当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > CD8+ suppressor T cells resurrected.

CD8+ suppressor T cells resurrected.

Abstract：

:This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were CD8(+), to the view that such cells did not exist, to the identification of the transcription factor Foxp3 as a key orchestrator of inhibitory function. Although most Foxp3(+) cells in a resting animal are CD4(+)CD25(+) cells, Foxp3 expression and inhibitory function can be induced by antigens in the periphery by selective cytokine conditions, particularly TGF-beta. Such induced T cells occur within both the CD4 and the CD8 T-cell lineages and appear to mediate suppression by inhibiting the costimulatory activity of antigen-presenting cells and the production of inhibitory cytokines. Recent data generated by analysis of TCR Tg T cells that do not select many Foxp3-positive cells during thymic development are reviewed, emphasizing the pattern of "linked suppression" and focus of the relative potency of different mechanisms of suppression.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Kapp JA,Bucy RP

doi

10.1016/j.humimm.2008.07.018

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

715-20

issue

11

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(08)00150-X

journal_volume

69

pub_type

杂志文章,评审

相关文献

HUMAN IMMUNOLOGY文献大全
  • Decreased risk for myocardial infarction and lower tumor necrosis factor-alpha levels in carriers of variants of the PDCD1 gene.

    abstract：:Increasing interest has been directed toward the inflammatory mechanisms involved in the pathogenesis of myocardial infarction (MI). In the search for genetic mechanisms underlying these inflammatory components, we studied variants of programmed cell death-1 (PDCD1), an immunoinhibitory receptor that inhibits lymphocy...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.05.005

    authors： Bennet AM,Alarcón-Riquelme M,Wiman B,de Faire U,Prokunina-Olsson L

    更新日期：2006-09-01 00:00:00

  • The influence of the hinge region length in binding of human IgG to human Fcgamma receptors.

    abstract：:Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00075-5

    authors： Redpath S,Michaelsen TE,Sandlie I,Clark MR

    更新日期：1998-11-01 00:00:00

  • The diversity of antigen-specific TCR repertoires reflects the relative complexity of epitopes recognized.

    abstract：:Antigen-selected T cell receptor (TCR) repertoires vary in complexity from very limited to extremely diverse. We have previously characterized two different CD8 T cell responses, which are restricted by the same mouse major histocompatibility complex (MHC) class I molecule, H-2 Kd. The TCR repertoire in the response a...

    journal_title：Human immunology

    pub_type： 杂志文章,评审

    doi：10.1016/s0198-8859(97)00082-7

    authors： Maryanski JL,Casanova JL,Falk K,Gournier H,Jaulin C,Kourilsky P,Lemonnier FA,Lüthy R,Rammensee HG,Rötzschke O,Servis C,López JA

    更新日期：1997-05-01 00:00:00

  • CD28 gene polymorphisms and acute cellular rejection after liver transplantation.

    abstract：:The co-stimulatory molecule CD28 plays an important role in T-cell-mediated immune response like acute cellular liver transplant rejection. The aim of the retrospective case- control study was to examine whether the single nucleotide polymorphisms (SNPs) rs3116487, rs3116494, and rs3116496 of the CD28 gene are associa...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.10.002

    authors： Thude H,Tiede P,Sterneck M,Peine S,Nashan B,Koch M

    更新日期：2020-12-01 00:00:00

  • North African genes in Iberia studied by Y-chromosome DNA haplotype V.

    abstract：:Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00287-7

    authors： Lucotte G,Gérard N,Mercier G

    更新日期：2001-09-01 00:00:00

  • The role of human leukocyte antigen DRB1-DQB1 haplotypes in the susceptibility to acquired idiopathic thrombotic thrombocytopenic purpura.

    abstract：:The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.11.005

    authors： Sinkovits G,Szilágyi Á,Farkas P,Inotai D,Szilvási A,Tordai A,Rázsó K,Réti M,Prohászka Z

    更新日期：2017-02-01 00:00:00

  • Production of a chimeric allergen derived from the major allergen group 1 of house dust mite species in Nicotiana benthamiana.

    abstract：:Plants are widely accepted as a general platform for the large-scale production of recombinant proteins, which has been demonstrated by the successful expression of various exogenous proteins. Using plants as a bioreactor for mass production of target proteins for vaccines is thought to show the most potential. This s...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.01.002

    authors： Li C,Jiang Y,Guo W,Liu Z

    更新日期：2013-05-01 00:00:00

  • DN4: a novel cell surface molecule on cortical epithelial cells of the human thymus.

    abstract：:A novel cell surface molecule, DN4, defined by an mAb raised against human thymic epithelial cells, showed a specificity for epithelial cells of the thymic cortex. This antigen was not expressed at detectable levels on any other types of tissues in the human body except for the thymus and bone marrow. Immunohistochemi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(95)00168-9

    authors： Chung DH,Choi EY,Lee GK,Bae YM,Hahn JH,Kim SS,Song HG,Park WS,Ahn HS,Park SH

    更新日期：1996-02-01 00:00:00

  • Isoforms of human leukocyte antigen-G and their inhibitory receptors in human kidney allograft acceptance.

    abstract：:Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the ma...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.07.023

    authors： Wu J,Zhang W,Hernandez-Lopez P,Fabelo E,Parikh M,Mulloy LL,Horuzsko A

    更新日期：2009-12-01 00:00:00

  • Elevated serum BAFF levels in patients with autoimmune hepatitis.

    abstract：:Serum cytokines are thought to be involved in autoimmune hepatitis (AIH) pathogenesis via immune dysregulation. B-cell activating factor belonging to the tumor necrosis factor family (BAFF) is a member of the tumor necrosis factor (TNF) superfamily and is known for its role in the survival and maturation of B cells. T...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.03.010

    authors： Migita K,Abiru S,Maeda Y,Nakamura M,Komori A,Ito M,Fujiwara S,Yano K,Yatsuhashi H,Eguchi K,Ishibashi H

    更新日期：2007-07-01 00:00:00

  • Coexistence of an MHC chromosomal segment marked by HLA B17,BfS,C4A6,B1,DR7, and DQw9 in different ethnic groups.

    abstract：:Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(88)90015-8

    authors： Kay PH,Dawkins RL,Williamson J,Tokunaga K,Christiansen FT,Charoenwong P

    更新日期：1988-09-01 00:00:00

  • Monoclonal antibodies specific for human polymorphic cell surface antigens. I. Evaluation of methodologies. Report on a workshop.

    abstract：:Five techniques, the direct and the antiglobulin enhanced cytotoxicity assays, indirect immunofluorescence, the enzyme-linked immunosorbent assay, and the radioimmunoassay, were evaluated in a workshop to determine their utility in studies of the interactions of monoclonal antibodies with HLA antigens expressed on lym...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(82)90016-7

    authors： Krakauer H,Hartzman RJ,Johnson AH

    更新日期：1982-04-01 00:00:00

  • Mannose-binding lectin level and deficiency is not associated with inflammatory bowel diseases, disease phenotype, serology profile, and NOD2/CARD15 genotype in a large Hungarian cohort.

    abstract：:Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.01.012

    authors： Papp M,Lakatos PL,Harsfalvi J,Farkas G,Palatka K,Udvardy M,Molnar T,Farkas K,Nagy F,Veres G,Lakatos L,Kovacs A,Dinya T,Kocsis AK,Papp J,Hungarian IBD Study Group.,Altorjay I

    更新日期：2010-04-01 00:00:00

  • Analysis of the cord blood T lymphocyte response to superantigen.

    abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00107-4

    authors： Macardle PJ,Wheatland L,Zola H

    更新日期：1999-02-01 00:00:00

  • Major histocompatibility complex class I-related chain A allele mismatching, antibodies, and rejection in renal transplantation.

    abstract：:Even when kidney allografts are well matched for human leukocyte antigen (HLA) and anti-HLA antibodies are not detected, graft rejection can still occur. There is evidence that some patients who lose their graft have antibodies specific for major histocompatibility complex (MHC) class I-related chain A (MICA) antigens...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.05.004

    authors： Cox ST,Stephens HA,Fernando R,Karasu A,Harber M,Howie AJ,Powis S,Zou Y,Stastny P,Madrigal JA,Little AM

    更新日期：2011-10-01 00:00:00

  • Attenuated expression of interferon-β and interferon-λ1 by human alternatively activated macrophages.

    abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.267

    authors： El Fiky A,Perreault R,McGinnis GJ,Rabin RL

    更新日期：2013-12-01 00:00:00

  • Bone marrow transplantation in Brazil.

    abstract：:The first program of bone marrow transplantation in Latin America was started 5 years ago at the Federal University Hospital, Curitiba, Paraná. The results of 62 patients who underwent bone marrow transplantation are presented and discussed. ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(85)90240-x

    authors： Ferreira E,Dulley FL,Morsoletto F,Neto JZ,Pasquini R

    更新日期：1985-11-01 00:00:00

  • IL-4 polymorphisms, HRCT score and lung tissue markers in idiopathic pulmonary fibrosis.

    abstract：AIMS:We studied the influence of IL-4 gene polymorphisms on the IPF phenotype, i.e., extent of radiological changes (HRCT interstitial (IS) and alveolar (AS) score) and histopathological markers from lung biopsies. PATIENTS AND METHODS:46 IPF patients underwent genotyping, 43 of them had HRCT and 14 patients had a sur...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.07.011

    authors： Vasakova M,Sterclova M,Matej R,Olejar T,Kolesar L,Skibova J,Striz I

    更新日期：2013-10-01 00:00:00

  • Effect of granulocyte-macrophage colony stimulating factor on endothelial antigenicity.

    abstract：:We have investigated if recombinant granulocyte-macrophage colony stimulating factor (GM-CSF), alone or in concert with recombinant gamma interferon, affects the endothelial cell expression of class I major histocompatibility complex antigen. Results obtained show that the GM-CSF increases class I expression on the en...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90016-i

    authors： Leszczynski D,Häyry P

    更新日期：1990-06-01 00:00:00

  • Soluble HLA-DR levels in serum are associated with therapy and genetic factors in rheumatoid arthritis.

    abstract：:As rheumatoid arthritis (RA) is an HLA-DR associated autoimmune disease and soluble HLA-DR (sHLA-DR) molecules have the capacity to regulate the immune response, we studied the sHLA-DR levels in RA patients in view of therapy modalities and clinical and biologic parameters of disease activity. For this sHLA-DR concent...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00431-7

    authors： Verbruggen LA,Versaen H,Rebmann V,Duquet W,De Cock S,Grosse-Wilde H,Demanet C

    更新日期：2002-09-01 00:00:00

  • Natural killer cell crossmatch: functional analysis of inhibitory killer immunoglobulin-like receptors and their HLA ligands.

    abstract：:Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.02.001

    authors： Han M,Fallena M,Guo Y,Stastny P

    更新日期：2007-06-01 00:00:00

  • Alloantibodies in heart transplantation.

    abstract：:The presence of complement fixing anti-human leukocyte antigen (HLA) antibodies in the circulation of organ transplant recipients may result in heart allograft rejection. Here, we assessed the clinical impact of pre- and post-transplantation allosensitization on long-term survival of heart allografts. Sequential sampl...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.06.015

    authors： Ho EK,Vlad G,Colovai AI,Vasilescu ER,Schwartz J,Sondermeijer H,Burke E,Marboe CC,Itescu S,Suciu-Foca N,Mancini D

    更新日期：2009-10-01 00:00:00

  • Emerging role of donor-specific anti-human leukocyte antigen antibody determination for clinical management after solid organ transplantation.

    abstract：:Preformed and de novo donor-specific HLA antibodies (DSA) have been associated with allograft dysfunction and failure. The application of solid-phase methods have increased the sensitivity and specificity of antibody detection; however the clinical significance of these DSA is under evaluation. In the present study, w...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.06.009

    authors： Zeevi A,Lunz JG 3rd,Shapiro R,Randhawa P,Mazariegos G,Webber S,Girnita A

    更新日期：2009-08-01 00:00:00

  • Innate natural antibodies. Primary roles indicated by specific epitopes.

    abstract：:Two members of a unique class of natural antibodies have been identified in all of a large cohort of sera from clinically normal humans of broad age distribution. By means of a series of 10-12 mer peptides the epitope for each of those antibodies was characterized with regard to amino acid identity and conformation. S...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(97)00100-6

    authors： Rodman TC,To SE,Sullivan JJ,Winston R

    更新日期：1997-07-01 00:00:00

  • Use of a murine T-cell hybridoma expressing human T-cell receptor alpha- and beta-gene products as a tool for the production of human T-cell receptor-specific monoclonal antibodies.

    abstract：:We describe the production of mouse monoclonal antibodies specific for the human TcR using as the immunogen transfected murine T-cell hybridoma cells coexpressing mouse CD3 with human Jurkat TcR alpha and beta chains. The shortage of monoclonal antibodies (mAbs) specific for the human TcR-V alpha and V beta families r...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(92)90098-8

    authors： Zumla A,McCormack A,George A,Batchelor R,Lechler R

    更新日期：1992-11-01 00:00:00

  • Narcolepsy without unique MHC class II antigen association: studies in the canine model.

    abstract：:Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90067-0

    authors： Dean RR,Kilduff TS,Dement WC,Grumet FC

    更新日期：1989-05-01 00:00:00

  • Human immunodeficiency virus-1 infection protects against a Tc1-to-Tc2 shift in CD8(+) T cells.

    abstract：:Despite the reports of dysfunction of the lytic abilities of CD8(+) T cells during human immunodeficiency virus-1 (HIV-1) disease progression, the effects of infection on the noncytolytic functions of CD8(+) T cells have not been well characterized to date. We examined the effect of HIV-1 infection on the cytokine and...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.08.012

    authors： Gulzar N,Diker B,Balasubramanian S,Jiang JQ,Copeland KF

    更新日期：2011-11-01 00:00:00

  • Impact of pronase on flow cytometric crossmatch outcome.

    abstract：:Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.01.005

    authors： Hetrick SJ,Schillinger KP,Zachary AA,Jackson AM

    更新日期：2011-04-01 00:00:00

  • T-cell receptor V beta selectivity in T-cell clones alloreactive to HLA-Dw14.

    abstract：:The HLA-DR4 subtypes Dw14 and Dw4 are T-cell-defined allospecificities encoded by the DRB1*0404 and DRB1*0401 genes, respectively. Although these allelic subtypes differ in only two amino acids, allorecognition between Dw14 and Dw4-positive individuals is brisk. This provides an opportunity to analyze T-cell receptor ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(92)90052-o

    authors： Yamanaka K,Kwok WW,Mickelson EM,Masewicz S,Nepom GT

    更新日期：1992-01-01 00:00:00

  • Lack of evidence of association between IFNG and IL28B polymorphisms and QuantiFERON-CMV test results in seropositive transplant patients.

    abstract：:The aim of this study was to analyze the relationship between the IFNG +874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.03.009

    authors： Aguado R,Páez-Vega A,Agüera ML,Montejo M,Guirado L,Fortún J,Suárez-Benjumea A,Len O,Fariñas MC,de Gracia C,Hernández D,Cobos-Ceballos MJ,Torre-Cisneros J,Cantisán S,Spanish Network for Research in Infectious Diseases and the

    更新日期：2018-06-01 00:00:00