Abstract：
:The presence of complement fixing anti-human leukocyte antigen (HLA) antibodies in the circulation of organ transplant recipients may result in heart allograft rejection. Here, we assessed the clinical impact of pre- and post-transplantation allosensitization on long-term survival of heart allografts. Sequential samples of sera from heart allograft recipients were screened pretransplantation for panel reactive antibodies using the complement-dependent cytotoxicity test. Patients were monitored post-transplantation for donor specific anti-HLA class I and class II antibodies. Kaplan-Meier graft survival plots were generated to analyze the effect of anti-HLA antibodies on transplantation outcomes. Statistical analysis showed that the post-transplantation development of alloantibodies was a significant risk factor that was associated with low long-term survival rates; in contrast, recipients' gender, age, previous transplantations, and degree of HLA matching with the donor had no effect on long-term survival. The presence in pretransplantation sera of antibodies against more than 10% of the HLA reference panel (PRA >10%) was associated with AMR and with a relatively lower rate of graft survival after 1 year but did not affect 10-year survival. The present data underline the importance of monitoring the development of anti-HLA antibodies as a tool for early diagnosis and treatment of AMR.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Ho EK,Vlad G,Colovai AI,Vasilescu ER,Schwartz J,Sondermeijer H,Burke E,Marboe CC,Itescu S,Suciu-Foca N,Mancini Ddoi
10.1016/j.humimm.2009.06.015subject
Has Abstractpub_date
2009-10-01 00:00:00pages
825-9issue
10eissn
0198-8859issn
1879-1166pii
S0198-8859(09)00161-Xjournal_volume
70pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract：:Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.01.011
更新日期：2007-05-01 00:00:00
abstract：:From a human cDNA library constructed from consanguineous HLA-homozygous cell line AKIBA (HLA-A24, Bw52, DR2, Dw12, Cp63 Cp63: a new DP type), cDNA clones encoding the heavy and light chains of an HLA-DP Cp63 alloantigen were isolated and analyzed by restriction enzyme mapping and nucleotide sequence determination. Al...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(86)90286-7
更新日期：1986-11-01 00:00:00
abstract：:Pronase treatment of lymphocytes is used to reduce nonspecific binding of immunoglobulins in flow cytometric crossmatch (FCXM) tests and at higher concentrations to remove CD20 from the cell surface. We examined the effect of pronase treatment on human leukocyte antigen (HLA) expression and on FCXM results. Lymphocyte...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2011.01.005
更新日期：2011-04-01 00:00:00
abstract：:Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2014.06.009
更新日期：2014-08-01 00:00:00
abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2007.09.003
更新日期：2007-11-01 00:00:00
abstract：:The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2012.06.002
更新日期：2012-09-01 00:00:00
abstract：:TCR V alpha 3 and V alpha 5 transcripts in PBLs from healthy individuals of multiple age groups and from BMT recipients were analyzed. PCR, cloning, and sequencing studies revealed significant V-J junctional diversity among TCR transcripts from all tested blood samples, as provided both by N/P-region addition and exon...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90183-2
更新日期：1993-07-01 00:00:00
abstract：:The role of donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) in lung allograft rejection has been recognized over the past 20 years. During this time, there has been growing experience and recognition of an important role for non-HLA antibodies in lung allograft rejection. Multiple self-ant...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2019.04.008
更新日期：2019-08-01 00:00:00
abstract：:Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-r...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2015.03.005
更新日期：2015-05-01 00:00:00
abstract：:We previously investigated the characteristics of renal allograft infiltrating T-cell lines that were propagated from biopsy and nephrectomy specimens designated as IG-Bip and IG-Neph, respectively, or analogous line designated IG-T-eff, which was generated by co-culturing pretransplant recipient blood with irradiated...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00077-4
更新日期：1995-02-01 00:00:00
abstract：:The HLA-B5,B35 cross-reacting group is a large and serologically complex antigen family which includes the World Health Organization-recognized specificities HLA-B5,B51,Bw52,B35,Bw53,B18,Bw70,Bw71, and Bw72. In addition, several variants of antigens in this cross-reacting group have been described in the past but have...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(89)90035-9
更新日期：1989-11-01 00:00:00
abstract：:Analysis of the MICA gene revealed a trinucleotide repeat (GCT) microsatellite polymorphism within the transmembrane region. So far, seven alleles of the exon 5 of the MICA gene, which consist of 4, 5, 6, 7, 9, and 10 repetitions of GCT or five repetitions of GCT with an additional nucleotide insertion (GGCT), have be...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2006.10.007
更新日期：2006-12-01 00:00:00
abstract：:Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine th...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2010.02.010
更新日期：2010-06-01 00:00:00
abstract：:The modified mixed leukocyte reaction (MMLR) test consists of the standard MLR (SMLR) test to which interleukin-4 (IL-4) has been added. It is a sensitive procedure capable of detecting alloreactivity not detected by the SMLR. In the present study we applied the MMLR test to unrelated bone marrow transplantation (BMT)...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00065-8
更新日期：1999-09-01 00:00:00
abstract：:Positive selection of immature thymocytes is a developmental process in which TCR ligation with low avidity induces generation of mature T cells. In mouse thymocytes, CD4(+)8(+) double-positive (DP) cells which were treated with a proper combination of calcium ionophore ionomycin and phorbol 12-myristate 13-acetate (P...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00276-2
更新日期：2001-08-01 00:00:00
abstract：:Constitutive expression of major histocompatibility complex (MHC) class II molecules by duodenal epithelial cells (EC) suggests that they can present antigen to CD4(+) T cells. However, other molecular components including invariant chain (Ii), HLA-DM, and costimulatory molecules CD80, CD86 and CD40, are required for ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(02)00436-6
更新日期：2002-11-01 00:00:00
abstract：:Killer cell immunoglobulin-like receptor (KIR) genes constitute a multigene family whose genomic diversity is achieved through variation in gene content and allelic polymorphism within individual KIR genes. To date, 16 KIR genes and pseudogenes have been identified, and group A and group B haplotypes are characterized...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2004.10.013
更新日期：2005-02-01 00:00:00
abstract：:Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(99)00102-0
更新日期：1999-11-01 00:00:00
abstract：:Natural antigen processing and presentation of antigen is thought to be important for the generation of a broad functional repertoire of antigen-specific T cells. In this study, the T-cell repertoire to an immunodominant human leukocyte antigen A2 (HLA-A2) binding peptide epitope of HER-2/neu, p369-377, was examined i...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(02)00401-9
更新日期：2002-07-01 00:00:00
abstract：:PCR-based analyses were performed for the identification of HLA-B44 subgroups. Genomic DNA from six homozygous cell lines and 44 healthy individuals who had serologically tested positive for HLA-B44 was investigated for polymorphism in exons 2 and 3 of the HLA-B44 genes. Two primers were designed for specific amplific...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(94)00071-w
更新日期：1995-01-01 00:00:00
abstract：:Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(93)90128-n
更新日期：1993-04-01 00:00:00
abstract：:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(00)00179-8
更新日期：2000-10-01 00:00:00
abstract：:Human T suppressor cells (Ts), capable of preventing autologous T helper cells (Th) from reacting against xenogeneic pig endothelial cells and pig APC can be generated in vitro. Ts derive from a population of CD3(+)CD8(+)CD28(-) T lymphocytes and specifically recognize the MHC class I antigens of the APC used for in v...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/s0198-8859(01)00238-5
更新日期：2001-05-01 00:00:00
abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and h...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2019.06.007
更新日期：2020-09-01 00:00:00
abstract：:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2016.01.003
更新日期：2016-09-01 00:00:00
abstract：:This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were ...
journal_title：Human immunology
pub_type： 杂志文章,评审
doi：10.1016/j.humimm.2008.07.018
更新日期：2008-11-01 00:00:00
abstract：:The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific antibodies (DSA) for acute rejection, bile duct complications or even graft loss. ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2018.04.009
更新日期：2018-07-01 00:00:00
abstract：:To identify disease-specific T cell changes that occur in Crohn's disease (CD) the T-cell receptor (TCR) BV repertoires of lamina propria lymphocytes (LPL) from both disease-active and disease-inactive colonic tissue of three CD patients were compared by a quantitative polymerase chain reaction (qPCR) and CDR3 length ...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/0198-8859(96)00079-1
更新日期：1996-06-01 00:00:00
abstract：:LMP2/LMP7 gene (LMP, low molecular mass protein) perform a critical role in the foreign antigen processing via the major histocompatibility complex-I (MHC-I) complex CD8(+) cytotoxic T lymphocytes (CTL) pathway. This study was designed to investigate whether the sequence variants in LMP2/LMP7 gene would increase the r...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.12.006
更新日期：2014-03-01 00:00:00
abstract：:Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymp...
journal_title：Human immunology
pub_type： 杂志文章
doi：10.1016/j.humimm.2013.01.011
更新日期：2013-05-01 00:00:00
