Abstract:
:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present evidence implicates HLA-DQ as the major susceptibility locus in IDDM, as class I expression apparently plays a role in the progression of disease, the possibility exists that the association attributed to HLA-DQ is in fact due to an association with the TAP genes. Several studies have concluded that the alleles of TAP1 are not significantly associated with IDDM; this report concentrates on the more telomeric TAP2 locus. During this investigation, six previously described TAP2 alleles were identified in 208 normal Caucasians and 241 Caucasian diabetics. Sequence analysis of cDNA clones identified a seventh allele of TAP2, TAP2*F, which contains an arginine-to-cystine interchange at amino acid position 651. Overall, our results indicate only a modest association of IDDM with TAP2; however, the newly described TAP2*F allele was found to be significantly increased in a modest subset of our large diabetic population. These data, generated from the same population of controls and diabetics we previously studied at all other relevant MHC loci, provide additional evidence that the HLA susceptibility to IDDM maps to HLA-DQ.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Jackson DG,Capra JDdoi
10.1016/0198-8859(94)00124-9subject
Has Abstractpub_date
1995-05-01 00:00:00pages
57-65issue
1eissn
0198-8859issn
1879-1166pii
0198885994001249journal_volume
43pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::Accurate identification of HLA antibodies using the single antigen bead (SAB) assay is critical for assessment of pre/post-transplant immunological risk and successful virtual crossmatching. Unfortunately, high titer HLA antibodies can be missed or underestimated in the SAB assay as a result of interference with the d...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.04.019
更新日期:2019-07-01 00:00:00
abstract::The relevance of pre-existing HLA-antibodies (HLA-Ab) in liver transplantation (LTx) is controversial. While livers are allocated without HLA match or preoperative crossmatch testing, several studies point to an impact of donor specific antibodies (DSA) for acute rejection, bile duct complications or even graft loss. ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.04.009
更新日期:2018-07-01 00:00:00
abstract::Recent data puts WNT signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. The key effectors in the WNT signaling pathway are low-density lipoprotein receptor-related protein 5 (LRP5), transcription factor 7-like 2 (TCF7L2), and downstream-r...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.03.005
更新日期:2015-05-01 00:00:00
abstract::The MHC in humans is a much studied region of the genome, the genes of which display a high rate of polymorphism and a high rate of linkage disequilibrium. Four families in which intra-class-I recombination has occurred have been analyzed with six polymorphic markers between HLA-A and -B in order to determine the full...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90530-e
更新日期:1993-10-01 00:00:00
abstract::The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.012
更新日期:2009-10-01 00:00:00
abstract::Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.03.018
更新日期:2006-01-01 00:00:00
abstract::Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00200-7
更新日期:2000-11-01 00:00:00
abstract::PCR-based analyses were performed for the identification of HLA-B44 subgroups. Genomic DNA from six homozygous cell lines and 44 healthy individuals who had serologically tested positive for HLA-B44 was investigated for polymorphism in exons 2 and 3 of the HLA-B44 genes. Two primers were designed for specific amplific...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)00071-w
更新日期:1995-01-01 00:00:00
abstract::Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(88)90015-8
更新日期:1988-09-01 00:00:00
abstract::An HLA-E polymorphism study by oligotyping and DNA sequencing was carried out in the Spanish population. As a result, a new HLA-E allele (E*01031) initially assigned by polymerase chain reaction oligotyping as E*0104 was found. This allele presents a synonymous change at codon 77 (AAT-->AAC; Asn) when compared with th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00008-6
更新日期:1997-04-15 00:00:00
abstract::Recent epidemiologic and phylogenetic analyses suggest that in the human population human immunodeficiency virus (HIV-1) is a relatively new pathogen that arose by zoonotic transmission from chimpanzees. In humans the morbidity and mortality figures due to HIV infection are extremely high. In a very small percentage o...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00088-0
更新日期:2003-07-01 00:00:00
abstract::The role of HLA-G in several clinical conditions related to reproduction has been investigated. Important polymorphisms have been found within the 5'URR and 3'UTR regions of the HLA-G promoter. The aim of the present study was to investigate 16 SNPs in the 5'URR and 14-bp insertion/deletion (ins/del) polymorphism loca...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.06.002
更新日期:2012-09-01 00:00:00
abstract::A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.05.004
更新日期:2019-07-01 00:00:00
abstract::T lymphoblasts sensitized in vitro to tetanus toxoid (TT) in 6 day cultures, acquire the capacity of stimulating the blastogenic response of "resting" autologous T lymphocytes in primary AMLC reactions. The response of lymphocytes primed against autologous-TT-sensitized-lymphoblasts (ATTSL) seems to be specific for id...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(84)90005-3
更新日期:1984-01-01 00:00:00
abstract::The HLA-DR4 subtypes Dw14 and Dw4 are T-cell-defined allospecificities encoded by the DRB1*0404 and DRB1*0401 genes, respectively. Although these allelic subtypes differ in only two amino acids, allorecognition between Dw14 and Dw4-positive individuals is brisk. This provides an opportunity to analyze T-cell receptor ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90052-o
更新日期:1992-01-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in the T-cell receptor (TCR) gene segments might play a role in shaping the TCR repertoire. Three polymorphisms have been described for the TCRBV20S1 gene segment, one of which is responsible for a nucleotide substitution at position 524, resulting in the introduction of a stop c...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.01.011
更新日期:2007-05-01 00:00:00
abstract::It is not clear whether CD3 contacts CD4 or CD8 directly, nor have the regulation and interregulation of expression of these three receptor molecules been determined. We explored these issues by first stimulating human peripheral blood lymphocytes in vitro with three well-characterized T-cell receptor-directed mitogen...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00128-7
更新日期:2000-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver. We evaluated the association of alleles and genotypes of polymorphisms of IL-18 (-607C/A and -137G/C), IFN-γ (+874T/A) and TNF-α (-238G/A and -308G/A) with the risk and severity of HCC. One-hundred-and-twelve patients with HCC and 202 healthy co...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.04.029
更新日期:2013-08-01 00:00:00
abstract::Tuberculosis (TB) caused by Mycobacterium tuberculosis is a major cause of morbidity and mortality worldwide. Thus far, many candidate genes have been investigated for their possible association with TB. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) encoded by CD209 is the major receptor of M tuberculo...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.04.004
更新日期:2011-09-01 00:00:00
abstract::Prevention of rejection and the induction of transplantation tolerance are two related but separable phenomena that must both be considered in the analysis of the response to a transplanted organ. It is frequently hard to separate these phenomena in assessing the outcome of clinical transplants, because patients are r...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/0198-8859(96)00059-6
更新日期:1996-09-15 00:00:00
abstract::Pronase treatment is used in the flow cytometry crossmatch (FCXM) to prevent nonspecific antibody binding on B cells. However, we have observed unexpected positive results with pronase-treated T cells in human immunodeficiency virus (HIV)-infected patients. In this study, 25 HIV-infected patients without HLA antibodie...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.014
更新日期:2016-06-01 00:00:00
abstract::The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.10.004
更新日期:2016-01-01 00:00:00
abstract::Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.02.005
更新日期:2017-04-01 00:00:00
abstract::The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.05.001
更新日期:2017-01-01 00:00:00
abstract::CD8(+) T-cell responses to three human cytomegalovirus (CMV) pp65 epitopes were studied in panels of healthy seropositive HLA-A*02/HLA-B*07 individuals, and HLA-A*02 donors mismatched for HLA-B*07. The majority of the latter had significant responses to a HLA-A*02-restricted epitope within the CMV pp65 antigen. By con...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00028-4
更新日期:2003-04-01 00:00:00
abstract::The master player in the transcriptional regulation of major histocompatibility (MHC) class II genes is a factor known as the MHC class II transactivator (CIITA). In this study we searched for polymorphisms in the 5' and 3' ends of the human CIITA gene to assess whether or not there is an association between alleles o...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(01)00215-4
更新日期:2001-04-01 00:00:00
abstract::Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.012
更新日期:2010-04-01 00:00:00
abstract::In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(87)90018-8
更新日期:1987-12-01 00:00:00
abstract::From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(91)90071-g
更新日期:1991-01-01 00:00:00
abstract::The aim of this study was to assess the possible association of the functional (GT)(n) microsatellite polymorphism in the FOXP3 gene with predisposition to several autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease, and celiac disease. We...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2005.06.001
更新日期:2005-08-01 00:00:00