Idiotypic receptors for soluble antigens on human T lymphocyte clones.

abstract：:PCR-based analyses were performed for the identification of HLA-B44 subgroups. Genomic DNA from six homozygous cell lines and 44 healthy individuals who had serologically tested positive for HLA-B44 was investigated for polymorphism in exons 2 and 3 of the HLA-B44 genes. Two primers were designed for specific amplific...

journal_title：Human immunology

authors： Yao Z,Keller E,Scholz S,McNicholas A,Volgger A,Albert ED

更新日期：1995-01-01 00:00:00

abstract：:One of the most characteristic and, at the same time, puzzling features of the cellular immune response towards HIV-1 is represented by an early vigorous HIV-specific CD8+ CTL response that does not prevent disease progression in the vast majority of patients. In this context, there is a striking mismatch over the cou...

journal_title：Human immunology

authors： De Maria A,Moretta L

更新日期：2000-01-01 00:00:00

abstract：:Lymphatic filariasis (LF) is a parasitic disease caused by threadlike worms of the Brugia and Wuchereria species that live in the human lymphatic system. Regulatory T cells (Tregs) may play a key role in the pathogenesis of LF, and cytotoxic T-lymphocyte antigen-4 (CTLA4) expressed by Tregs is a potential candidate ge...

journal_title：Human immunology

authors： Idris ZM,Miswan N,Muhi J,Mohd TA,Kun JF,Noordin R

更新日期：2011-07-01 00:00:00

abstract：:The proteins synthesized in the cytosol are several thousand, and the number of peptides potentially able to be bound by class I molecules they can generate is therefore huge. On the other hand, the actual number of peptide-class I complexes required for CTL activation is around 200. We focused on the peptides bound b...

journal_title：Human immunology

authors： Frumento G,Molina F,Pernis B,Ferrara GB

更新日期：1994-09-01 00:00:00

abstract：:The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...

journal_title：Human immunology

authors： Sinkovits G,Szilágyi Á,Farkas P,Inotai D,Szilvási A,Tordai A,Rázsó K,Réti M,Prohászka Z

更新日期：2017-02-01 00:00:00

abstract：:The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...

journal_title：Human immunology

authors： Georgel P

更新日期：2016-11-01 00:00:00

abstract：:CD1 glycoproteins are a class of antigen presenting molecules that bind and present non-peptidic antigens (lipids and glycolipids) for immune recognition. CD1 polymorphisms, although limited, could have a critical role in antimicrobial, anticancer, and autoimmune responses and disease susceptibility. Ethnic difference...

journal_title：Human immunology

authors： Aureli A,Aboulaghras S,Oumhani K,Del Beato T,Sebastiani P,Colanardi A,El Aouad R,Ben El Barhdadi I,Piancatelli D

更新日期：2020-07-01 00:00:00

abstract：:To identify disease-specific T cell changes that occur in Crohn's disease (CD) the T-cell receptor (TCR) BV repertoires of lamina propria lymphocytes (LPL) from both disease-active and disease-inactive colonic tissue of three CD patients were compared by a quantitative polymerase chain reaction (qPCR) and CDR3 length ...

journal_title：Human immunology

authors： Gulwani-Akolkar B,Akolkar PN,Minassian A,McKinley M,Fisher S,Silver J

更新日期：1996-06-01 00:00:00

abstract：:Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...

journal_title：Human immunology

authors： Petermann I,Huebner C,Browning BL,Gearry RB,Barclay ML,Kennedy M,Roberts R,Shelling AN,Philpott M,Han DY,Ferguson LR

更新日期：2009-06-01 00:00:00

abstract：:To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlant...

journal_title：Human immunology

authors： Oumhani K,Canossi A,Piancatelli D,Di Rocco M,Del Beato T,Liberatore G,Aureli A,Benjoaud A,El Aouad R,Adorno D,Casciani CU

更新日期：2002-02-01 00:00:00

abstract：:When lymphocytes of healthy donors were incubated with penicillin and washed before HLA typing, the cytotoxic reactivity of some typing sera with their corresponding antigen was blocked. When the penicillin was added to the cytotoxicity assay at different times, competition between penicillin and alloantiserum for bin...

journal_title：Human immunology

authors： Claas FH,Runia-van Nieuwkoop R,van den Berge W,van Rood JJ

更新日期：1982-08-01 00:00:00

abstract：:Felty's syndrome (FS) is a rare complication of rheumatoid arthritis (RA) previously shown to be strongly associated with HLA-DR4 and less significantly with HLA-DQw7. To map more precisely the HLA locus responsible for susceptibility to FS, we have examined HLA-DR4 and DQ beta-chain polymorphisms in FS patients and c...

journal_title：Human immunology

authors： Lanchbury JS,Jaeger EE,Sansom DM,Hall MA,Wordsworth P,Stedeford J,Bell JI,Panayi GS

更新日期：1991-09-01 00:00:00

abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

journal_title：Human immunology

authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

更新日期：1991-11-01 00:00:00

abstract：:To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gen...

journal_title：Human immunology

authors： Lee YJ,Woo M,Nam JH,Baek J,Im CH,Lee EY,Lee EB,Park KS,Song YW

更新日期：2008-06-01 00:00:00

abstract：:The contributions of individual amino acids in the polymorphic beta chain and the conserved alpha chain of HLA-DR1 to influenza HA-specific DR1-restricted and anti-DR1 allospecific T-cell recognition were analyzed. The genes encoding HLA-DR1 were subjected to site-directed mutagenesis in order to introduce single amin...

journal_title：Human immunology

authors： Tuosto L,Karr RW,Fu XT,Olson RR,Cundari E,Piccolella E,Lechler R,Lombardi G

更新日期：1994-08-01 00:00:00

abstract：:HLA genotyping by polymerase chain reaction (PCR) has some inherent labor-intensive and effort-demanding limitations. To overcome them, we have developed a real-time PCR with hybridization probes approach able to obtain a medium-low resolution HLA-B genotyping with fewer tubes and probes and with a shorter time requir...

journal_title：Human immunology

authors： Faner R,Casamitjana N,Coll J,Caro P,Pujol-Borrell R,Palou E,Juan M

更新日期：2006-04-01 00:00:00

abstract：:Soluble human leukocyte antigen-G molecules (HLA-G5) can be found in the peripheral blood of healthy females and males, and in other body fluids. To identify cells secreting HLA-G5 we generated a rabbit antiserum against a peptide motif encoded by intron-4 of HLA-G (RaHLA-G/I-4). Utilizing this antiserum as capture an...

journal_title：Human immunology

authors： Rebmann V,Busemann A,Lindemann M,Grosse-Wilde H

更新日期：2003-11-01 00:00:00

abstract：:Peptide binding to HLA-DR molecules in intracellular compartments is facilitated by HLA-DM molecules, present in most types of antigen-presenting cells. Allorecognition of DR specificities represents a form of T cell recognition of the MHC-peptide complex which in some cases is influenced by peptide binding. DRA and D...

journal_title：Human immunology

authors： Drover S,Kovats S,Masewicz S,Blum JS,Nepom GT

更新日期：1998-02-01 00:00:00

abstract：:Childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL) is usually initiated in utero and is thought to progress to overt leukemia under the influence of delayed exposure to a common infection. Based on the hypothesis that polymorphic HLA-DP variants can restrict T-cell responses to infection, we previously ...

journal_title：Human immunology

authors： Taylor M,Bergemann TL,Hussain A,Thompson PD,Spector L

更新日期：2011-10-01 00:00:00

abstract：:A flow cytometric method of simultaneously screening both HLA Class I and Class II panel reactive antibodies (PRA) was developed using a pool of 30 different Class I and 30 different Class II microbeads coated with purified HLA antigens. The antibodies in the serum that react specifically to the coated HLA antigens ar...

journal_title：Human immunology

authors： Pei R,Wang G,Tarsitani C,Rojo S,Chen T,Takemura S,Liu A,Lee J

更新日期：1998-05-01 00:00:00

abstract：:The difficulty of molecular typing of the HLA class I genes and the relevance of the genes of this region to disease susceptibility and transplantation have provided an impetus to develop useful typing markers. We have characterized by polymerase chain reaction analysis a new highly informative CA repeat localized app...

journal_title：Human immunology

authors： Grimaldi MC,Clayton J,Pontarotti P,Cambon-Thomsen A,Crouau-Roy B

更新日期：1996-12-01 00:00:00

abstract：:We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of acti...

journal_title：Human immunology

authors： Poláková K,Kuba D,Russ G

更新日期：2004-02-01 00:00:00

abstract：:During HLA-DQ oligotyping, the presence of a novel HLA-DQB1 allele was suggested by a pattern of probe hybridization that was inconsistent with the presence of any possible combination of two known alleles. The nucleotide sequence of the second exon of the HLA-DQB1 gene was determined, revealing a novel HLA-DQB1 seque...

journal_title：Human immunology

authors： Fenske TS,Baxter-Lowe LA

更新日期：1992-03-01 00:00:00

abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

journal_title：Human immunology

authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

更新日期：1991-11-01 00:00:00

abstract：:Next-generation sequencing (NGS) at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1 and -DRB3/4/5 loci was performed on 282 healthy unrelated individuals from different major regions of Spain. High-resolution HLA genotypes defined by full sequencing of class I loci and extended coverage of class II loci were obta...

journal_title：Human immunology

authors： Montero-Martín G,Mallempati KC,Gangavarapu S,Sánchez-Gordo F,Herrero-Mata MJ,Balas A,Vicario JL,Sánchez-García F,González-Escribano MF,Muro M,Moya-Quiles MR,González-Fernández R,Ocejo-Vinyals JG,Marín L,Creary LE,Osoegawa K

更新日期：2019-07-01 00:00:00

abstract：:Routine HLA typing by serology has been supported by DNA or protein analysis of the respective molecules in cases when serologic typing was inconclusive or difficult to perform. DNA analysis by RFLP, SSO, or PCR amplification with SSP is a reliable tool for the identification of alleles. Because DNA sequences may now ...

journal_title：Human immunology

authors： Rozemuller EH,Bouwens AG,Bast BE,Tilanus MG

更新日期：1993-08-01 00:00:00

abstract：:Induced Treg with the phenotype CD4(+)CD25(+)Foxp3(+)IFNγ(+) were shown to be associated with good long-term graft outcome in renal transplant recipients and inhibition of allogeneic T-cell responses in vitro. In the present study, we investigated whether apoptosis and Fas/FasL-dependent pathways contribute to the inh...

journal_title：Human immunology

authors： Daniel V,Sadeghi M,Wang H,Opelz G

更新日期：2013-02-01 00:00:00

abstract：:Phagocytosis and catabolism of sheep red blood cells by human peripheral blood phagocytes were studied in 100 normal caucasoid subjects (44 males and 56 females). Both phenomena are highly reproducible, and their indices seem to be biological constants. There is no correlation between these two indices and the indices...

journal_title：Human immunology

authors： Legrand L,Rivat-Perran L,Huttin C,Dausset J

更新日期：1982-02-01 00:00:00

abstract：:Constitutive expression of major histocompatibility complex (MHC) class II molecules by duodenal epithelial cells (EC) suggests that they can present antigen to CD4(+) T cells. However, other molecular components including invariant chain (Ii), HLA-DM, and costimulatory molecules CD80, CD86 and CD40, are required for ...

journal_title：Human immunology

authors： Byrne B,Madrigal-Estebas L,McEvoy A,Carton J,Doherty DG,Whelan A,Feighery C,O'Donoghue DP,O'Farrelly C

更新日期：2002-11-01 00:00:00

abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...

journal_title：Human immunology

authors： Carrier CM,Mollen N,Rothman WC,Rodriguez de Cordoba S,Rey-Campos J,Ginsberg-Fellner F,Carpenter C,Rubinstein P

更新日期：1989-01-01 00:00:00