Specific nature of cellular immune responses elicited by chimpanzees against HIV-1.

abstract：:Virus-specific T cells have been shown to cross-react with allogeneic HLA (allo-HLA) at a clonal level. However, the impact of a single virus on the allorepertoire has never been investigated at the polyclonal level. We made an inventory of the incidence and specificity of allo-HLA-cross-reactive-virus-specific CD8+ T...

journal_title：Human immunology

authors： van den Heuvel H,van der Meer-Prins EMW,van Miert PPMC,Zhang X,Anholts JDH,Claas FHJ

更新日期：2019-02-01 00:00:00

abstract：:One hundred sixty-one DRB1*03 positive individuals from each of five U.S. population groups (Caucasoids, African Americans, Asians/Pacific Islanders, Hispanics, and Native Americans) were randomly selected from a database of 82,979 individuals. DRB1*03 alleles were identified by polymerase chain reaction-sequence-spec...

journal_title：Human immunology

authors： Tang TF,Wang J,Slack R,Lin YS,Li L,Heine U,Ng J,Hartzman RJ,Katovich Hurley C

更新日期：2002-03-01 00:00:00

abstract：:Gene copy number variation (CNV) of the CC Chemokine ligand 3-Like-1 (CCL3L1) gene located on chromosome 17q12 has been associated with many diseases, including viral infections and autoimmune diseases. High sequence homology between CCL3L1 and three other related genes within the same cluster, CCL3, CCL3L2, and CCL3L...

journal_title：Human immunology

authors： Perry RT,Nyaku MK,Aissani B,Shrestha S

更新日期：2014-08-01 00:00:00

abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

journal_title：Human immunology

authors： Nunez G,Stastny P

更新日期：1983-01-01 00:00:00

abstract：:Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell ...

journal_title：Human immunology

authors： Shah AS,Leffell MS,Lucas D,Zachary AA

更新日期：2009-02-01 00:00:00

abstract：:Using TCR-specific mAbs, we analyzed the TCR distribution in the CD4 and CD8 compartments of peripheral blood T cells from members of six families, including two which were informative for an HLA-B/DR crossover. TCR distribution in the CD4 compartment is influenced by MHC class II antigens as it was similar in the chi...

journal_title：Human immunology

authors： Reed EF,Tugulea SL,Suciu-Foca N

更新日期：1994-06-01 00:00:00

abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

journal_title：Human immunology

authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

更新日期：1997-09-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver. We evaluated the association of alleles and genotypes of polymorphisms of IL-18 (-607C/A and -137G/C), IFN-γ (+874T/A) and TNF-α (-238G/A and -308G/A) with the risk and severity of HCC. One-hundred-and-twelve patients with HCC and 202 healthy co...

journal_title：Human immunology

authors： Teixeira AC,Mendes CT Jr,Marano LA,Deghaide NH,Secaf M,Elias J Jr,Muglia V,Donadi EA,Martinelli AL

更新日期：2013-08-01 00:00:00

abstract：:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...

journal_title：Human immunology

authors： Xu DP,Shi WW,Zhang TT,Lv HY,Li JB,Lin A,Yan WH

更新日期：2016-09-01 00:00:00

abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...

journal_title：Human immunology

authors： Deulofeut H,Wilderson JL,Barron KS,Robinson MA

更新日期：1995-07-01 00:00:00

abstract：:It has been known for some time that transplant recipients may have antibodies to endothelial cells which are not detected on lymphocytes. However, little progress has been made in the analysis of these endothelial antigens. In the present experiments we have attempted to characterize endothelial cell surface antigens...

journal_title：Human immunology

authors： Qin Z,Zou Y,Lavingia B,Stastny P

更新日期：2013-11-01 00:00:00

abstract：:We have investigated the presentation and CTL recognition of an HLA A*1101-restricted CTL peptide epitope AVFDRKSDAK (AVF)(3), derived from the EBV nuclear antigen (EBNA) 4, in the context of alleles belonging to the A3-supertype, A*0101, 0301, 1101, 3101, 3301, and 6801. The peptide binds to a A*6801 molecule as effi...

journal_title：Human immunology

authors： Levitsky V,Liu D,Southwood S,Levitskaya J,Sette A,Masucci MG

更新日期：2000-10-01 00:00:00

abstract：:CD3+CD20+ T cells are a population of CD3+ T cells co-expressing CD20 that make up to ∼3-5% of the CD3+ T-cell compartment in the peripheral blood of human beings. In healthy individuals, CD3+CD20+ T cells are heterogeneous for containing a lower proportion of CD4+ cells, but produce higher levels of IL-17A and/or IFN...

journal_title：Human immunology

authors： Chen Q,Yuan S,Sun H,Peng L

更新日期：2019-03-01 00:00:00

abstract：:Killer immunoglobulin-like receptors (KIRs) regulate function of NK cells and subsets of T cells. HLA class I molecules are ligands for inhibitory KIRs while specificity of activating KIRs is mainly unknown. Both KIR and HLA genotypes are highly polymorphic. In this study we analyzed associations of KIR and KIR ligand...

journal_title：Human immunology

authors： Giebel S,Boratyn-Nowicka A,Karabon L,Jedynak A,Pamula-Pilat J,Tecza K,Kula D,Kowal M,Frydecka I,Grzybowska E

更新日期：2014-06-01 00:00:00

abstract：:To test the involvement of osteopontin gene (OPN) in systemic sclerosis (SSc) susceptibility, two OPN single nucleotide polymorphisms previously reported to be associated with systemic lupus erythematosus, namely -156G/GG (proximal promoter) and +1239A/C (3' untranslated region (UTR)), were tested in 357 Italian patie...

journal_title：Human immunology

authors： Barizzone N,Marchini M,Cappiello F,Chiocchetti A,Orilieri E,Ferrante D,Corrado L,Mellone S,Scorza R,Dianzani U,D'Alfonso S

更新日期：2011-10-01 00:00:00

abstract：:Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive properties. Changing concentrations of transcriptional cofactors or chemicals in transiently transfected tissue culture cells modify several properties of glucocorticoid receptor-regulated gene expression including total activity (A(max)...

journal_title：Human immunology

authors： Luo M,Simons SS Jr

更新日期：2009-10-01 00:00:00

abstract：:Recipients of marrow grafts from HLA-identical, (including MLC non-reactive) sibling donors have a 40-50% incidence of acute graft vs. host disease (GVHD); the involvement of non-HLA linked, minor histocompatibility antigens (miHA) has been implicated. One of the target tissues of GVHD is the skin where morphological ...

journal_title：Human immunology

authors： Reinsmoen NL,Kersey JH,Bach FH

更新日期：1984-12-01 00:00:00

abstract：:The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to inve...

journal_title：Human immunology

authors： de Lima RE,de Holanda Martins CM,do Carmo RF,Aroucha DCBL,Pereira LMMB,Vasconcelos LRS,Moura P

更新日期：2018-09-01 00:00:00

abstract：:The aim of this study was to analyze the relationship between the IFNG +874 T/A and IL28B (rs12979860) C/T polymorphisms and the secretion of IFNG by CD8+ T cells after stimulation with cytomegalovirus (CMV) peptides, measured using QuantiFERON-CMV (QF-CMV) assay. A total of 184 CMV-seropositive solid organ transplant...

journal_title：Human immunology

authors： Aguado R,Páez-Vega A,Agüera ML,Montejo M,Guirado L,Fortún J,Suárez-Benjumea A,Len O,Fariñas MC,de Gracia C,Hernández D,Cobos-Ceballos MJ,Torre-Cisneros J,Cantisán S,Spanish Network for Research in Infectious Diseases and the

更新日期：2018-06-01 00:00:00

abstract：:We have investigated the polymorphism of TAP genes and the distribution of human leukocyte antigen (HLA)-TAP haplotypes in 90 Korean families (180 parents and 233 children), previously typed for HLA class II alleles. TAP1 (codons 333 and 637) and TAP2 (codons 379, 565, 577, 651, 665, and 687) typings were carried out ...

journal_title：Human immunology

authors： Whang DH,Park H,Roh EY,Park MH

更新日期：2005-09-01 00:00:00

abstract：:Swine-origin H1N1 influenza virus (S-OIV) appeared in 2009 with a higher incidence rate among children. Although fever was the most common symptom, some complicated cases occurred. We evaluated the percentages of effector T cells, B cells, and regulatory T cells in peripheral blood from 5 children infected by S-OIV (1...

journal_title：Human immunology

authors： Frisullo G,Iorio R,Plantone D,Nociti V,Patanella AK,Marti A,Palermo C,Valentini P,Mariotti P,Batocchi AP

更新日期：2011-08-01 00:00:00

abstract：:Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...

journal_title：Human immunology

authors： Snoussi K,Mahfoudh W,Bouaouina N,Ahmed SB,Helal AN,Chouchane L

更新日期：2006-01-01 00:00:00

abstract：:Despite advances in HLA matching, graft failure remains a serious complication after allogeneic hematopoietic cell transplantation (HCT). Pre-formed anti-HLA donor-specific antibodies (DSAs) have been associated with graft failure, but the impact of newly developing (de novo) anti-HLA antibodies on HCT outcomes remain...

journal_title：Human immunology

authors： Hefazi M,Hogan WJ,Wakefield LL,Gandhi MJ

更新日期：2018-12-01 00:00:00

abstract：:Basophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma, chronic allergy and lupus. Notably, Th17 cells are also implicated in the pathogenesis...

journal_title：Human immunology

authors： Sharma M,Stephen-Victor E,Poncet P,Kaveri SV,Bayry J

更新日期：2015-03-01 00:00:00

abstract：:The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

journal_title：Human immunology

authors： Nordwig H,Kwok WW,Johnson JP

更新日期：1991-06-01 00:00:00

abstract：:Two biallelic polymorphisms, previously described in the human intercellular adhesion molecule (ICAM)-1 gene at codon 241 (glycine [G] to arginine [R] substitution) and codon 469 (glutamic acid [E] to lysine [K] substitution) have been associated with a number of diseases including myocardial infarction, transplant re...

journal_title：Human immunology

authors： Holder AL,Wolf S,Walshe C,Pandya P,Stanford RE,Smith JD,Rose ML,Lawson C

更新日期：2008-02-01 00:00:00

abstract：:Polymorphism in the URR of the MHC class II DQA1 gene defines ten different alleles named QAP. Oligotyping for the alleles of DRB1, QAP, DQA1, and DQB1 have been performed in 210 unrelated healthy controls from Germany. Moreover, 83 HTCs from the Tenth IHWS have been tested. Four point loci haplotypes (DRB1, QAP, DQA1...

journal_title：Human immunology

authors： Haas JP,Kimura A,Andreas A,Hochberger M,Keller E,Brünnler G,Bettinotti MP,Nevinny-Stickel C,Hildebrandt B,Sierp G

更新日期：1994-01-01 00:00:00

abstract：:Our objective was to study a possible contribution of MHC genes to S-HLA-I secretion in patients with Type I diabetes. Quantitatively, we used a highly sensitive enzyme-linked immunoassay to measure S-HLA-I in the serum of a total of 39 patients with Type I diabetes, as well as 36 kinships of 12 diabetic patients and ...

journal_title：Human immunology

authors： Adamashvili I,McVie R,Gelder F,Gautreaux M,Jaramillo J,Roggero T,McDonald J

更新日期：1997-07-01 00:00:00

abstract：:During HLA-DQ oligotyping, the presence of a novel HLA-DQB1 allele was suggested by a pattern of probe hybridization that was inconsistent with the presence of any possible combination of two known alleles. The nucleotide sequence of the second exon of the HLA-DQB1 gene was determined, revealing a novel HLA-DQB1 seque...

journal_title：Human immunology

authors： Fenske TS,Baxter-Lowe LA

更新日期：1992-03-01 00:00:00

abstract：:It has been reported that collagen II (CII) derived peptide CII263-272 induced T-cell activation via its amino acids responsible for T-cell receptor (TCR) recognition. The impact of substitution of the TCR contacting amino acids of CII263-272 on T-cell activation was evaluated in this study using a panel of altered CI...

journal_title：Human immunology

authors： Zhou Q,Cheng Y,Lü H,Zhou W,Li Z

更新日期：2003-09-01 00:00:00