Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis.

abstract：:Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene frequencies were calculated by direct counting of the number of p...

journal_title：Human immunology

authors： Castro-Santos P,Verdugo RA,Díaz-Peña R

更新日期：2018-09-01 00:00:00

abstract：:Cumulative evidence indicates that the human interleukin-4 receptor alpha chain gene (IL-4Ralpha, CD124) is highly polymorphic in contrast to other cytokine receptor genes. Our group recently identified the IL-4Ralpha variant R551 as being strongly associated with decreased kidney allograft survival. Due to the key im...

journal_title：Human immunology

authors： Hackstein H,Hofmann H,Bohnert A,Bein G

更新日期：1999-11-01 00:00:00

abstract：:IDDM is known to be associated with genes of HLA complex, particularly alleles of HLA-DQ. The 40-kb TAP gene complex is located approximately 150 kb centrometric to the DQB1 locus. The TAP1-TAP2 protein heterodimer is required for normal expression levels of class I, molecules on the surface of cells. While present ev...

journal_title：Human immunology

authors： Jackson DG,Capra JD

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:When donor specific HLA antibodies (DSA) are identified, the predictive value of whether a certain strength of reactivity (mean fluorescence intensity, MFI) leads to a positive crossmatch is uncertain. To determine this, we compared the DSA MFI results we generated locally for nationally distributed proficiency...

journal_title：Human immunology

authors： Wrenn SM,Marroquin CE,Hain DS,Harm SK,Pineda JA,Hammond PB,Shah DH,Hillyard SE,Fung MK

更新日期：2018-08-01 00:00:00

abstract：:It has been suggested that MEVF mutations offer advantage against infections, including tuberculosis. Bearing in mind the central role of TLR-2 and TLR-4 in the recognition of pathogens, we conducted this study to examine whether the TLR2-R753Q, TLR4-D299G, TLR4-T399I common polymorphisms are associated with susceptib...

journal_title：Human immunology

authors： Speletas M,Kalala F,Mitroulis I,Papadopoulos V,Merentiti V,Germenis AE,Ritis K

更新日期：2009-09-01 00:00:00

abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two E...

journal_title：Human immunology

authors： Juárez-Nicolás F,Barquera R,Martínez-Álvarez JC,Hernández-Zaragoza DI,Ortega-Yáñez A,Arrieta-Bolaños E,Clayton S,Bravo-Acevedo A,Arrazola-García MA,Immel A,Juárez-Barreto V,Benítez-Arvizu G,Vega-Martínez MDR,García-Álvarez R,

更新日期：2020-09-01 00:00:00

abstract：:Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...

journal_title：Human immunology

authors： Matte C,Lacaille J,Zijenah L,Ward B,Roger M

更新日期：2000-11-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a well-known cause of disease occurring after bone marrow transplantation (BMT). The manifestations of CMV range from asymptomatic infection, defined as active CMV replication in the blood in the absence of clinical manifestations or organ failure abnormalities, to CMV disease, characterized b...

journal_title：Human immunology

authors： Castagnola E,Cappelli B,Erba D,Rabagliati A,Lanino E,Dini G

更新日期：2004-05-01 00:00:00

abstract：:In this study, we evaluated the leukocyte density and composition in the human cycling endometrium with uterine fibroids (UF). The endometrium with neighboring nodule (NN group, n = 62), autologous endometrium without NN (non-NN group, n = 62), and allogeneic endometrium without UF (non-UF group, n = 24) were immunost...

journal_title：Human immunology

authors： Kitaya K,Yasuo T

更新日期：2010-02-01 00:00:00

abstract：:The purpose of this article is to study the amounts of gamma-aminobutyric acid-transaminase (GABA-t) during immune response in the human thymus. GABA-t was studied by biochemical and histochemical methods in 7 immunostimulated (treated) and 7 non-immunostimulated (untreated) patients (4 young adult, age range: 24-36 y...

journal_title：Human immunology

authors： Cavallotti D,Artico M,D'Andrea V,Cavallotti C

更新日期：2000-07-01 00:00:00

abstract：:HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of...

journal_title：Human immunology

authors： Obata F,Endo T,Yoshii M,Otani F,Igarashi M,Takenouchi T,Ikeda H,Ogasawara K,Kasahara M,Wakisaka A

更新日期：1985-09-01 00:00:00

abstract：:Two hundred and three sera obtained from multiparous women were screened to determine the frequency of the appearance of antibodies reactive with PHA-activated T lymphocytes, but not with resting B or T cells from the same donor. The panel of cells on which the sera were tested consisted of lymphocytes from 38 unrelat...

journal_title：Human immunology

authors： Kim SJ,Christiansen FT,Gosar I,Silver DM,Pollack MS,Dupont B

更新日期：1980-12-01 00:00:00

abstract：:The combined interferon-alpha (IFN-alpha) and ribavirin (IFN-alpha/ribavirin) therapy for chronic hepatitis C virus (HCV) infection results in sustained viral eradication in 31%-64% of the patients. Previous studies have strongly suggested that HCV-specific T-cell responses maybe modulated during this therapy. The obj...

journal_title：Human immunology

authors： Sreenarasimhaiah J,Jaramillo A,Crippin J,Lisker-Melman M,Chapman WC,Mohanakumar T

更新日期：2003-05-01 00:00:00

abstract：:From a human cDNA library constructed from consanguineous HLA-homozygous cell line AKIBA (HLA-A24, Bw52, DR2, Dw12, Cp63 Cp63: a new DP type), cDNA clones encoding the heavy and light chains of an HLA-DP Cp63 alloantigen were isolated and analyzed by restriction enzyme mapping and nucleotide sequence determination. Al...

journal_title：Human immunology

authors： Ando A,Inoko H,Kimura M,Ogata S,Tsuji K

更新日期：1986-11-01 00:00:00

abstract：:It has been known for some time that transplant recipients may have antibodies to endothelial cells which are not detected on lymphocytes. However, little progress has been made in the analysis of these endothelial antigens. In the present experiments we have attempted to characterize endothelial cell surface antigens...

journal_title：Human immunology

authors： Qin Z,Zou Y,Lavingia B,Stastny P

更新日期：2013-11-01 00:00:00

abstract：:A case-control study was performed to establish a potential association of two TNF-α gene promoter SNPs (-238G>A and -308G>A) with occurrence of type 1 Diabetes mellitus (T1DM) in Croatian population (174 patients and 193 healthy controls). Genotypes (obtained by polymerase chain reaction-restriction fragment length p...

journal_title：Human immunology

authors： Korolija M,Hadžija M,Medvidović EP,Pavkovic P,Kapitanović S,Renar IP,Hadžija MP

更新日期：2010-12-01 00:00:00

abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

journal_title：Human immunology

authors： Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

更新日期：2013-05-01 00:00:00

abstract：:DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to ...

journal_title：Human immunology

authors： Grifoni A,Sidney J,Carpenter C,Phillips E,Mallal S,Scriba TJ,Sette A,Lindestam Arlehamn CS

更新日期：2018-03-01 00:00:00

abstract：:Novel therapeutic strategies such as the modulation of dendritic cell and T-cell function have exhibited great potential in clinical transplantation. Human leukocyte antigen (HLA)-G is a molecule that plays a significant role in establishing complex mechanisms to protect semiallogeneic fetuses from rejection by the ma...

journal_title：Human immunology

authors： Wu J,Zhang W,Hernandez-Lopez P,Fabelo E,Parikh M,Mulloy LL,Horuzsko A

更新日期：2009-12-01 00:00:00

abstract：:A panel of 34 clones was established from a cell line derived from the skin biopsy of a patient (genotype: A1, A2, B7, B8, DR3, DR6) undergoing acute graft-versus-host disease after semiallogeneic bone marrow transplantation with his mother's bone marrow (genotype: A1, A1, B7, B8, DR3, DR6). The T-cell line obtained p...

journal_title：Human immunology

authors： Vié HP,Millpied N,Devilder MC,Mahe B,Hallet MM,Moreau JF,Soulillou JP

更新日期：1990-10-01 00:00:00

abstract：:DNA sequences that distinguish the subsets of HLA-DR4 are also found on several other alleles. This makes typing of heterozygotes with oligonucleotide probes quite impractical. We have therefore developed a procedure in which, in a first step, DNA of the genes to be analyzed is amplified selectively, using group-speci...

journal_title：Human immunology

authors： Gao XJ,Fernandez-Vina M,Shumway W,Stastny P

更新日期：1990-01-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disorder characterized by fatigability and weakness of striated muscles. Its association with HLA molecules is well known and varies depending on age, sex and the ethnicity of the patients. A case-control study was performed in 61 Cuban patients and 81 controls using polymeras...

journal_title：Human immunology

authors： Sylvia T,Samuel M,Luis G,Zuzet M

更新日期：2013-08-01 00:00:00

abstract：:The development of solid phase immunoassays using solubilized HLA molecules as targets has provided a means of detecting HLA-specific antibodies that overcomes many of the shortcomings of lymphocyte based assays. We have evaluated a commercially available assay, the GTI QuikID (QID), that uses solubilized class I mole...

journal_title：Human immunology

authors： Zachary AA,Delaney NL,Lucas DP,Leffell MS

更新日期：2001-03-01 00:00:00

abstract：:Activation of Toll-like receptors (TLR) seems to be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Upon TLR activation the release of defensins, including human beta defensin 2 (HBD-2), may occur. In this study, we explored the innate responses in patients with respiratory failure, with ...

journal_title：Human immunology

authors： Pace E,Giarratano A,Ferraro M,Bruno A,Siena L,Mangione S,Johnson M,Gjomarkaj M

更新日期：2011-01-01 00:00:00

abstract：:We have found that 4H84 monoclonal antibody (mAb) used for detection of beta2m free HLA-G molecules also binds to free heavy chains of classical HLA class I antigens generated on the cell surface by mild acid treatment. Here we demonstrate that beta2m free classical HLA class I molecules induced on the surface of acti...

journal_title：Human immunology

authors： Poláková K,Kuba D,Russ G

更新日期：2004-02-01 00:00:00

abstract：:Using a large battery of Bw16, w38, and w39 antisera, a new variant of Bw16 has been identified in four unrelated Mexican-American families. The serologic pattern obtained is distinct from that for Bw38, Bw39, and 8W57 antigens. Absorption studies confirm the existence of this new Bw16 subtype which we term ST-16. ST-...

journal_title：Human immunology

authors： Ness DB,Watson AK,Grumet FC

更新日期：1982-02-01 00:00:00

abstract：:Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) w...

journal_title：Human immunology

authors： Potekhina AV,Provatorov SI,Sokolov VO,Pylaeva EA,Masenko VP,Noeva EA,Kukhtina NB,Krasnikova TL,Arefieva TI

更新日期：2011-07-01 00:00:00

abstract：:The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

journal_title：Human immunology

authors： Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

更新日期：1989-05-01 00:00:00

abstract：HLA A:B:C:DRB1:DQB1 allele and haplotype frequencies were determined among India, Andhra Pradesh, Telugu speaking population from South India by Next Generation Sequencing. 180 bone marrow registry donors and 6 cord blood units from Jeevan Stem Cell Foundation (part of Be The Cure Registry), Chennai, Tamilnadu state we...

journal_title：Human immunology

authors： Seshasubramanian V,Manisekar NK,Sathishkannan AD,Naganathan C,Narayan S

更新日期：2018-08-01 00:00:00

abstract：:The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rej...

journal_title：Human immunology

authors： Benichou G,Malloy KM,Tam RC,Heeger PS,Fedoseyeva EV

更新日期：1998-09-01 00:00:00