Abstract:
:Little is known about the etiologies of diseases associated with circulating antineutrophil cytoplasm autoantibodies (ANCA), such as primary vasculitides and inflammatory bowel diseases. However, the understanding of immune mechanisms supposedly involved in the pathogenesis of these diseases is still growing. In the present review, we first focus on the mechanisms triggering the development of ANCA, including the potential role of microbial superantigens and the possible defect(s) in the progression of apoptosis or in the removal of apoptotic cells. We next concentrate on the contribution of ANCA to the clinical symptoms and on the pathogenic role of ANCA, including the accessibility of ANCA antigens as targets for circulating antibodies and the mode of action of ANCA. Mechanisms of neutrophil activation by ANCA include the engagement of Fcgamma receptors, the possible mechanisms of neutrophil-mediated tissue damage, and the neutrophil-endothelial interaction.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Reumaux D,Duthilleul P,Roos Ddoi
10.1016/j.humimm.2003.09.013subject
Has Abstractpub_date
2004-01-01 00:00:00pages
1-12issue
1eissn
0198-8859issn
1879-1166pii
S019888590300586Xjournal_volume
65pub_type
杂志文章,评审相关文献
HUMAN IMMUNOLOGY文献大全abstract::While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.01.012
更新日期:2016-03-01 00:00:00
abstract::Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.06.006
更新日期:2010-10-01 00:00:00
abstract::Celiac disease (CD) patients are intolerant to gluten, proteins in wheat, and related cereals. Virtually all patients are human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 positive and several studies have demonstrated that CD4 T cells specific for (modified) gluten peptides bound to these HLA-DQ molecules are found in pat...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2006.03.011
更新日期:2006-06-01 00:00:00
abstract::Peptide binding to HLA-DR molecules in intracellular compartments is facilitated by HLA-DM molecules, present in most types of antigen-presenting cells. Allorecognition of DR specificities represents a form of T cell recognition of the MHC-peptide complex which in some cases is influenced by peptide binding. DRA and D...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(97)00263-2
更新日期:1998-02-01 00:00:00
abstract::CD4+ T cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class II-specific T-cell lines cultured and grown from previous biopsies. Fourteen of the CD4+ T-cell cultures were expanded and cloned using the same feeder cel...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90011-d
更新日期:1990-06-01 00:00:00
abstract::A typing system for HLA-D/DR-associated PLT-defined determinants, which have been called "DP" antigens, is reported. Some of the results concerning a data interpretation system, the reproducibility of PLT results, and the correlations between the results of HLA-D, -DR, and DP typing are presented. Also, a "new" human ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(81)90035-5
更新日期:1981-07-01 00:00:00
abstract::CD8(+) T-cell responses to three human cytomegalovirus (CMV) pp65 epitopes were studied in panels of healthy seropositive HLA-A*02/HLA-B*07 individuals, and HLA-A*02 donors mismatched for HLA-B*07. The majority of the latter had significant responses to a HLA-A*02-restricted epitope within the CMV pp65 antigen. By con...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00028-4
更新日期:2003-04-01 00:00:00
abstract::The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)90008-6
更新日期:1994-10-01 00:00:00
abstract::In previous studies, major histocompatibility complex (MHC) class II DP, DQ, and DR families of genes were characterized in different primate species mostly on the basis of their second exon sequences. Resemblances were found between Old World monkey (OWM) and New World monkey (NWM) genes and were interpreted as being...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00233-0
更新日期:2001-01-01 00:00:00
abstract::Sera obtained from multiparous women and some of other origin contain antibodies which react with antigens on T cell subsets. These antibodies recognize two distinct diallelic systems, one of which is mainly present on T gamma cells while the other is present on T mu cells. The sera that reacted with the T gamma cells...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90011-8
更新日期:1982-04-01 00:00:00
abstract::Phagocytosis and catabolism of sheep red blood cells by human peripheral blood phagocytes were studied in 100 normal caucasoid subjects (44 males and 56 females). Both phenomena are highly reproducible, and their indices seem to be biological constants. There is no correlation between these two indices and the indices...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90045-3
更新日期:1982-02-01 00:00:00
abstract::Accurate identification of HLA antibodies using the single antigen bead (SAB) assay is critical for assessment of pre/post-transplant immunological risk and successful virtual crossmatching. Unfortunately, high titer HLA antibodies can be missed or underestimated in the SAB assay as a result of interference with the d...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.04.019
更新日期:2019-07-01 00:00:00
abstract::Peptides derived from mutated human proto-oncogenes bound to HLA may represent a novel type of tumor-specific antigen. Mutated ras genes are the oncogenes most frequently identified in human cancer. The transforming genes carry a mutation in codons 12, 13, or 61. We have investigated whether the T-cell repertoire of h...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(92)90334-j
更新日期:1992-04-01 00:00:00
abstract::Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) w...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.03.015
更新日期:2011-07-01 00:00:00
abstract::Comparison of human leukocyte antigen (HLA) frequencies in patients with hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) and in patients with HCV-associated non-Hodgkin's lymphoma (NHL) has not been addressed previously. To this aim, we investigated the distribution of HLA class II alleles in two sel...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2004.08.183
更新日期:2004-11-01 00:00:00
abstract::In the present study, DNA typing for HLA-A, C, B, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 was performed for 246 healthy, unrelated Greek volunteers of 20-59 years of age. Phenotype, genotype frequencies, Hardy-Weinberg equilibrium fit, and 3-locus haplotype frequencies for HLA-A, C, B, HLA-A, B, DRB1, HLA-DRB1, D...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00115-4
更新日期:2000-06-01 00:00:00
abstract::Two hundred and three sera obtained from multiparous women were screened to determine the frequency of the appearance of antibodies reactive with PHA-activated T lymphocytes, but not with resting B or T cells from the same donor. The panel of cells on which the sera were tested consisted of lymphocytes from 38 unrelat...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(80)90110-x
更新日期:1980-12-01 00:00:00
abstract::Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of inflammatory bowel disease (IBD) in a New Zealand Caucasian case-cont...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.03.002
更新日期:2009-06-01 00:00:00
abstract::The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.04.004
更新日期:2016-11-01 00:00:00
abstract::Basophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma, chronic allergy and lupus. Notably, Th17 cells are also implicated in the pathogenesis...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2014.12.015
更新日期:2015-03-01 00:00:00
abstract::RING 11, a second transport-associated gene (TAP2), has been recently identified in the DR-DP interval of the human class II region. Two predominant alleles, TAP2A and TAP2B, differing by 17 amino acids at the C-terminus of the ATP-binding domain are present in the Caucasoid population at frequencies of 79% and 21%, r...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90544-b
更新日期:1993-11-01 00:00:00
abstract::A case-control study was performed to establish a potential association of two TNF-α gene promoter SNPs (-238G>A and -308G>A) with occurrence of type 1 Diabetes mellitus (T1DM) in Croatian population (174 patients and 193 healthy controls). Genotypes (obtained by polymerase chain reaction-restriction fragment length p...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.09.003
更新日期:2010-12-01 00:00:00
abstract::The expression pattern of several genes associated with different processes in melanocytes, including melanogenesis, is changed in vitiligo patients. We evaluated possible changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, IL29), their receptor subunits (IL20RB, IL22RA2, IL28RA), a...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.01.011
更新日期:2012-04-01 00:00:00
abstract::More insight into the differential immunogenicity of human leukocyte antigen (HLA) mismatches will be beneficial for donor selection in clinical transplantation. In this study the immunogenicity of HLA antigens was analyzed by examining the antibody profiles in women who have been pregnant. In total 888 women, who had...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(03)00058-2
更新日期:2003-06-01 00:00:00
abstract::We have produced a monoclonal antibody detecting an HLA class II determinant absent from DR1,2,W6, and W10 (DQW1) homozygous B lymphoblastoid cell lines (BLCL). The antibody, SFR16-PI.2, immunoprecipitates molecules with electrophoretic mobilities of DQ (DS/DC) molecules from DR7 homozygous cell lines. SFR16-PI.2 bind...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90229-0
更新日期:1985-11-01 00:00:00
abstract::When lymphocytes of healthy donors were incubated with penicillin and washed before HLA typing, the cytotoxic reactivity of some typing sera with their corresponding antigen was blocked. When the penicillin was added to the cytotoxicity assay at different times, competition between penicillin and alloantiserum for bin...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(82)90033-7
更新日期:1982-08-01 00:00:00
abstract::The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(89)90038-4
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:X-linked lymphoproliferative disease (XLP) is a rare life-threatening syndrome. Rapid recognition and definitive diagnosis are critical to improve the prognosis and survival of patients with XLP. Nowadays, little is known about patients with XLP in China. METHODS:We report the characterization of five Chine...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.06.005
更新日期:2016-08-01 00:00:00
abstract::Uninfected, as well as feline leukemia virus (FeLV) infected human cells cultured under high cell density conditions undergo changes in the expression of major histocompatibility complex (MHC) antigens, as determined by indirect trace binding radio immunoassay (RIA) using monoclonal anti-HLA antibodies and by decrease...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(83)80006-8
更新日期:1983-06-01 00:00:00
abstract::Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G polymorphisms are associated with human papillomavirus (HPV) infection susceptibility and persistence in 636 female university students in Montreal. HLA-...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.01.010
更新日期:2011-04-01 00:00:00