Genetic polymorphisms of interleukin-6 modulate fibrosis progression in mild chronic hepatitis C.

Abstract:

:Genetic polymorphisms of interleukin-6 (IL-6) (-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C) may affect the outcomes of several diseases. This study was aimed to verify the role of these polymorphisms on the disease progression of patients with hepatitis C virus (HCV) infection and persistently normal transaminases (PNALT). A total of 121 PNALT patients did not receive any antiviral treatment but underwent periodic clinical monitoring, including repeat biopsies, for a median of 120 months. IL6-1363G>T, -597G>A, -572G>C, -174G>C, +2954G>C polymorphisms were related to histologic fibrosis progression. Among patients whose grading and staging scores increased at the end of the follow-up ≥2 Ishak points (N = 60 and N = 26, respectively), IL-6 -174G>C genotype frequencies were GG 37/66, GC 21/45, CC 2/10 (p = 0.041) and GG 18/66, GC 8/45, CC 0/10 (p = 0.040), respectively. The following frequencies were observed for the 572G>C polymorphism: GG 50/105, GC 10/16, CC 0/0, and GG 19/105, GC 7/16, CC 0/0, respectively. Grading progression was independently associated with carriage of the G allele in -174G>C polymorphism (oddd ratio = 5.07%, 95% confidence interval = 0.959-26.8, p = 0.023). Staging progression was independently associated with carriage of the C allele in -572G>C polymorphism (odd ratio = 4.60%, 95% confidence interval 1.42-14.8, p = 0.012). IL-6 polymorphisms influence histologic progression of HCV in patients with PNALT.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Falleti E,Fabris C,Vandelli C,Colletta C,Cussigh A,Smirne C,Fontanini E,Cmet S,Minisini R,Bitetto D,Toniutto P,Pirisi M

doi

10.1016/j.humimm.2010.06.006

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

999-1004

issue

10

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(10)00149-7

journal_volume

71

pub_type

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