Interferon-gamma response region in the promoter of the class II MHC gene, DPA.

abstract：:The C-type lectins DC-SIGN and L-SIGN are important pathogen-recognition receptors of the human innate immune system. Both lectins have been shown to interact with a vast range of infectious agents, including Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. In addition, DC-SIGN and L-SIGN pos...

journal_title：Human immunology

authors： Barreiro LB,Neyrolles O,Babb CL,van Helden PD,Gicquel B,Hoal EG,Quintana-Murci L

更新日期：2007-02-01 00:00:00

abstract：:Conclusions from association studies could be spurious because of population stratification; therefore we combined association with family studies seeking to confirm which human leukocyte antigen (HLA) class II alleles/haplotypes were associated with type 1 diabetes (T1D) in the admixed Latin America. By calculating t...

journal_title：Human immunology

authors： Cifuentes RA,Rojas-Villarraga A,Anaya JM

更新日期：2011-07-01 00:00:00

abstract：:A flow cytometric method of simultaneously screening both HLA Class I and Class II panel reactive antibodies (PRA) was developed using a pool of 30 different Class I and 30 different Class II microbeads coated with purified HLA antigens. The antibodies in the serum that react specifically to the coated HLA antigens ar...

journal_title：Human immunology

authors： Pei R,Wang G,Tarsitani C,Rojo S,Chen T,Takemura S,Liu A,Lee J

更新日期：1998-05-01 00:00:00

abstract：:Uninfected, as well as feline leukemia virus (FeLV) infected human cells cultured under high cell density conditions undergo changes in the expression of major histocompatibility complex (MHC) antigens, as determined by indirect trace binding radio immunoassay (RIA) using monoclonal anti-HLA antibodies and by decrease...

journal_title：Human immunology

authors： Azocar J,Essex M,Yunis EJ

更新日期：1983-06-01 00:00:00

abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...

journal_title：Human immunology

authors： Deulofeut H,Wilderson JL,Barron KS,Robinson MA

更新日期：1995-07-01 00:00:00

abstract：:Signal transducer and activator of transcription 4 (STAT4) has been recently identified as a susceptibility gene for multiple autoimmune diseases. Here we performed a comprehensive analysis of the association between STAT4 and several different autoimmune disorders to identify potential common inflammatory principles ...

journal_title：Human immunology

authors： Zheng J,Yin J,Huang R,Petersen F,Yu X

更新日期：2013-08-01 00:00:00

abstract：:In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxi...

journal_title：Human immunology

authors： Miceli MC,Barry TS,Finn OJ

更新日期：1988-07-01 00:00:00

abstract：:The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regio...

journal_title：Human immunology

authors： Traks T,Karelson M,Reimann E,Rätsep R,Silm H,Vasar E,Kõks S,Kingo K

更新日期：2016-05-01 00:00:00

abstract：:Shellfish allergy affects approximately 2% of the population and can cause immediate hypersensitivity reactions such as urticaria, swelling, difficulty breathing, and, in some cases, anaphylaxis. Tropomyosin is the major shrimp allergen and binds IgE in two-thirds of patients. A total of 38 shrimp-allergic patients an...

journal_title：Human immunology

authors： Wang S,Delgado JC,Ravkov E,Eckels DD,Georgelas A,Pavlov IY,Cusick M,Sebastian K,Gleich GJ,Wagner LA

更新日期：2012-04-01 00:00:00

abstract：:In this paper we briefly review three common immunological misconceptions that feature prominently among anti-vaccinationists, and in turn, fuel patient and parental concerns, questions, and fears about vaccines. In particular, this Perspective covers a brief history of the anti-vaccine movement, and three common fals...

journal_title：Human immunology

authors： Poland GA,Jacobson RM

更新日期：2012-08-01 00:00:00

abstract：:Interactions between human IgG with human FcgammaRI and FcgammaRIIa (R131) were studied to investigate the role of the hinge region of IgG3 and IgG1 in the binding of the antibodies to FcgammaR. It was found that a hinge deletion mutant of IgG3 (IgG3 m15) was reduced in its ability to bind to FcgammaRI and FcgammaRIIa...

journal_title：Human immunology

authors： Redpath S,Michaelsen TE,Sandlie I,Clark MR

更新日期：1998-11-01 00:00:00

abstract：:The number of units and especially the number of different HLA haplotypes present in a cord blood (CB) bank is a crucial determinant of its usefulness. We generated data relevant to the development of our national CB in Finland. The HLA haplotype distribution was examined between specific populations. We developed gra...

journal_title：Human immunology

authors： Haimila K,Penttilä A,Arvola A,Auvinen MK,Korhonen M

更新日期：2013-02-01 00:00:00

abstract：:Beta 2m serum levels have been shown to be increased in patients with tuberculosis and HIV infection. We determined the stability of beta 2m and of sHLA-I dimers in serum, and then determined the levels of both molecules in 60 non-HIV-infected patients with active pulmonary tuberculosis and in 55 adult controls. The l...

journal_title：Human immunology

authors： Inostroza J,Muñoz P,Espinoza R,Millaqueo L,Diaz P,Leiva L,Sorensen R

更新日期：1994-07-01 00:00:00

abstract：:Monoclonal antibodies (DA-2 and CA-2) and xenoantisera (rabbit anti-human, p23,30) specific for HLA-DR framework determinants were added to primary and secondary mixed lymphocyte cultures. Although such antisera were shown to inhibit primary MLC, primed lymphocytes were much less sensitive to the blocking effects of t...

journal_title：Human immunology

authors： Eckels DD,Woody JN,Hartzman RJ

更新日期：1981-10-01 00:00:00

abstract：:Soluble human leukocyte antigen-G molecules (HLA-G5) can be found in the peripheral blood of healthy females and males, and in other body fluids. To identify cells secreting HLA-G5 we generated a rabbit antiserum against a peptide motif encoded by intron-4 of HLA-G (RaHLA-G/I-4). Utilizing this antiserum as capture an...

journal_title：Human immunology

authors： Rebmann V,Busemann A,Lindemann M,Grosse-Wilde H

更新日期：2003-11-01 00:00:00

abstract：:Attempts to predict outcome of bone marrow transplantation based on killer immunoglobulin-like receptor (KIR) and HLA genotyping have yielded discordant results. To better understand the factors involved, we investigated natural killer (NK) cell function and correlated it with genetics and expression of inhibitory KIR...

journal_title：Human immunology

authors： Han M,Fallena M,Guo Y,Stastny P

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...

journal_title：Human immunology

authors： Shehjar F,Afroze D,Misgar RA,Malik SA,Laway BA

更新日期：2018-04-01 00:00:00

abstract：:The multidrug resistance gene (mdr1) is a member of the recently described ATP binding cassette (ABC) superfamily of transporters. Family members include: (1) the cystic fibrosis transmembrane conductance regulator gene; (2) the hlyB gene of bacteria, and (3) the histocompatibility antigen modifier (HAM) gene. The lev...

journal_title：Human immunology

authors： Coon JS,Wang YZ,Bines SD,Markham PN,Chong AS,Gebel HM

更新日期：1991-10-01 00:00:00

abstract：:The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...

journal_title：Human immunology

authors： Demaria S,Bushkin Y

更新日期：2000-12-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients comprise at least 20% of treated patients and are at high risk for coronary artery abnormalities. If identified early in the course of the disease, such patients may benefit from additional anti-inflammatory therapy. The aim of this study was t...

journal_title：Human immunology

authors： Fury W,Tremoulet AH,Watson VE,Best BM,Shimizu C,Hamilton J,Kanegaye JT,Wei Y,Kao C,Mellis S,Lin C,Burns JC

更新日期：2010-09-01 00:00:00

abstract：:Two groups of residents in an endemic area of Leishmania major infection in Iran with positive leishmanin skin tests who were either asymptomatic or had healed cutaneous leishmaniasis lesions were compared with respect to their T helper responses. The percentages of regulatory T cells (Treg; CD4(+)CD25(high) FoxP3(+))...

journal_title：Human immunology

authors： Bahrami F,Darabi H,Riazi-Rad F,Khaze V,Ajdary S,Alimohammadian MH

更新日期：2014-10-01 00:00:00

abstract：:Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...

journal_title：Human immunology

authors： Lee N,Shin MS,Kang Y,Park K,Maeda T,Nishioka H,Fujii H,Kang I

更新日期：2016-06-01 00:00:00

abstract：:The polymorphic MICA gene encodes glycoproteins that activate T cells and NK cells through the NKG2D receptor and may costimulate immune functions. We found that MICA was expressed on freshly isolated human fibroblasts and was markedly decreased when fibroblasts were grown to confluency in culture dishes. MICA surface...

journal_title：Human immunology

authors： Zou Y,Mirbaha F,Stastny P

更新日期：2006-03-01 00:00:00

abstract：:We describe the production of mouse monoclonal antibodies specific for the human TcR using as the immunogen transfected murine T-cell hybridoma cells coexpressing mouse CD3 with human Jurkat TcR alpha and beta chains. The shortage of monoclonal antibodies (mAbs) specific for the human TcR-V alpha and V beta families r...

journal_title：Human immunology

authors： Zumla A,McCormack A,George A,Batchelor R,Lechler R

更新日期：1992-11-01 00:00:00

abstract：UNLABELLED:Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to evaluate t...

journal_title：Human immunology

authors： Oweira H,Lahdou I,Daniel V,Opelz G,Schmidt J,Zidan A,Mehrabi A,Sadeghi M

更新日期：2016-10-01 00:00:00

abstract：:Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...

journal_title：Human immunology

authors： Lucotte G,Gérard N,Mercier G

更新日期：2001-09-01 00:00:00

abstract：:Mannose-binding lectin (MBL) role in the carriage of oropharyngeal bacteria is not known. We investigated the association of smoking, MBL2 polymorphisms, and MBL concentrations with oropharyngeal carriage of respiratory bacteria in young men. Oropharyngeal specimens, MBL concentrations, and MBL2 gene polymorphisms wer...

journal_title：Human immunology

authors： Jounio U,Rantala A,Bloigu A,Juvonen R,Lajunen T,Silvennoinen-Kassinen S,Peitso A,Vainio O,Harju T,Saukkoriipi A,Leinonen M

更新日期：2010-03-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a major, soluble, pattern-recognition molecule and an important component of the innate host defense. The role of MBL in inflammatory bowel diseases (IBDs) is controversial. We determined the prevalence of MBL deficiency in a Hungarian IBD patients' cohort, and whether it is associated ...

journal_title：Human immunology

authors： Papp M,Lakatos PL,Harsfalvi J,Farkas G,Palatka K,Udvardy M,Molnar T,Farkas K,Nagy F,Veres G,Lakatos L,Kovacs A,Dinya T,Kocsis AK,Papp J,Hungarian IBD Study Group.,Altorjay I

更新日期：2010-04-01 00:00:00

abstract：:The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

journal_title：Human immunology

authors： Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

更新日期：1989-05-01 00:00:00

abstract：:It has been known for 40 years that cytotoxic human leukocyte antigen (HLA) antibodies are associated with graft rejection. However, the complement-dependent cytotoxicity assay (CDC) used to define these clinically deleterious antibodies suffers from a lack of sensitivity and specificity. Recently, methods exploiting ...

journal_title：Human immunology

authors： Chen G,Sequeira F,Tyan DB

更新日期：2011-10-01 00:00:00