Abstract:
:The goal of this study was to evaluate the influence of KIR-HLA genotypes on the outcome of patients undergoing treatment for haematological malignancies by non-T-depleted lymphocyte haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. The prospective study was conducted at the Center of Hematology, University of Campinas, and 50 patients and their donors were followed up from 2008 to 2014. KIR and HLA class I genes were genotyped and patients grouped based on the presence of KIR ligands combined with KIR genotype of their respective donors. Patients with all KIR ligands present (n=13) had a significantly higher (p=0.04) incidence of acute graft-versus-host-disease (GVHD) than patients with one or more KIR ligands missing (n=37). The overall survival following transplantation of patients with myeloid malignancies (n=27) was significantly higher (p=0.035) in the group with one or more KIR ligands missing (n=18) than in the group with all ligands present (n=9). Presence of KIR2DS2 was associated with a worsening of HSCT outcome while reactivation of cytomegalovirus (CMV) infection improved the outcome of patients with one or more KIR ligands missing. Our results indicate that KIR-HLA interactions affect the outcome of the HLA-matched transplantation, particularly in patients with myeloid malignancies.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Cardozo DM,Marangon AV,da Silva RF,Aranha FJP,Visentainer JEL,Bonon SHA,Costa SCB,Miranda ECM,de Souza CA,Guimarães Fdoi
10.1016/j.humimm.2016.07.003subject
Has Abstractpub_date
2016-10-01 00:00:00pages
861-868issue
10eissn
0198-8859issn
1879-1166pii
S0198-8859(16)30156-2journal_volume
77pub_type
杂志文章相关文献
HUMAN IMMUNOLOGY文献大全abstract::The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.003
更新日期:2018-03-01 00:00:00
abstract::The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(94)90008-6
更新日期:1994-10-01 00:00:00
abstract::The human leukocyte antigen (HLA) genes are highly variable and are known to play an important role in disease outcomes, including infectious diseases. Prior knowledge of HLA polymorphisms in a population usually forms the basis for an effective case-control study design. As a prelude to future disease association ana...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.09.005
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.05.002
更新日期:2018-08-01 00:00:00
abstract::Mucin 1 is a cell-membrane associated mucin, expressed on epithelial and immune cells that helps protect against pathogenic infections. In humans, MUC1 is highly polymorphic, predominantly due to the presence of a variable number tandem repeat (VNTR) region in the extracellular domain that results in MUC1 molecules of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.06.001
更新日期:2019-10-01 00:00:00
abstract::Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/s0198-8859(99)00151-2
更新日期:2000-02-01 00:00:00
abstract::The cellular basis of graft rejection and the development of strategies for specific suppression of T cell responses against allogeneic and xenogeneic transplants represents an area of active investigation. Recently, a population of MHC-class I restricted CD8+CD28- T suppressor cells (Ts) which are able to inhibit spe...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(98)00134-7
更新日期:1999-04-01 00:00:00
abstract::Mononuclear cells obtained from a child at the acute presentation of type I diabetes were stimulated in vitro with human insulin followed by IL-2 and IL-4. All of the T-cell clones isolated from this stimulation were autoreactive, recognizing autologous B cells in the absence of insulin or other exogenous antigens. El...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(93)90128-n
更新日期:1993-04-01 00:00:00
abstract::Toll-like receptors (TLRs) are important in the initiation of immune responses in both health and disease. How TLR activity alters with age, gender, and also with immunosuppressive agents is still largely unexplored. We studied TLR activity in 49 healthy individuals as well as in 26 patients receiving immunosuppressiv...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2010.01.018
更新日期:2010-04-01 00:00:00
abstract::Genes encoding for prolactin (PRL) and its receptor (PRLR) are possible candidates for multiple sclerosis (MS) and systemic lupus erythematosus (SLE) susceptibility. In fact: (1) a prolactin secretion dysfunction has been described in several autoimmune diseases including SLE and MS and their animal models; (2) both P...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(02)00804-2
更新日期:2003-02-01 00:00:00
abstract::Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.03.010
更新日期:2017-01-01 00:00:00
abstract::The polymorphic MICA gene encodes glycoproteins that activate T cells and NK cells through the NKG2D receptor and may costimulate immune functions. We found that MICA was expressed on freshly isolated human fibroblasts and was markedly decreased when fibroblasts were grown to confluency in culture dishes. MICA surface...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2006.02.018
更新日期:2006-03-01 00:00:00
abstract:UNLABELLED:Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to evaluate t...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.234
更新日期:2016-10-01 00:00:00
abstract::A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of t...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2004.02.012
更新日期:2004-05-01 00:00:00
abstract::Serological identification of a new HLA-Bw16 subtype, B39B, was made by the analysis of reaction patterns of many alloantisera and one monoclonal antibody. The B39B pattern of reactivity was shown to be distinct from HLA-Bw38, Bw39, and 8w57. Cytotoxicity testing before and after absorption suggests that the B39B spec...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90059-x
更新日期:1985-09-01 00:00:00
abstract::The presence of extra HLA antigens has been demonstrated, serologically and biochemically, on the surface of lymphoblasts from a patient with acute lymphoblastic leukemia of the T-cell subtype (T-ALL). Family analysis of this patient revealed the presence of the expected antigens, plus an additional HLA antigen (A24) ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(85)90331-3
更新日期:1985-03-01 00:00:00
abstract::Rapamycin contributes to the expansion of regulatory T cells (Tregs) in vitro. We investigated CD4(+)CD25(high)CD127(low) Treg level dynamics as well as the major parameters of cell immunity and sCD25 and highly sensitive C-reactive protein (hsCRP) concentrations in the blood of patients after coronary stenting (CS) w...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2011.03.015
更新日期:2011-07-01 00:00:00
abstract::"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...
journal_title:Human immunology
pub_type: 历史文章,杂志文章
doi:10.1016/j.humimm.2016.08.008
更新日期:2017-01-01 00:00:00
abstract::The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 h...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(90)90100-4
更新日期:1990-05-01 00:00:00
abstract::We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent ha...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.07.286
更新日期:2020-09-01 00:00:00
abstract::A total of 155 Nicaraguan Mestizos from across the country were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2019.05.004
更新日期:2019-07-01 00:00:00
abstract::A reliable method for high-resolution HLA-DQB1 typing using a combination of PCR- restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism (SSCP) analysis is described. The second exon of the DQB1 gene was subjected to PCR using generic primers and digested with two restriction e...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(99)00069-5
更新日期:1999-09-01 00:00:00
abstract::Polymorphic Alu insertions from the MHC class I region were analyzed in 215 autochthonous Basques from Guipuzcoa and Navarre provinces, with the aim of contributing new MHC Alu data in European ancestry populations. We also seek to assess both the genetic position of native Basques among worldwide samples and the effi...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2012.04.010
更新日期:2012-07-01 00:00:00
abstract::The aim of this work was to investigate the longitudinal evolution of plasmatic soluble HLA-G (sHLA-G: shed HLA-G1 plus HLA-G5) during pregnancy, and if peripheral maternal antigen presenting cells (APC) can be a source of sHLA-G. Blood samples were obtained from 45 volunteers during normal pregnancy, 8 of them monthl...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2007.04.007
更新日期:2007-08-01 00:00:00
abstract::The association of Ig allotypes with celiac disease was analyzed in a sample of 95 Italian patients typed for HLA polymorphisms. No significant association was found for any Gm, A2m, or Km specificity when the overall sample was considered. However, significant different sex ratios were shown by patients' fnb positive...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(83)90065-4
更新日期:1983-02-01 00:00:00
abstract::The complement system (CS) is a key element of immunity against pathogens but also seems to influence other events, such as tumorigenesis and tissue repair. Complement component 7 (C7) is a key component of the lytic pathway of CS, leading to the formation of the membrane attack complex (MAC). This study aimed to inve...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.06.009
更新日期:2018-09-01 00:00:00
abstract::In humans, the in vitro antibody response directed towards mannan, a polysaccharide extracted from the cell wall of Candida albicans, has been previously shown to be dependent on the presence of T lymphocytes and monocytes. Evidence is now given for the existence of a genetic restriction governing this response since ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/0198-8859(86)90040-6
更新日期:1986-05-01 00:00:00
abstract::T cell mediated immunity is known to play a central role in the host response to control intra-cellular pathogens. This work demonstrates the presence of specific CD4(+) T cells to Leishmania spp. antigens in peripheral mononuclear cells of naïve individuals (normal volunteers from non-endemic regions). The responder ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/s0198-8859(00)00119-1
更新日期:2000-06-01 00:00:00
abstract::This study addresses the reactivity patterns of human cytotoxic HLA class I epitope-specific monoclonal antibodies in Ig-binding and complement component C1q-binding Luminex assays in comparison with complement-dependent lymphocytotoxicity data reported at the 13th International HLA Workshop. Some monoclonal antibodie...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2013.05.016
更新日期:2013-10-01 00:00:00
abstract::Human leukocyte antigen-G (HLA-G) is a nonclassical tolerogenic molecule that can be expressed either as membrane bound (HLA-G1) or secreted (HLA-G5) isoforms. Upregulation of HLA-G1 or HLA-G5 expression by tumor cells constitutes an efficient way to escape from antitumoral immune responses. The inhibitory role of HLA...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2009.07.019
更新日期:2009-12-01 00:00:00