当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > Full-length next-generation sequencing of HLA class I and II genes in a cohort from Thailand.

Full-length next-generation sequencing of HLA class I and II genes in a cohort from Thailand.

Abstract：

:The human leukocyte antigen (HLA) genes are highly variable and are known to play an important role in disease outcomes, including infectious diseases. Prior knowledge of HLA polymorphisms in a population usually forms the basis for an effective case-control study design. As a prelude to future disease association analyses, we report HLA class I and II diversity in 334 unrelated donors from a Dengue vaccine efficacy trial conducted in Thailand. Long-range PCR amplification of six HLA loci was performed on DNA extracted from saliva samples. HLA-A, -B, -C, -DPB1, -DQB1 and -DRB1 were genotyped using a next-generation sequencing method presented at the 17th International HLA and Immunogenetics Workshop. In total, we identified 201 HLA alleles, including 35 HLA-A, 57 HLA-B, 28 HLA-C, 24 HLA-DPB1, 21 HLA-DQB1 and 36 HLA-DRB1 alleles. Very common HLA alleles with frequencies greater than 10 percent were A∗11:01:01, A∗33:03:01, A∗24:02:01, B∗46:01:01, C∗07:02:01, C∗01:02:01, C∗08:01:01, DPB1∗05:01:01, DPB1∗13:01:01, DPB1∗04:01:01, DPB1∗02:01:02, DQB1∗03:01:01, DQB1∗05:02:01, DQB1∗03:03:02, DRB1∗12:02:01, DRB1∗09:01:02, and DRB1∗15:02:01. A novel HLA allele, B∗15:450, had a non-synonymous substitution and occurred in more than one donor. Population-based full-length NGS HLA typing is more conclusive and provides a sound foundation for exploring disease association in a given population.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Geretz A,Ehrenberg PK,Bouckenooghe A,Fernández Viña MA,Michael NL,Chansinghakule D,Limkittikul K,Thomas R

doi

10.1016/j.humimm.2018.09.005

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

773-780

issue

11

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(18)30860-7

journal_volume

79

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Characterization of a monoclonal anti-Bw4 antibody (Tü109): evidence for similar epitopes on the Bw4 and Bw6 antigens.

    abstract：:The production and serologic, as well as immunochemical properties of a cytotoxic murine IgG monoclonal antibody (Tü109) that precipitates HLA-class I molecules, are described. In the microcytotoxicity assay Tü109 supernatant was demonstrated on a panel of 424 HLA-ABC, -DR, -DQ, -MT typed normal Caucasian blood donors...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(85)90241-1

    authors： Müller C,Herbst H,Uchanska-Ziegler B,Ziegler A,Schunter F,Steiert I,Muller C,Wernet P

    更新日期：1985-12-01 00:00:00

  • Genetic evaluation of the TNF-α -238G>A and -308G>A promoter polymorphisms in Croatian patients with type I diabetes.

    abstract：:A case-control study was performed to establish a potential association of two TNF-α gene promoter SNPs (-238G>A and -308G>A) with occurrence of type 1 Diabetes mellitus (T1DM) in Croatian population (174 patients and 193 healthy controls). Genotypes (obtained by polymerase chain reaction-restriction fragment length p...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.09.003

    authors： Korolija M,Hadžija M,Medvidović EP,Pavkovic P,Kapitanović S,Renar IP,Hadžija MP

    更新日期：2010-12-01 00:00:00

  • Soluble HLA proteins with bound peptides are released from the cell surface by the membrane metalloproteinase.

    abstract：:The metalloproteinase (MPase)-mediated pathway of MHC class I processing is a distinct cellular mechanism that generates soluble HLA proteins. It has been implicated in modulation of immune responses induced during transplantation events. It is, therefore, important to define the characteristics of soluble HLA species...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00213-5

    authors： Demaria S,Bushkin Y

    更新日期：2000-12-01 00:00:00

  • Refined information on alleles belonging to the C*07:01/07:06/07:18 group in the Korean population.

    abstract：:Alleles of the C*07:01/07:06/07:18 group is distinguished by polymorphisms in exons 5-6. In a previous study, we focused on exons 2-3 of the gene and showed that 6.8% of Koreans express alleles in this group. In this study, we identified allelic and haplotypic diversities of the C*07:01/07:06/07:18 group in Koreans. A...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2011.05.002

    authors： Lee KW,Jung YA

    更新日期：2011-09-01 00:00:00

  • The detection of human minor alloantigens following restriction determinant implantation.

    abstract：:The recognition of minor alloantigens by cytotoxic T lymphocytes (CTL) serves as a model for the recognition of tumor and viral antigens. Progress in this area has been limited, however, since CTL recognize minor alloantigens only in association with self-class I antigens. Thus, experiments designed to study minor all...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90035-8

    authors： Zier KS,Volsky DJ,Sinangil F

    更新日期：1987-05-01 00:00:00

  • NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells.

    abstract：:The chemokine C receptor 7 (CCR7) is a G-protein-coupled heptahelical receptor (GPCR) that is expressed on a wide variety of cells including memory T cells, B cells, mature dendritic cells, and cancer cells. Activated by its ligands CCL19 or CCL21, CCR7 plays a major role in metastasis of cancer cells. Recent studies ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2015.03.010

    authors： Al Akoum C,Akl I,Rouas R,Fayyad-Kazan M,Falha L,Renno T,Burny A,Lewalle P,Fayyad-Kazan H,Badran B

    更新日期：2015-05-01 00:00:00

  • Heightened expression of HLA-DQB1 and HLA-DQB2 in pre-implantation biopsies predicts poor late kidney graft function.

    abstract：BACKGROUND:Accurate pre-transplant prediction of late graft function remains an unmet need in kidney transplantation. The aim of this study was to evaluate HLA genes expression levels in pre-implantation biopsies (PIB) of deceased donor kidneys as markers for long-term graft outcome. METHODS:HLA genes expression analy...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.05.002

    authors： Mine KL,Tedesco-Silva H,Mourão TB,Campos EF,Salzedas LA,Aguiar B,Felipe CR,Medina-Pestana JO,Gerbase-DeLima M

    更新日期：2018-08-01 00:00:00

  • FOXP3 expression and frequency of regulatory T cells in healed individuals from Leishmania major infection and the asymptomatic cases.

    abstract：:Two groups of residents in an endemic area of Leishmania major infection in Iran with positive leishmanin skin tests who were either asymptomatic or had healed cutaneous leishmaniasis lesions were compared with respect to their T helper responses. The percentages of regulatory T cells (Treg; CD4(+)CD25(high) FoxP3(+))...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2014.08.204

    authors： Bahrami F,Darabi H,Riazi-Rad F,Khaze V,Ajdary S,Alimohammadian MH

    更新日期：2014-10-01 00:00:00

  • Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.

    abstract：:NKG2D is an important activating receptor on NK cells and T-cells and has a diverse panel of ligands (NKG2DL) which include the ULBP and RAET1 proteins. Several NKG2DL exhibit a considerable degree of genetic polymorphism, and although the functional significance of such allelic variation remains unclear, genetic vari...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.02.018

    authors： Antoun A,Jobson S,Cook M,O'Callaghan CA,Moss P,Briggs DC

    更新日期：2010-06-01 00:00:00

  • Association of rs12979860 and rs8099917 polymorphisms near IL28B with SVR in hepatic allograft recipients with HCV recurrence undergoing PEG-IFN/RBV therapy: a meta-analysis.

    abstract：:The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We ...

    journal_title：Human immunology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.humimm.2014.09.005

    authors： Zhang L,Lu Q,Yang Z,Wang X,Cai L,Liu X,Liao R,Yang X,Chen Y,Yang Z

    更新日期：2014-12-01 00:00:00

  • MHC class I and class II phenotype, gene, and haplotype frequencies in Greeks using molecular typing data.

    abstract：:In the present study, DNA typing for HLA-A, C, B, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 was performed for 246 healthy, unrelated Greek volunteers of 20-59 years of age. Phenotype, genotype frequencies, Hardy-Weinberg equilibrium fit, and 3-locus haplotype frequencies for HLA-A, C, B, HLA-A, B, DRB1, HLA-DRB1, D...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00115-4

    authors： Papassavas EC,Spyropoulou-Vlachou M,Papassavas AC,Schipper RF,Doxiadis IN,Stavropoulos-Giokas C

    更新日期：2000-06-01 00:00:00

  • Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain.

    abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2003.12.014

    authors： Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

    更新日期：2004-04-01 00:00:00

  • Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma.

    abstract：:Interleukin-8 (IL-8), a potent chemoattractant, has been demonstrated to contribute to human cancer progression through its potential functions as a mitogenic, angiogenic, and motogenic factor. We designed a broad study to investigate whether genetic variation in IL-8 has implications for susceptibility to and prognos...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.03.018

    authors： Snoussi K,Mahfoudh W,Bouaouina N,Ahmed SB,Helal AN,Chouchane L

    更新日期：2006-01-01 00:00:00

  • Large-scale preparation of human anti-third-party veto cytotoxic T lymphocytes depleted of graft-versus-host reactivity: a new source for graft facilitating cells in bone marrow transplantation.

    abstract：:Induction of donor type chimerism in mildly prepared hosts without graft-versus-host disease (GvHD) is a most desirable goal in bone morrow transplantation. We have recently demonstrated in a mouse model that donor veto cytotoxic T lymphocytes (CTLs) can facilitate the induction of donor type chimerism in sublethally ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2005.03.004

    authors： Aviner S,Yao X,Krauthgamer R,Gan Y,Goren-Arbel R,Klein T,Tabilio A,McMannis JD,Champlin R,Martelli MF,Bachar-Lustig E,Reisner Y

    更新日期：2005-06-01 00:00:00

  • Independence of measles-specific humoral and cellular immune responses to vaccination.

    abstract：:With a larger, independent cohort and more sophisticated measures, we sought to confirm our work that indicated independence of humoral and cellular immunity following measles vaccination. We recruited an age-stratified random cohort of 764 healthy subjects from all socioeconomic strata, all with medical-record docume...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.02.016

    authors： Jacobson RM,Ovsyannikova IG,Vierkant RA,Pankratz VS,Poland GA

    更新日期：2012-05-01 00:00:00

  • Influence of HLA class I and class II antigens on the peripheral T-cell receptor repertoire.

    abstract：:Using TCR-specific mAbs, we analyzed the TCR distribution in the CD4 and CD8 compartments of peripheral blood T cells from members of six families, including two which were informative for an HLA-B/DR crossover. TCR distribution in the CD4 compartment is influenced by MHC class II antigens as it was similar in the chi...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)90055-8

    authors： Reed EF,Tugulea SL,Suciu-Foca N

    更新日期：1994-06-01 00:00:00

  • Clonal diversity of the T-cell population responding to a dominant HLA-A2 epitope of HER-2/neu after active immunization in an ovarian cancer patient.

    abstract：:Natural antigen processing and presentation of antigen is thought to be important for the generation of a broad functional repertoire of antigen-specific T cells. In this study, the T-cell repertoire to an immunodominant human leukocyte antigen A2 (HLA-A2) binding peptide epitope of HER-2/neu, p369-377, was examined i...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(02)00401-9

    authors： Knutson KL,Disis ML

    更新日期：2002-07-01 00:00:00

  • HLA class II restriction repertoire of antigen-specific T cells. I. The main restriction determinants for antigen presentation are associated with HLA-D/DR and not with DP and DQ.

    abstract：:In order to study the HLA class II restriction repertoire in antigen presentation to T cells, T lymphoblasts (T-LB) of ten different HLA class II donors were generated by a simple and rapid technique; peripheral blood lymphocytes (PBL) were restimulated in vitro with purified protein derivative (PPD) or tetanus toxoid...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(85)90017-5

    authors： Ottenhoff TH,Elferink DG,Hermans J,de Vries RR

    更新日期：1985-06-01 00:00:00

  • Genetic diversity of HLA system in four populations from Baja California, Mexico: Mexicali, La Paz, Tijuana and rural Baja California.

    abstract：:We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 250 Mexicans from the states of Baja California Norte and Baja California Sur living in Mexicali (N = 100), La Paz (N = 75), Tijuana (N = 25) and rural communities (N = 50) to obtain information regarding allelic and h...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2019.06.007

    authors： Escobedo-Ruíz A,Barquera R,González-Martín A,Argüelles-San Millán JM,Uribe-Duarte MG,Hernández-Zaragoza DI,Clayton S,Arrieta-Bolaños E,Ruíz-Corral MJ,Goné-Vázquez I,Arellano-Prado FP,Martínez-Álvarez JC,García-Arias VE,Rodrígue

    更新日期：2020-09-01 00:00:00

  • Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide stimulation.

    abstract：:Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2017.03.010

    authors： Venet F,Schilling J,Cazalis MA,Demaret J,Poujol F,Girardot T,Rouget C,Pachot A,Lepape A,Friggeri A,Rimmelé T,Monneret G,Textoris J

    更新日期：2017-01-01 00:00:00

  • Interleukin-6 gene variants and the risk of sepsis development in children.

    abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.06.003

    authors： Michalek J,Svetlikova P,Fedora M,Klimovic M,Klapacova L,Bartosova D,Hrstkova H,Hubacek JA

    更新日期：2007-09-01 00:00:00

  • Serological, functional, and immunochemical characterization of a monoclonal antibody (MoAb Q2/70) to human Ia-like antigens.

    abstract：:Serological and immunochemical studies showed that monoclonal antibody Q2/70 (MoAb Q2/70), produced by the hybridoma technique, is specific for human Ia-like antigens. This antibody recognizes an antigenic determinant which is different from those defining the serologic polymorphism of Ia-like antigens, and is express...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(80)90016-6

    authors： Quaranta V,Indiveri F,Glassy MC,Ng A,Russo C,Molinaro GA,Pellegrino MA,Ferrone S

    更新日期：1980-10-01 00:00:00

  • Anti-HLA-B7,B27,Bw42,Bw54,Bw55,Bw56, Bw67,Bw73 monoclonal antibodies: specificity, idiotypes, and application for a double determinant immunoassay.

    abstract：:The monoclonal antibodies (MoAbs) KS3 and KS4 are secreted by hybridomas constructed with splenocytes from a BALB/c mouse sequentially immunized with the cultured lymphoid cells JKu and LG-2 which share only the HLA-B27 specificity. Serologic and immunochemical assays have shown that the two MoAbs recognize the same (...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(88)90071-7

    authors： Sakaguchi K,Ono R,Tsujisaki M,Richiardi P,Carbonara A,Park MS,Tonai R,Terasaki PI,Ferrone S

    更新日期：1988-03-01 00:00:00

  • Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children.

    abstract：:The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percent...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(99)00090-7

    authors： Elliott SR,Macardle PJ,Roberton DM,Zola H

    更新日期：1999-11-01 00:00:00

  • Tolerance: a case of self/not-self discrimination maintained by clonal deletion?

    abstract：:The clonal selection theory of immune reactivity is based on a metaphor of self/not-self discrimination and considers self-tolerance to result from clonal deletion. There is evidence that a deletional mechanism is responsible for negative selection of self MHC-reactive T-cells in the thymus. Bretscher/Cohn theory buil...

    journal_title：Human immunology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/S0198-8859(96)00294-7

    authors： Lafferty KJ,Gazda LS

    更新日期：1997-02-01 00:00:00

  • Propagation of infiltrating lymphocytes and graft coronary disease in cardiac transplant recipients.

    abstract：:The pattern of lymphocyte growth from endomyocardial biopsies in 55 heart transplant recipients was shown to be correlated with the subsequent development of graft coronary disease. Persistent lymphocyte growth was observed in 39 patients, and 15 of these growers (or 41%) developed graft coronary disease. In contrast,...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90023-i

    authors： Kaufman CL,Zeevi A,Kormos RL,Zerbe TR,Keenan RJ,Uretsky BF,Griffith BP,Hardesty RL,Duquesnoy RJ

    更新日期：1990-06-01 00:00:00

  • Anti-CD4 monoclonal antibody effects cellular hyporesponsiveness and prolongs renal allograft survival in the rat.

    abstract：:LEW strain rats received BN strain renal allografts and were treated with daily injections of 100 micrograms BWH-4, a new IgG2a mouse anti-rat CD4 monoclonal antibody, intravenously for 5 to 10 days. These animals had a median actuarial survival of 28 days. Control animals rejected their grafts and died of uremia betw...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90098-0

    authors： Sayegh MH,Kut JP,Milford EL

    更新日期：1989-10-01 00:00:00

  • Assignment of HLA-DPB alleles by computerized matching based upon sequence data.

    abstract：:Routine HLA typing by serology has been supported by DNA or protein analysis of the respective molecules in cases when serologic typing was inconclusive or difficult to perform. DNA analysis by RFLP, SSO, or PCR amplification with SSP is a reliable tool for the identification of alleles. Because DNA sequences may now ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(93)90503-s

    authors： Rozemuller EH,Bouwens AG,Bast BE,Tilanus MG

    更新日期：1993-08-01 00:00:00

  • Immune phenotype predicts new onset diabetes after kidney transplantation.

    abstract：:Few data are available concerning immune factors involved in the occurrence of new onset diabetes after transplantation (NODAT). Our objective was to determine an immune profile associated with the subsequent development of NODAT. The secondary objective was to build a predictive model of NODAT. We studied a prospecti...

    journal_title：Human immunology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.humimm.2019.08.006

    authors： Ducloux D,Courivaud C,Bamoulid J,Crepin T,Gaiffe E,Laheurte C,Vauchy C,Rebibou JM,Saas P,Borot S

    更新日期：2019-11-01 00:00:00

  • IL12B, IL23A, IL23R and HLA-C*06 genetic variants in psoriasis susceptibility and response to treatment.

    abstract：:The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 5...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.02.003

    authors： Bojko A,Ostasz R,Białecka M,Klimowicz A,Malinowski D,Budawski R,Bojko P,Droździk M,Kurzawski M

    更新日期：2018-04-01 00:00:00