当前位置： SCI文献检索 > HUMAN IMMUNOLOGY期刊下所有文献 > IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells.

IL-1β induces expression of costimulatory molecules and cytokines but not immune feedback regulators in dendritic cells.

Abstract：

:Dendritic cells play an important role in the initiation of immune reactions. Due to their high capacity to prime T-cell responses, the activation of dendritic cells must be tightly controlled. Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate human dendritic cells and induce immune-regulatory molecules versus the effects induced by pathogen-derived stimuli. Upon activation with either IL-1β or microbial stimuli, monocyte-derived dendritic cells showed enhanced expression of costimulatory molecules, increased secretion of chemokines and cytokines, and the ability to activate T cells. In contrast, immune-feedback molecules, including PD-L1, IL-1RA, IL-10 and SOCS1, were exclusively upregulated in response to microbial stimuli, whereas IL-1β treatment had no inducing effect on them. Thus, the limited capacity of IL-1β to induce potential feedback inhibitors may support its key etiologic role in chronic inflammation and autoinflammatory responses.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Michelini S,Sarajlic M,Duschl A,Horejs-Hoeck J

doi

10.1016/j.humimm.2018.06.002

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

610-615

issue

8

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(18)30175-7

journal_volume

79

pub_type

杂志文章

相关文献

HUMAN IMMUNOLOGY文献大全
  • Association of polymorphic variants of IL-1β and IL-1RN genes in the development of Graves' disease in Kashmiri population (North India).

    abstract：PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2018.02.006

    authors： Shehjar F,Afroze D,Misgar RA,Malik SA,Laway BA

    更新日期：2018-04-01 00:00:00

  • Elevation of HLA-G-expressing DC-10 cells in patients with gastric cancer.

    abstract：:DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2016.01.003

    authors： Xu DP,Shi WW,Zhang TT,Lv HY,Li JB,Lin A,Yan WH

    更新日期：2016-09-01 00:00:00

  • Prevalence of AT1R antibody (AT1R-Ab) among Malaysian multi-ethnic population.

    abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2020.07.005

    authors： Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

    更新日期：2020-12-01 00:00:00

  • Attenuated expression of interferon-β and interferon-λ1 by human alternatively activated macrophages.

    abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.08.267

    authors： El Fiky A,Perreault R,McGinnis GJ,Rabin RL

    更新日期：2013-12-01 00:00:00

  • The complexity of DRw6 and DR5 haplotypes in American blacks demonstrated by serology, cellular typing, and restriction fragment length polymorphism analysis.

    abstract：:This study describes the diversity of DRw6 and DR5 haplotypes in the American black population using serology, cellular typing, and restriction fragment length polymorphism (RFLP) analysis. DRw6 (DRw13 and DRw14) and DR5 (DRw11 and DRw12) haplotypes are observed at a high frequency in this population (DRw6: 32%, DR5: ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90115-6

    authors： Lee KW,Hurley CK,Hartzman R,Johnson AH

    更新日期：1990-11-01 00:00:00

  • Quantitation of soluble HLA class I heterodimers and beta 2-microglobulin in patients with active pulmonary tuberculosis.

    abstract：:Beta 2m serum levels have been shown to be increased in patients with tuberculosis and HIV infection. We determined the stability of beta 2m and of sHLA-I dimers in serum, and then determined the levels of both molecules in 60 non-HIV-infected patients with active pulmonary tuberculosis and in 55 adult controls. The l...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)90066-3

    authors： Inostroza J,Muñoz P,Espinoza R,Millaqueo L,Diaz P,Leiva L,Sorensen R

    更新日期：1994-07-01 00:00:00

  • Alleles and genotypes of polymorphisms of IL-18, TNF-α and IFN-γ are associated with a higher risk and severity of hepatocellular carcinoma (HCC) in Brazil.

    abstract：:Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver. We evaluated the association of alleles and genotypes of polymorphisms of IL-18 (-607C/A and -137G/C), IFN-γ (+874T/A) and TNF-α (-238G/A and -308G/A) with the risk and severity of HCC. One-hundred-and-twelve patients with HCC and 202 healthy co...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2013.04.029

    authors： Teixeira AC,Mendes CT Jr,Marano LA,Deghaide NH,Secaf M,Elias J Jr,Muglia V,Donadi EA,Martinelli AL

    更新日期：2013-08-01 00:00:00

  • STAT4 polymorphism in a Chinese Han population with Vogt-Koyanagi-Harada syndrome and Behçet's disease.

    abstract：:This study investigated the association of rs7574865 polymorphism in STAT4 with Vogt-Koyanagi-Harada (VKH) syndrome and Behçet's disease (BD) in a Chinese Han population. Genotyping of rs7574865 polymorphism in the STAT4 gene was performed using polymerase chain reaction restriction fragment length polymorphisms in 37...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2010.04.007

    authors： Hu K,Yang P,Jiang Z,Hou S,Du L,Li F

    更新日期：2010-07-01 00:00:00

  • Emerging role of donor-specific anti-human leukocyte antigen antibody determination for clinical management after solid organ transplantation.

    abstract：:Preformed and de novo donor-specific HLA antibodies (DSA) have been associated with allograft dysfunction and failure. The application of solid-phase methods have increased the sensitivity and specificity of antibody detection; however the clinical significance of these DSA is under evaluation. In the present study, w...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2009.06.009

    authors： Zeevi A,Lunz JG 3rd,Shapiro R,Randhawa P,Mazariegos G,Webber S,Girnita A

    更新日期：2009-08-01 00:00:00

  • Analysis of the distribution of HLA-B alleles in populations from five continents.

    abstract：:A two stage PCR-SSOP typing procedure, that permitted HLA-B allele assignment, was applied to DNA samples obtained from six diverse populations -Brazilian, Mexican (Series and Mestizos), Cuban (Caucasoid and Mulatto), South African Zulu, Omani, and Singapore Chinese. HLA-B allele frequencies and HLA-A/B two locus hapl...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(01)00247-6

    authors： Williams F,Meenagh A,Darke C,Acosta A,Daar AS,Gorodezky C,Hammond M,Nascimento E,Middleton D

    更新日期：2001-06-01 00:00:00

  • Association of HLA-DR and -DQ genes with Graves disease in Koreans.

    abstract：:Graves disease (GD) is an autoimmune thyroid disease and is associated with human leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 and -DQB1 associations with GD in 198 Korean patients compared with 200 he...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2005.03.001

    authors： Park MH,Park YJ,Song EY,Park H,Kim TY,Park DJ,Park KS,Cho BY

    更新日期：2005-06-01 00:00:00

  • Modulation of LILRB2 protein and mRNA expressions in septic shock patients and after ex vivo lipopolysaccharide stimulation.

    abstract：:Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2017.03.010

    authors： Venet F,Schilling J,Cazalis MA,Demaret J,Poujol F,Girardot T,Rouget C,Pachot A,Lepape A,Friggeri A,Rimmelé T,Monneret G,Textoris J

    更新日期：2017-01-01 00:00:00

  • RFLP-defined HLA-DP polymorphism in four ethnic groups.

    abstract：:Patterns of BglII, MspI, and TaqI DP alpha and DP beta hybridizing restriction fragment length polymorphisms are compared with primed lymphocyte typing--determined specificities in 28 10th International Histocompatibility Workshop core cell lines. Correlation of specific RFLP patterns with most recognized DP types is ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(89)90080-3

    authors： Easteal S,Voorhoeve AH,Zimmet P,Serjeantson SW

    更新日期：1989-07-01 00:00:00

  • Allele and haplotype frequencies for HLA class II (DQA1 and DQB1) loci in patients with celiac disease from Spain.

    abstract：:Celiac disease (CD) is a complex and multifactorial disease, defined as a malabsorptive disorder of the small intestine resulting from ingestion of gluten. Genetic susceptibility to CD has been associated with human leukocyte antigen (HLA)-DQ2 heterodimer, encoded by the DQA1*0501 and DQB1*02 genes. However, HLA risk ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2003.12.014

    authors： Vidales MC,Zubillaga P,Zubillaga I,Alfonso-Sánchez MA

    更新日期：2004-04-01 00:00:00

  • Polymorphisms within the HLA-DRw6 haplotype. III. DQ alpha and DQ beta polymorphism associated with HLA-D.

    abstract：:We have studied HLA-DQ encoded antigens from HLA-DRw6 homozygous cells and analyzed the DQ region at the DNA level. HLA-DQ molecules were isolated from EBV transformed B-cell lines and analyzed for DQ alpha and DQ beta polymorphism. From the same set of cells, DNA was isolated and analyzed for RFLP. Polymorphism could...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(87)90097-8

    authors： Bosch ML,Fei H,Bontrop RE,Gerrets R,Tilanus MG,Termijtelen A,Giphart MJ

    更新日期：1987-06-01 00:00:00

  • Rapid evaluation of soluble HLA-G levels in supernatants of in vitro fertilized embryos.

    abstract：:Human leukocyte antigen G (HLA-G) molecules are crucial for the maternal tolerance against the fetus during pregnancy. Thus, the presence of soluble HLA-G (sHLA-G) in embryo cultures is thought to be correlated to a successful pregnancy after assisted reproductive techniques (ART). Here, we established a rapid detecti...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2006.11.003

    authors： Rebmann V,Switala M,Eue I,Schwahn E,Merzenich M,Grosse-Wilde H

    更新日期：2007-04-01 00:00:00

  • Cd4(+) T cell response to Leishmania spp. in non-infected individuals.

    abstract：:T cell mediated immunity is known to play a central role in the host response to control intra-cellular pathogens. This work demonstrates the presence of specific CD4(+) T cells to Leishmania spp. antigens in peripheral mononuclear cells of naïve individuals (normal volunteers from non-endemic regions). The responder ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00119-1

    authors： Gabaglia CR,Valle MT,Fenoglio D,Barcinski MA,Manca F

    更新日期：2000-06-01 00:00:00

  • Soluble HLA in human body fluids.

    abstract：:There is a growing body of information about the soluble forms of HLA in serum but there are only a few reports discussing sHLA in other body fluids. We quantitated sHLA-I and sHLA-II concentrations in sweat, saliva and tear samples from five normal individuals with known HLA-phenotypes. We also studied sweat samples ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00122-0

    authors： Aultman D,Adamashvili I,Yaturu K,Langford M,Gelder F,Gautreaux M,Ghali GE,McDonald J

    更新日期：1999-03-01 00:00:00

  • HLA class I and class II allele and haplotype distribution in the Venezuelan population.

    abstract：:Population studies represent an integral part, and a necessary link in a complex chain of host-pathogen interactions, disease pathogenesis, and major histocompatibility complex polymorphism. HLA class I and class II allele and haplotype distributions among Venezuelan mestizos were determined. Genes of Mongoloid, Negro...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(97)00088-8

    authors： Makhatadze NJ,Franco MT,Layrisse Z

    更新日期：1997-06-01 00:00:00

  • Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: comparison to other interferons.

    abstract：:This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as fo...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(85)90022-9

    authors： Capobianchi MR,Ameglio F,Tosi R,Dolei A

    更新日期：1985-05-01 00:00:00

  • Molecular cloning and characterization of cynomolgus monkey Fas.

    abstract：:The Fas-FasL system plays a crucial role in the maintenance of homeostasis in the immune system. To characterize the Fas/FasL system in macaque monkeys that are commonly used as experimental primates, we cloned and sequenced Fas cDNA derived from the cynomolgus monkey. The predicted amino acid sequence consists of 331...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00100-2

    authors： Murayama Y,Terao K,Inoue-Murayama M

    更新日期：2000-05-01 00:00:00

  • Serological, functional, and immunochemical characterization of a monoclonal antibody (MoAb Q2/70) to human Ia-like antigens.

    abstract：:Serological and immunochemical studies showed that monoclonal antibody Q2/70 (MoAb Q2/70), produced by the hybridoma technique, is specific for human Ia-like antigens. This antibody recognizes an antigenic determinant which is different from those defining the serologic polymorphism of Ia-like antigens, and is express...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(80)90016-6

    authors： Quaranta V,Indiveri F,Glassy MC,Ng A,Russo C,Molinaro GA,Pellegrino MA,Ferrone S

    更新日期：1980-10-01 00:00:00

  • MHC class I and class II phenotype, gene, and haplotype frequencies in Greeks using molecular typing data.

    abstract：:In the present study, DNA typing for HLA-A, C, B, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 was performed for 246 healthy, unrelated Greek volunteers of 20-59 years of age. Phenotype, genotype frequencies, Hardy-Weinberg equilibrium fit, and 3-locus haplotype frequencies for HLA-A, C, B, HLA-A, B, DRB1, HLA-DRB1, D...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(00)00115-4

    authors： Papassavas EC,Spyropoulou-Vlachou M,Papassavas AC,Schipper RF,Doxiadis IN,Stavropoulos-Giokas C

    更新日期：2000-06-01 00:00:00

  • Pathway analysis of genome-wide association study on asthma.

    abstract：OBJECTIVE:The aims of this study were to identify the candidate causal single nucleotide polymorphisms (SNPs) and candidate causal mechanisms of asthma and to generate SNP to gene to pathway hypotheses. METHODS:SNPs that met a threshold of p ≤ 0.001 in a genome-wide association study (GWAS) dataset of asthma, which in...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2012.11.003

    authors： Song GG,Lee YH

    更新日期：2013-02-01 00:00:00

  • A novel DR beta 1*03 allele identified by polymerase chain reaction-restriction fragment length polymorphism.

    abstract：:This report describes a new MHC class II allele, HLA-DR beta 1*0306, discovered in a 31-year-old Norwegian male. The allele typed serologically as DRw52 (DR3) and amplified in PCR using DR52-associated group primers. This product could not be identified using established restriction digests, however. Use of Asp 700, M...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(95)00175-1

    authors： Fenske B,Lemieux J,Hoar D,Fitzpatrick J,Keown P

    更新日期：1996-03-01 00:00:00

  • Polymorphism of DRw52 and its association with DRw11 and DRw12 in South African blacks (Negroes) and individuals of mixed ancestry (Cape coloreds).

    abstract：:The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 h...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90100-4

    authors： Martell RW,Oudshoorn M,Arendse B,du Toit ED

    更新日期：1990-05-01 00:00:00

  • HLA-DRw52a is involved in alloimmunization against PL-A1 antigen.

    abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(90)90104-w

    authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

    更新日期：1990-02-01 00:00:00

  • Differences in peptide binding of DR11 and DR13 microvariants demonstrate the power of minor variation in generating DR functional diversity.

    abstract：:The influence of subtle HLA diversification on antigen binding was explored using murine L-cell transfectants expressing alleles in the DR11/DR13 family and a panel of peptides. The levels of binding among this family of DR microvariants were as diverse as the levels of binding among distantly related DR molecules. Ev...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/0198-8859(94)00157-l

    authors： Hurley CK,Steiner N

    更新日期：1995-06-01 00:00:00

  • A clonal culture assay for human cord blood lymphohematopoietic progenitors.

    abstract：:We describe a two-step clonal culture assay system for human lymphohematopoietic progenitors present in umbilical cord blood which are capable of differentiation along both myeloid and B-lymphoid lineages. Human cord blood CD34+ cells were plated in methylcellulose in the presence of stem cell factor (SCF), granulocyt...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/s0198-8859(98)00094-9

    authors： Yoshikawa Y,Ikebuchi K,Ohkawara J,Hirayama F,Yamaguchi M,Sato N,Mori KJ,Kasai M,Sekiguchi S

    更新日期：1999-01-01 00:00:00

  • Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.

    abstract：:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberc...

    journal_title：Human immunology

    pub_type： 杂志文章

    doi：10.1016/j.humimm.2007.09.003

    authors： Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MR

    更新日期：2007-11-01 00:00:00