Abstract:
:The C-type lectin DC-SIGN (CD209) is an important pathogen recognition receptor of the innate immune system. Recent studies showed that DC-SIGN is the major receptor of Mycobacterium tuberculosis on human dendritic cells and that polymorphisms in the DC-SIGN promoter region are associated with susceptibility to tuberculosis. In this light, we aimed to study the potential implication of DC-SIGN genetic variation in the predisposition to tuberculosis in a group of Tunisian patients. We thus performed an association study comprising 138 tuberculosis patients and 140 healthy controls. Sequencing of the DC-SIGN promoter region detected four polymorphisms (-939, -871, -601, and -336), but no differences in their allelic distribution were observed between the two groups. In addition, the analysis of length variation in the DC-SIGN neck region indicated extremely low levels of polymorphisms and, again, no differences between patients and controls. Our data showed therefore that neither promoter variants nor length variation in the neck region of DC-SIGN is associated with susceptibility to tuberculosis in Tunisian patients.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Ben-Ali M,Barreiro LB,Chabbou A,Haltiti R,Braham E,Neyrolles O,Dellagi K,Gicquel B,Quintana-Murci L,Barbouche MRdoi
10.1016/j.humimm.2007.09.003subject
Has Abstractpub_date
2007-11-01 00:00:00pages
908-12issue
11eissn
0198-8859issn
1879-1166pii
S0198-8859(07)00437-5journal_volume
68pub_type
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