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Interleukin-1RN gene polymorphisms in elderly patients with rheumatic inflammatory chronic conditions: Association of IL-1RN*2/2 genotype with polymyalgia rheumatica.

Abstract：

:The objective of this study was to investigate whether there is an association between IL1RN polymorphism and disease susceptibility for three age-related inflammatory conditions: polymyalgia rheumatica (PMR), giant cell arteritis (GCA), and elderly-onset rheumatoid arthritis (EORA). A tandem-repeat polymorphism within IL1RN intron 2 was analyzed in 139 PMR, 69 GCA, and 156 RA patients (75 with EORA) as well as in 437 healthy subjects, together with the in vitro production of IL-1beta. Our results showed that the IL1RN*2/2 genotype was more frequent in PMR patients compared with controls (p = 0.032, odds ratio = 1.785, 95% confidence interval = 1.047-3.044) and GCA patients (p = 0.008, odds ratio = 4.661, 95% confidence interval = 1.352-16.065). We found no difference in the distribution of genotypes between PMR and EORA or between EORA and controls. However, the frequency of the IL-1RN*2/2 genotype had a tendency to be higher in patients with EORA compared with young onset RA. The presence of IL1RN*1 or IL1RN*2 allele was not associated with severity of the disease in PMR and GCA patients and did not influence the production of IL-1beta. In conclusion, the IL1RN*2 polymorphism in a homozygous state was associated with an increased susceptibility to PMR and may give some clues for a differential therapy with GCA.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Alvarez-Rodriguez L,Carrasco-Marin E,Lopez-Hoyos M,Mata C,Fernandez-Prieto L,Ruiz-Soto M,Calvo J,Rodriguez-Valverde V,Ruiz T,Blanco R,Corrales A,Martinez-Taboada VM

doi

10.1016/j.humimm.2008.10.011

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

49-54

issue

1

eissn

0198-8859

issn

1879-1166

pii

S0198-8859(08)00516-8

journal_volume

70

pub_type

杂志文章

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