Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma.

abstract：:In this study, the polymorphisms of the HLA DMA and DMB genes in patients with rheumatoid arthritis (RA) were examined.DMA and DMB typing was performed in 120 white RA patients from eastern France and 100 healthy controls, using PCR-SSO (sequence specific oligonucleotide probes) method for DMA determination and PCR-RF...

journal_title：Human immunology

authors： Toussirot E,Sauvageot C,Chabod J,Ferrand C,Tiberghien P,Wendling D

更新日期：2000-03-01 00:00:00

abstract：:An independent pool of 16 incompatible live donor-recipient pairs registered at the Vienna transplant unit was applied to test whether virtual crossmatch allocation used in the Australian kidney paired donation (KPD) program reliably predicts negative crossmatches. High resolution HLA data were entered into the comput...

journal_title：Human immunology

authors： Böhmig GA,Fidler S,Christiansen FT,Fischer G,Ferrari P

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to test whether the functional variant rs2076530 of the BTNL2 gene confers susceptibility to the autoimmune diseases type 1 diabetes (T1D), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). Our study populations consisted of 326 patients with T1D and 351 healthy subjects, 808...

journal_title：Human immunology

authors： Orozco G,Eerligh P,Sánchez E,Zhernakova S,Roep BO,González-Gay MA,López-Nevot MA,Callejas JL,Hidalgo C,Pascual-Salcedo D,Balsa A,González-Escribano MF,Koeleman BP,Martín J

更新日期：2005-12-01 00:00:00

abstract：:Two groups of residents in an endemic area of Leishmania major infection in Iran with positive leishmanin skin tests who were either asymptomatic or had healed cutaneous leishmaniasis lesions were compared with respect to their T helper responses. The percentages of regulatory T cells (Treg; CD4(+)CD25(high) FoxP3(+))...

journal_title：Human immunology

authors： Bahrami F,Darabi H,Riazi-Rad F,Khaze V,Ajdary S,Alimohammadian MH

更新日期：2014-10-01 00:00:00

abstract：:Basophils are the rare granulocytes and play an important role in the polarization of Th2 responses and protection against helminth parasites. In addition, basophils contribute to the pathogenesis of several diseases such as asthma, chronic allergy and lupus. Notably, Th17 cells are also implicated in the pathogenesis...

journal_title：Human immunology

authors： Sharma M,Stephen-Victor E,Poncet P,Kaveri SV,Bayry J

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Angiotensin II type 1 receptor antibody (AT1R-Ab) is a non-HLA antibody that has been reported to cause antibody-mediated rejection and graft loss in kidney transplantation. The prevalence of positive AT1R-Ab varies between 8% and 18% in different regions. Thus, this study aims to determine the prevalence of...

journal_title：Human immunology

authors： Jalalonmuhali M,Caroll R,Deayton S,Emery T,Humphreys I,Lim SJ,Lim SK,Coates T

更新日期：2020-12-01 00:00:00

abstract：:Haplotype V at the Y-chromosome specific DNA polymorphism (p49/TaqI) was reported in a study concerning 487 males originating from five different geographic locations in Iberia and North Africa. The highest frequency of haplotype V (68.9%) was previously observed in Berbers from Morocco, and it was previously establis...

journal_title：Human immunology

authors： Lucotte G,Gérard N,Mercier G

更新日期：2001-09-01 00:00:00

abstract：:Platelet alloimmunization may result in post-transfusion purpura, and during pregnancy may cause neonatal alloimmune thrombocytopenia (NAIT), with a frequency estimated at 1.3 per 1000 live births. The risk of morbidity is significant: 20% of affected infants have neurologic sequelae and the death rate is about 10%. A...

journal_title：Human immunology

authors： Semana G,Zazoun T,Alizadeh M,Morel-Kopp MC,Genetet B,Kaplan C

更新日期：1996-04-01 00:00:00

abstract：:Pronase treatment is used in the flow cytometry crossmatch (FCXM) to prevent nonspecific antibody binding on B cells. However, we have observed unexpected positive results with pronase-treated T cells in human immunodeficiency virus (HIV)-infected patients. In this study, 25 HIV-infected patients without HLA antibodie...

journal_title：Human immunology

authors： Szewczyk K,Barrios K,Magas D,Sieg K,Labuda B,Jendrisak MD,Jaramillo A

更新日期：2016-06-01 00:00:00

abstract：:Interleukin (IL)-1 gene polymorphisms affect several inflammatory diseases, including cancer. Therefore, we studied genetic association of biallelic (-511C>T) polymorphism of IL-1 beta and 86-bp VNTR polymorphism of IL-1RN in 159 patients with esophageal cancer (EC) and 194 age- and gender-matched healthy controls. Ge...

journal_title：Human immunology

authors： Upadhyay R,Jain M,Kumar S,Ghoshal UC,Mittal B

更新日期：2008-03-01 00:00:00

abstract：:Ninety healthy and unrelated volunteers were randomly selected to study the gene frequencies of Killer-cell immunoglobulin-like receptors (KIRs) in a Chilean (Talca) population. KIR typing was resolved by PCR-single specific primer (SSP), and their gene frequencies were calculated by direct counting of the number of p...

journal_title：Human immunology

authors： Castro-Santos P,Verdugo RA,Díaz-Peña R

更新日期：2018-09-01 00:00:00

abstract：:We have characterized the T lymphocyte population of the human neonate in respect of the expression of phenotypic profiles for naive, memory and differentiated populations. We have examined the response of the neonate T cell to the superantigen Staphylococcus enterotoxin B (SEB) and compared the response to T cells fr...

journal_title：Human immunology

authors： Macardle PJ,Wheatland L,Zola H

更新日期：1999-02-01 00:00:00

abstract：:The aim of this study was to examine the role of single nucleotide polymorphisms (SNPs) and haplotypes of the tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene in Hungarians with psoriasis and psoriatic arthritis. A case-control study was performed, and five TNFSF15 SNPs (rs3810936, rs6478108, rs647810...

journal_title：Human immunology

authors： Képíró L,Széll M,Kovács L,Keszthelyi P,Kemény L,Gyulai R

更新日期：2014-02-01 00:00:00

abstract：:The role of HLA antigens in lymphocyte differentiation is strongly suggested by the existence of a recently identified immunodeficiency associated with, and probably resulting from, the lack of expression of HLA-A, B, and C antigens as well as beta2 microglobulin on various cells of hematopoietic origin. This "bare ly...

journal_title：Human immunology

authors： Touraine JL,Bétuel H

更新日期：1981-03-01 00:00:00

abstract：:Prevention of rejection and the induction of transplantation tolerance are two related but separable phenomena that must both be considered in the analysis of the response to a transplanted organ. It is frequently hard to separate these phenomena in assessing the outcome of clinical transplants, because patients are r...

journal_title：Human immunology

authors： Gianello PR,Sachs DH

更新日期：1996-09-15 00:00:00

abstract：:The nonclassical MHC class I HLA-G antigen is expressed in cytotrophoblasts during pregnancy and may play a role in inhibiting lysis by maternal natural killer cells. HLA-G gene transcription was analyzed in human fetal liver of 6-8 wk of gestation, a development stage where classical HLA class I expression is very re...

journal_title：Human immunology

authors： Moreau P,Lefebvre S,Gourand L,Dausset J,Carosella ED,Paul P

更新日期：1998-12-01 00:00:00

abstract：:We have studied HLA-DQ encoded antigens from HLA-DRw6 homozygous cells and analyzed the DQ region at the DNA level. HLA-DQ molecules were isolated from EBV transformed B-cell lines and analyzed for DQ alpha and DQ beta polymorphism. From the same set of cells, DNA was isolated and analyzed for RFLP. Polymorphism could...

journal_title：Human immunology

authors： Bosch ML,Fei H,Bontrop RE,Gerrets R,Tilanus MG,Termijtelen A,Giphart MJ

更新日期：1987-06-01 00:00:00

abstract：:This study presents a comparative analysis of the effects of different interferons (IFN) on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell types. The results can be summarized as fo...

journal_title：Human immunology

authors： Capobianchi MR,Ameglio F,Tosi R,Dolei A

更新日期：1985-05-01 00:00:00

abstract：:The expression of HLA-A, B, C, and DR antigens was investigated on monocyte preparations by flow cytometry using various monoclonal antibodies. Essentially all human monocytes, either freshly isolated or after culture for several days, were stained for HLA-A, B, C, and DR antigens. When monocytes were incubated with C...

journal_title：Human immunology

authors： Nunez G,Stastny P

更新日期：1983-01-01 00:00:00

abstract：:The purpose of this study was to identify polymorphic residues of DQ2 beta chains which are involved in the epitopes recognized by DQ2-reactive mAbs. Binding studies were performed on a panel of DQ2 mutant cells made by transfection of a DQ (alpha 1*0501, beta 1*0301)-positive B-LCL with DQB1 genes encoding either wil...

journal_title：Human immunology

authors： Viken HD,Paulsen G,Drover S,Marshall WH,Sollid LM,Gaudernack G,Thorsby E

更新日期：1995-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell act...

journal_title：Human immunology

authors： Liu Y,Liang WB,Gao LB,Pan XM,Chen TY,Wang YY,Xue H,Zhang LS,Zhang L

更新日期：2010-11-01 00:00:00

abstract：:Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellu...

journal_title：Human immunology

authors： Singh B,Anbalagan S,Selvaraj P

更新日期：2017-01-01 00:00:00

abstract：:The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are c...

journal_title：Human immunology

authors： Deulofeut H,Wilderson JL,Barron KS,Robinson MA

更新日期：1995-07-01 00:00:00

abstract：:Hepatitis E virus (HEV) causes high mortality among pregnant women. Pathogenesis of HEV, especially during pregnancy, is poorly understood. Our aim was to assess the role of Toll-like-receptors (TLRs) in hepatitis E patients with pregnancy (Antenatal care, ANC) or without pregnancy (non-ANC). The patient categories in...

journal_title：Human immunology

authors： Arya RP,Arankalle VA

更新日期：2014-12-01 00:00:00

abstract：:Signal transducer and activator of transcription 4 (STAT4) has been recently identified as a susceptibility gene for multiple autoimmune diseases. Here we performed a comprehensive analysis of the association between STAT4 and several different autoimmune disorders to identify potential common inflammatory principles ...

journal_title：Human immunology

authors： Zheng J,Yin J,Huang R,Petersen F,Yu X

更新日期：2013-08-01 00:00:00

abstract：:Sarcoidosis is a multisystem granulomatous disorder of unknown etiology. Hereditary etiology has been proposed as a cause of the sarcoidosis, and some Human Leucocyte Antigen (HLA) alleles have been related to the diagnosis or severity of the disease. Löfgren's syndrome has been linked to patients with the DRB1*03 all...

journal_title：Human immunology

authors： da Costa CH,Silva VL,Fabricio-Silva GM,Usnayo M,Rufino R,Porto LC

更新日期：2013-10-01 00:00:00

abstract：:A novel cell surface molecule, DN4, defined by an mAb raised against human thymic epithelial cells, showed a specificity for epithelial cells of the thymic cortex. This antigen was not expressed at detectable levels on any other types of tissues in the human body except for the thymus and bone marrow. Immunohistochemi...

journal_title：Human immunology

authors： Chung DH,Choi EY,Lee GK,Bae YM,Hahn JH,Kim SS,Song HG,Park WS,Ahn HS,Park SH

更新日期：1996-02-01 00:00:00

abstract：:The capacity of MHC class I to protect target cells from NK is well established, but the mechanism by which these molecules influence NK recognition and the physical properties associated with this function remain poorly defined. We have examined this issue using as a model the HLA-A11 allele. HLA-A11 expression corre...

journal_title：Human immunology

authors： Gavioli R,Zhang QJ,Masucci MG

更新日期：1996-08-01 00:00:00

abstract：:Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...

journal_title：Human immunology

authors： Lanchbury JS,Sakkas LI,Marsh SG,Bodmer JG,Welsh KI,Panayi GS

更新日期：1989-09-01 00:00:00

abstract：:We have calculated six-locus high resolution HLA A∼C∼B∼DRB3/4/5∼DRB1∼DQB1 haplotype frequencies using all Be The Match(®) Registry volunteer donors typed by DNA methods at recruitment. Mixed resolution HLA typing data was inputted to a modified expectation-maximization (EM) algorithm in the form of genotype lists gene...

journal_title：Human immunology

authors： Gragert L,Madbouly A,Freeman J,Maiers M

更新日期：2013-10-01 00:00:00