Abstract:
:This present review concentrates on the recent results investigating the role of certain cytokine gene polymorphisms, including tumor necrosis factor alpha, interferon gamma, interleukin-6 (IL-6), IL-10, and IL-1 receptor antagonist, in allogeneic stem cell transplantation. The review discusses their potential role in predicting outcome and the development of a genetic risk index for graft-versus-host disease in human leukocyte antigen matched sibling transplants. By the comparative use of an in vitro human skin explant model, initial results suggest that certain polymorphisms may be associated with more severe disease.
journal_name
Hum Immunoljournal_title
Human immunologyauthors
Dickinson AM,Cavet J,Cullup H,Wang XN,Sviland L,Middleton PGdoi
10.1016/s0198-8859(01)00324-xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
1266-76issue
11eissn
0198-8859issn
1879-1166pii
S0198-8859(01)00324-Xjournal_volume
62pub_type
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