Penaeus monodon tropomyosin induces CD4 T-cell proliferation in shrimp-allergic patients.

abstract：:Rat soluble MHC class I synthesis was studied at both RNA and protein levels to determine whether multiple forms of soluble MHC class I molecules are produced by different mechanisms. RT-PCR and sequencing of MHC class I transcripts identified an alternatively spliced nonclassical MHC class I gene product, lacking bot...

journal_title：Human immunology

authors： Zhai Y,Knechtle S

更新日期：1998-07-01 00:00:00

abstract：:A proinflammatory cytokine interleukin-6 (IL-6) plays an important role in the development, pathogenesis and outcome of SIRS, sepsis and septic shock. We have evaluated the role of the IL-6 gene polymorphisms in pediatric patients. A total of 421 consecutive pediatric patients admitted to the pediatric intensive care ...

journal_title：Human immunology

authors： Michalek J,Svetlikova P,Fedora M,Klimovic M,Klapacova L,Bartosova D,Hrstkova H,Hubacek JA

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...

journal_title：Human immunology

authors： da Costa Lima Caniatti MC,Borelli SD,Guilherme AL,Tsuneto LT

更新日期：2017-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) may be related to chronic inflammation and immune-mediated conditions, and its pathogenesis involves T-cell activation and proliferation. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecules (CD80/CD86) genes are important mediators of T-cell act...

journal_title：Human immunology

authors： Liu Y,Liang WB,Gao LB,Pan XM,Chen TY,Wang YY,Xue H,Zhang LS,Zhang L

更新日期：2010-11-01 00:00:00

abstract：:Macrophages can be polarized into classically (CAM) or alternatively (AAM) activated macrophages with IFN-γ or IL-4, respectively. CAM are associated with type 1 immune responses and are implicated in autoimmunity; AAM are associated with type 2 responses and are implicated in allergic diseases. An impediment in inves...

journal_title：Human immunology

authors： El Fiky A,Perreault R,McGinnis GJ,Rabin RL

更新日期：2013-12-01 00:00:00

abstract：:The HLA-A, HLA-B and HLA-C molecules have turned out to be highly polymorphic and functionally complex. They not only serve as peptide receptors, but also interact with beta 2-microglobulin, an alpha beta T cell receptor, CD8 and NK inhibitory molecules, all at different sites. The fact that more than 300 class I alle...

journal_title：Human immunology

authors： Kostyu DD,Hannick LI,Traweek JL,Ghanayem M,Heilpern D,Dawson DV

更新日期：1997-09-15 00:00:00

abstract：:Population studies represent an integral part, and a necessary link in a complex chain of host-pathogen interactions, disease pathogenesis, and major histocompatibility complex polymorphism. HLA class I and class II allele and haplotype distributions among Venezuelan mestizos were determined. Genes of Mongoloid, Negro...

journal_title：Human immunology

authors： Makhatadze NJ,Franco MT,Layrisse Z

更新日期：1997-06-01 00:00:00

abstract：:In vitro primary sensitization of human peripheral blood T-cells to hemocyanins was detected during a 12-14 day culture period with antigen (KLH or HCH)-pulsed macrophages. Primed T-cells proliferate in secondary culture (2-3 days) when restimulated with antigen presented by macrophages. The kinetics of primary sensit...

journal_title：Human immunology

authors： Ford D,Hamblin A,Dumonde D,Burger D

更新日期：1982-06-01 00:00:00

abstract：:Sarcoidosis is a multiorgan granulomatous disease of unknown etiology. Several lines of evidence suggest a genetic predisposition and associations have been demonstrated with HLA antigens. HLA-DQB1 has been proposed as one of the candidate genes. To investigate the relationship between DQB1 and sarcoidosis at the alle...

journal_title：Human immunology

authors： Voorter CE,Drent M,van den Berg-Loonen EM

更新日期：2005-07-01 00:00:00

abstract：:Studies of HLA-G and HLA-E polymorphisms in different populations from many industrialized countries have uniformly reported little sequence variation within these genes. To date, the polymorphism of these genes has not been characterized in populations from developing countries where more sequence variation would be ...

journal_title：Human immunology

authors： Matte C,Lacaille J,Zijenah L,Ward B,Roger M

更新日期：2000-11-01 00:00:00

abstract：:Celiac disease (CD) follows an autoimmune course in which both genetic and environmental factors contribute to its development. A strong association with HLA class II molecules, predominantly HLA-DQ2, has been reported in most ethnic groups with CD. The aim of this study was to determine if genetic polymorphisms in L-...

journal_title：Human immunology

authors： Kaur G,Rapthap CC,Kumar S,Bhatnagar S,Bhan MK,Mehra NK

更新日期：2006-08-01 00:00:00

abstract：:In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukoc...

journal_title：Human immunology

authors： Gorski J,Niven MJ,Sachs JA,Mach B,Cassell PG,Festenstein H,Awad J,Hitman GA

更新日期：1987-12-01 00:00:00

abstract：:The association of HLA antigens and type I or "lupoid" CAH-C was investigated in a population of 52 Argentinian Caucasoid patients. When compared with a population of normal individuals of the same ethnic group (n = 197), a significant increase of HLA-DR6 was observed (68.6% in patients vs 17.3% in controls; RR = 12.3...

journal_title：Human immunology

authors： Fainboim L,Marcos Y,Pando M,Capucchio M,Reyes GB,Galoppo C,Badía I,Remondino G,Ciocca M,Ramonet M

更新日期：1994-10-01 00:00:00

abstract：:The human leukocyte antigen (HLA) genes are highly variable and are known to play an important role in disease outcomes, including infectious diseases. Prior knowledge of HLA polymorphisms in a population usually forms the basis for an effective case-control study design. As a prelude to future disease association ana...

journal_title：Human immunology

authors： Geretz A,Ehrenberg PK,Bouckenooghe A,Fernández Viña MA,Michael NL,Chansinghakule D,Limkittikul K,Thomas R

更新日期：2018-11-01 00:00:00

abstract：:Progress in hematopoietic cell transplantation has been greatly facilitated by our increasing knowledge of the HLA system, as well as by improved therapies for achieving sustained engraftment, preventing graft-versus-host disease, and protecting the patient from infection. Disparity for HLA genes can cause graft rejec...

journal_title：Human immunology

authors： Mickelson EM,Petersdorf E,Anasetti C,Martin P,Woolfrey A,Hansen JA

更新日期：2000-02-01 00:00:00

abstract：:Recipients of marrow grafts from HLA-identical, (including MLC non-reactive) sibling donors have a 40-50% incidence of acute graft vs. host disease (GVHD); the involvement of non-HLA linked, minor histocompatibility antigens (miHA) has been implicated. One of the target tissues of GVHD is the skin where morphological ...

journal_title：Human immunology

authors： Reinsmoen NL,Kersey JH,Bach FH

更新日期：1984-12-01 00:00:00

abstract：:HLA analysis of the family of a renal transplant patient revealed an extremely rare condition. On repeated typings the only demonstrable HLA antigens shown in the propositus were from the maternal haplotype, HLA-A11,-B46,-CW1,-DR14,-DQ1. No paternal antigens could be demonstrated either by serologic or by DNA-typing m...

journal_title：Human immunology

authors： van den Berg-Loonen EM,Savelkoul P,van Hooff H,van Eede P,Riesewijk A,Geraedts J

更新日期：1996-01-01 00:00:00

abstract：:The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analys...

journal_title：Human immunology

authors： Hurley CK,Fernandez-Vina M,Hildebrand WH,Noreen HJ,Trachtenberg E,Williams TM,Baxter-Lowe LA,Begovich AB,Petersdorf E,Selvakumar A,Stastny P,Hegland J,Hartzman RJ,Carston M,Gandham S,Kollman C,Nelson G,Spellman S,Sett

更新日期：2007-01-01 00:00:00

abstract：:Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing evidence that galectins are implicated in essential biological processes such as cellular communication, inflammation, differentiation and apoptosis. Galectin-3 is one of the best-known galectins, which is found in ver...

journal_title：Human immunology

authors： Zeinali M,Adelinik A,Papian S,Khorramdelazad H,Abedinzadeh M

更新日期：2015-10-01 00:00:00

abstract：:A murine monoclonal antibody (mAb), 928, that recognizes a cell surface antigen (928 Ag) on a human Epstein-Barr virus-transformed fetal liver-derived lymphoid progenitor cell line (FL4.4) was generated. The 928 mAb reacted with only FL4.4; it did not react with any other 57 cell lines tested. Two color flowcytometry ...

journal_title：Human immunology

authors： Kishi H,Okumura A,Tong JJ,Sugiyama E,Matsuno H,Minowada J,Kanai T,Nishimura Y,Muraguchi A

更新日期：1997-08-01 00:00:00

abstract：:Vitamin D deficiency is adversely associated with diseases characterized by inflammation. The combination of the high incidence of vitamin D deficiency in patients undergoing allogeneic stem cell transplants (SCT) and the potential role of vitamin D deficiency in influencing graft-versus-host disease led us to further...

journal_title：Human immunology

authors： Joseph RW,Bayraktar UD,Kim TK,St John LS,Popat U,Khalili J,Molldrem JJ,Wieder ED,Komanduri KV

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Leucocyte infiltration and activation in the central nervous system (CNS) is an important step in the pathogenesis of multiple sclerosis (MS). The Chemokine receptor 5 (CCR5) is implicated in immune cell migration and cytokine release in the CNS, and it was demonstrated to strongly contribute to CNS inflamma...

journal_title：Human immunology

authors： Troncoso LL,Pontillo A,Oliveira EML,Finkelszteijn A,Schneider S,Chies JAB

更新日期：2018-08-01 00:00:00

abstract：:Pregnancy can prime the maternal humoral immune response against paternal human leukocyte antigens (HLA) of the child. Previous studies have reported that formation of antibodies against inherited paternal HLA is associated with the presence of primed cytotoxic T lymphocytes (CTLs) specific for these antigens. Recentl...

journal_title：Human immunology

authors： van Kampen CA,Versteeg-vd Voort Maarschalk MF,Langerak-Langerak J,Roelen DL,Claas FH

更新日期：2002-06-01 00:00:00

abstract：:The 14-base pair (bp) polymorphism within the HLA-G gene has been investigated in heart transplant patients for the first time. The 14-bp polymorphism is associated with HLA-G mRNA stability and the patterns of alternative isoforms splicing, and therefore may influence the functionality of the HLA-G molecule. In heart...

journal_title：Human immunology

authors： Torres MI,Luque J,Lorite P,Isla-Tejera B,Palomeque T,Aumente MD,Arizon J,Peña J

更新日期：2009-10-01 00:00:00

abstract：:One of the major categories of disease-causing micro-organisms are viruses. New studies on many different viruses have shown that virus attachment and cell entry is often a multistep process, requiring many interactions between the virus and cell surface molecules. In this study, we have attempted to identify the cell...

journal_title：Human immunology

authors： Triantafilou M,Triantafilou K,Wilson KM

更新日期：2000-09-01 00:00:00

abstract：:By discriminating self from nonself and controlling the magnitude and class of immune responses, the immune system mounts effective immunity against virtually any foreign antigens but avoids harmful immune responses to self. These are two equally important and related but distinct processes, which function in concert ...

journal_title：Human immunology

authors： Jiang H,Chess L

更新日期：2008-11-01 00:00:00

abstract：:The difficulty of molecular typing of the HLA class I genes and the relevance of the genes of this region to disease susceptibility and transplantation have provided an impetus to develop useful typing markers. We have characterized by polymerase chain reaction analysis a new highly informative CA repeat localized app...

journal_title：Human immunology

authors： Grimaldi MC,Clayton J,Pontarotti P,Cambon-Thomsen A,Crouau-Roy B

更新日期：1996-12-01 00:00:00

abstract：:The HER-2/neu protein is overexpressed in approximately 20% of human adenocarcinomas and is a defined tumor antigen in breast cancer. The purpose of this study was to evaluate the endogenous HER-2/neu specific antibody response in 57 patients with colorectal cancer. HER-2/neu specific antibodies, titer > or = 1:100, w...

journal_title：Human immunology

authors： Ward RL,Hawkins NJ,Coomber D,Disis ML

更新日期：1999-06-01 00:00:00

abstract：:This study examined the performance of a tuberculosis (TB)-specific enzyme-linked immunospot assay in 48 patients awaiting liver transplantation. They were tested with T-SPOT.TB, tuberculin skin test (TST), and lymphocyte transformation test (LTT) using tuberculin as a stimulus. A questionnaire was used to gain inform...

journal_title：Human immunology

authors： Lindemann M,Dioury Y,Beckebaum S,Cicinnati VR,Gerken G,Broelsch CE,Wrighton-Smith P,Grosse-Wilde H

更新日期：2009-01-01 00:00:00

abstract：:The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 h...

journal_title：Human immunology

authors： Martell RW,Oudshoorn M,Arendse B,du Toit ED

更新日期：1990-05-01 00:00:00