T-cell receptor bias in patients with allergic bronchopulmonary aspergillosis.

Abstract:

:CD4(+) Th2 helper cell mediated immune responses have been shown to play a crucial role in the pathogenesis of ABPA. HLA and TCR are the candidate genes, which can influence the specificity of these responses. We have previously established a strong association of HLA DR2/5 in ABPA susceptibility. The study was designed to determine whether allergen specific T cell express a limited usage of T cell receptor (TCR) Vbeta gene repertoire in ABPA and to find an association of susceptible HLA-DR determinants with the identified TCR gene segments. TCR Vbeta typing was performed on antigen specific T cell lines from 14 ABPA and 12 nonABPA patients. The majority of ABPA patients (86%) expressed allergen specific T cells with Vbeta13 genes indicating its role in susceptibility, whereas in nonABPA controls, Vbeta1 genes T cell repertoires were predominantly expressed. The unrestricted pattern of Vbeta gene amplification seen before antigen stimulation suggests an oligoclonal expansion of a specific T cell population in response to the allergen Asp f 1 in ABPA and nonABPA patients. The increased usage of Vbeta13 in ABPA and Vbeta1 in nonABPA indicates their importance in susceptibility and resistance, respectively.

journal_name

Hum Immunol

journal_title

Human immunology

authors

Chauhan B,Hutcheson PS,Slavin RG,Bellone CJ

doi

10.1016/s0198-8859(02)00361-0

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

286-94

issue

4

eissn

0198-8859

issn

1879-1166

pii

S0198885902003610

journal_volume

63

pub_type

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