解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Transition-related healthcare intervention has recently been receiving worldwide attention. Given the increasing incidence of pediatric inflammatory bowel disease (IBD) and its lifelong impact, transitional care has become an important issue. In Japan, guidelines to support the autonomy of IBD patients durin...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000510652
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) is recognized as a minimally invasive and curative treatment for superficial gastrointestinal (GI) cancers. However, ESD is still challenging and time-consuming with a high risk of adverse events such as bleeding and perforation. Various traction methods have been explo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000511731
更新日期:2020-12-22 00:00:00
abstract:INTRODUCTION:Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. OBJECTIVES:The aim of this study was to establish a novel quantitative meth...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000511851
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000511589
更新日期:2020-11-18 00:00:00
abstract:BACKGROUND AND AIM:A recent basic study identified that Dicer is contained in exosomes derived from cancer cells and plays crucial roles in microRNA maturation and cancer development. Based on this novel basic concept, we analyzed the usefulness of serum exosomal Dicer as a diagnostic biomarker for gastrointestinal can...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510993
更新日期:2020-10-13 00:00:00
abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510353
更新日期:2020-10-08 00:00:00
abstract:INTRODUCTION:Multiple Lugol-voiding lesions (LVLs) in the esophagus increase the risk of synchronous and metachronous development of esophageal squamous cell carcinoma (ESCC). Chemoradiotherapy (CRT) following endoscopic submucosal dissection (ESD) may reduce the incidence of metachronous ESCC, but few studies have inv...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510368
更新日期:2020-09-29 00:00:00
abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000507570
更新日期:2020-05-18 00:00:00
abstract:INTRODUCTION:Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present st...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000506152
更新日期:2020-02-14 00:00:00
abstract:BACKGROUND:Symptoms caused by chronic pancreatitis (CP) are common but often elusive hampering therapeutic decisions. Though correlations of morphologic findings in imaging and clinical appearance remain vague. We aimed in investigating whether a distinct combination of clinical parameters can better define the extent ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000505646
更新日期:2020-02-11 00:00:00
abstract:OBJECTIVES:Recently, several studies have demonstrated the usefulness of endoscopic submucosal dissection (ESD) for residual or locally recurrent colorectal lesions after endoscopic treatment. However, the feasibility of ESD for recurrent rectal lesions after transanal endoscopic microsurgery (TEM) has not been fully i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000505619
更新日期:2020-02-05 00:00:00
abstract:BACKGROUND:The importance of microbiota infiltrating the gut mucus layer has been reported in the pathogenesis of various gastrointestinal and systemic diseases. However, little is known about the mucosa-associated microbiota (MAM) in healthy subjects. The present study aimed to clarify the characteristics of the gastr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000496102
更新日期:2020-01-01 00:00:00
abstract::Fructus has motivation effect on gastrointestinal tract. Hesperidin is extracts of Fructus, and we attempted to prove its effects on improving the gastrointestinal transmission function and determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. Constipation phenotypes were mea...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000501959
更新日期:2020-01-01 00:00:00
abstract:AIMS:Evaluating the accuracy of the modified Endoscopic ABC (Endo ABC) classification with an electronic endoscopy with narrow band imaging without magnification in diagnosing Helicobacter pylori (H. pylori)-infected gastritis. METHODS:A total of 576 patients were enrolled and they underwent modified Endo ABC. They we...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000498966
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Combinations of antitumor necrosis factor alpha (TNFα) and immunomodulators may be indicated in high-risk inflammatory bowel disease patients. Our aims were to compare disease course between children that did and did not step down to anti-TNFα monotherapy and to define risk factors for complicated disease cou...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000496273
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Westernization, above all associated changes in diet, has been postulated to be one of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn's disease and ulcerative colitis. SUMMARY:Diet represents a crucially important and intui...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000505368
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The gut-liver-axis presents the pathophysiological hallmark for multiple liver diseases and has been proposed to be modulated during stress and shock. Access to the gut-liver-axis needs crossing of the mucus and gut-vascular barrier. The role of β-adrenoreceptor-activation for both barriers has not been defi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000502112
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:At present, benefits of surgical resection and appropriate selection criteria in patients affected by both hepatic and pulmonary metastases of colorectal cancer (CRC) are under discussion. Our analysis focused on a surgical series of such patients and our final aim consisted in identifying potential pro...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000497223
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is a continuous diseases spectrum associated with obesity, type 2 diabetes, insulin resistance, and hyperlipidemia. Simple hepatic steatosis may progress to nonalcoholic steatohepatitis (NASH), even fibrosis and cirrhosis, and finally hepatocellular carcinoma. In rece...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000501851
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Determining the depth of invasion is important when considering therapeutic strategies for early gastric cancer (EGC). We determined the effects of learning the non-extension sign, that is, an index of T1b2 in EGC, on identifying its depth of invasion. METHODS:Endoscopic images of 40 EGC cases (20 showing p...
journal_title:Digestion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000498845
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Duodenal cancer is one of the extracolonic malignancies with known mortality in familial adenomatous polyposis (FAP) patients. Visualization of the major duodenal papilla (MDP) with a standard esophagogastroduodenoscopy (EGD) is currently insufficient because of the limited field of view. Full-spect...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000501476
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy for advanced gastric cancer is expected to improve prognoses. However, as there is no method to evaluate neoadjuvant chemotherapeutic efficacy before gastrectomy, some patients at high risk for a poor prognosis undergo gastrectomy. The aim of the present study was to investigate whet...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000500907
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Incidence of cholangiocarcinoma (CCA) in western countries is rising. In the palliative setting, chemotherapy is the only established treatment. The evidence for other treatments including locoregional therapy is low. However, such individual treatments are offered in a real-world setting. The aim of this st...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000500894
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve (VN), modulates the immune system in the body. Recent studies of VN stimulation (VNS) in vivo systems have shown that it plays an anti-inflammatory role through CAIP. Inflammatory...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000504474
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed a self-completion method of ESD using Endosaber to eliminate the need for an additional device or human assistance during the procedure. The aim of this study was to evaluate the technical fe...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000502771
更新日期:2019-09-27 00:00:00
abstract:INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000502953
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND/AIMS:In this report, we aimed to investigate the distribution and characterization of biomarker-immunolabeled ductal epithelium in advanced pancreatic ductal adenocarcinoma (PDAC). DESIGN:Eighteen patients with PDAC were medically diagnosed prior to being treated periodically. All clinical records were coll...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000492861
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Colonic endoscopic mucosal resection (EMR) is safe for patients without antithrombotic therapy; however, EMR is associated with several risks. This study was performed to evaluate the risk of delayed hemorrhage in patients undergoing EMR without antithrombotic therapy. METHODS:In the present retrospect...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000494455
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND AND AIM:Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000495749
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric ca...
journal_title:Digestion
pub_type: 杂志文章,meta分析,多中心研究,评审
doi:10.1159/000494407
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Despite the high prevalence of obstructive sleep apnea syndrome (OSAS), most individuals are unaware of its diagnosis. We assessed whether an upper gastrointestinal (GI) endoscopy can accurately predict the incidence of OSAS. METHODS:After endoscopic evaluation of laryngo-pharyngeal collapse, a total o...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000491385
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Crohn's disease (CD) is a chronic immune-mediated disorder of the gastrointestinal tract. The pathophysiological understanding of this disease is limited and no curative therapy is available so far. Therefore, most patients require long-lasting or even life-long immunosuppressive therapies for the suppressio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000488449
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma is one of the most lethal types of cancer with a 5-year survival rate of around 7%. Due to the relatively poor prognosis, the potential need of an effective chemoprevention is highly needed. SUMMARY:Different risk factors like smoking or hereditary tumour syndromes should be...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000485741
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000485179
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND AIM:Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METH...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000487045
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:The aim of this study was to compare the accuracy of magnifying endoscopy with narrow band imaging for the diagnosis of depth of invasion by Japan Esophageal Society (JES) classification and inter- and intraobserver agreement of JES intrapapillary capillary loop (IPCL) classification. METHODS:It was a r...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000489490
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Autoimmune hepatitis (AIH) is a relatively rare cause of liver dysfunction and may lead in some cases to acute liver failure (ALF). The aim of our study was to evaluate the clinical course and outcome of patients with AIH-induced ALF. METHODS:We retrospectively enrolled 32 patients with AIH-induced ALF...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000487940
更新日期:2018-01-01 00:00:00
abstract::This study was conducted to investigate whether chronic kidney disease (CKD) affects intestinal inflammation and intestinal motility and the underlying mechanisms. Rats were randomized into control group and uremic group. Uremia rats were induced by the 5/6 kidney resection, while the control went through the same pro...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000481618
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Gastric xanthomas are frequently observed in the stomach as small yellowish plaques or nodules. A close relationship among Helicobacter pylori infection, atrophic gastritis, and xanthomas has been reported. We assessed the clinicopathological features of gastric cancer with or without xanthomas. METHOD...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000481346
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND/AIMS:Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but als...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000484043
更新日期:2017-11-01 00:00:00