Corticosteroid Therapy Improves the Outcome of Autoimmune Hepatitis-Induced Acute Liver Failure.

Abstract:

BACKGROUND/AIMS:Autoimmune hepatitis (AIH) is a relatively rare cause of liver dysfunction and may lead in some cases to acute liver failure (ALF). The aim of our study was to evaluate the clinical course and outcome of patients with AIH-induced ALF. METHODS:We retrospectively enrolled 32 patients with AIH-induced ALF and 93 age- and sex-matched patients with chronic AIH (cAIH) who were enrolled at the University Clinic Essen from 1988 to 2014. All ALF patients were treated with corticosteroids after diagnosis. RESULTS:Overweight, higher γ-globulin levels, the absence of anti-smooth muscle antibodies and human leukocyte antigen (HLA) B8 and the presence of anti-mitochondrial antibodies and HLA DR7 were risk factors for an ALF vs chronic hepatitis manifestation of AIH. Liver histology was significantly more often typical for AIH in an ALF setting than in cAIH. The spontaneous survival rate was 91% and 97% in ALF and cAIH patients, respectively, at 6 months after diagnosis and only 1 patient in the ALF group developed sepsis under therapy. CONCLUSION:Liver biopsy in an AIH-mediated ALF setting was both safe and effective in diagnosing AIH. Corticosteroid therapy was not associated with high mortality or sepsis. Our findings suggest that corticosteroid treatment of AIH-mediated ALF may improve the outcome.

journal_name

Digestion

journal_title

Digestion

authors

Anastasiou OE,Dogan-Cavus B,Kucukoglu O,Baba H,Kahraman A,Gerken G,Schramm C,Canbay A

doi

10.1159/000487940

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

104-111

issue

2

eissn

0012-2823

issn

1421-9867

pii

000487940

journal_volume

98

pub_type

杂志文章
  • Distribution of hepatic nerve fibers in liver diseases.

    abstract::Autonomic hyperactivity with increased cardiac output and other manifestations occurs in patients with both cirrhosis and noncirrhotic portal hypertension. The role of the disordered hepatic autonomic innervation in the mediation of these abnormalities is unknown. We have studied the hepatic nerve network and associat...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201156

    authors: Jaskiewicz K,Voigt MD,Robson SC

    更新日期:1994-01-01 00:00:00

  • Ratio of urinary 6beta-hydroxycortisol to 17-hydroxycorticosteroids in patients with liver disease.

    abstract::The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198068

    authors: Eade OE,Maddison A,Leonard PJ,Wright R

    更新日期:1977-01-01 00:00:00

  • Effects of the soluble fibre pectin on intestinal cell proliferation, fecal short chain fatty acid production and microbial population.

    abstract:AIM:Although pectin, a dietary fibre, has been suggested to possess some trophic effects on the intestine, the mechanisms involved remain unclear. This study aimed to evaluate the effects of pectin on rat intestinal cell proliferation and the intraluminal environment. METHODS:Control and pectin-fed rats were given a f...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000069705

    authors: Fukunaga T,Sasaki M,Araki Y,Okamoto T,Yasuoka T,Tsujikawa T,Fujiyama Y,Bamba T

    更新日期:2003-01-01 00:00:00

  • The role of drug treatment in variceal bleeding.

    abstract::Pharmacological management of acute variceal hemorrhage appears to be effective in patients with liver cirrhosis. Somatostatin and presumably its longer-acting analog, octreotide, are more efficient and safer than other vasoconstrictors like vasopressin, terlipressin or their combination with nitroglycerin. Drug treat...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201115

    authors: Holstege A,Palitzsch KD,Schölmerich J

    更新日期:1994-01-01 00:00:00

  • Small intestinal edema had the strongest correlation with portal venous pressure amongst capsule endoscopy findings.

    abstract:BACKGROUND/AIM:Previous studies have reported small intestinal lesions in patients with portal hypertensive disease. However, the etiology of these lesions is not clear, as portal venous pressure was not measured in any of these studies. The aim of this study is to clarify the association between small intestinal lesio...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000338180

    authors: Takahashi Y,Fujimori S,Narahara Y,Gudis K,Ensaka Y,Kosugi Y,Maki K,Suzuki M,Matsushita Y,Fukuda T,Kanazawa H,Sakamoto C

    更新日期:2012-01-01 00:00:00

  • Amylase/creatinine clearance ratio and tubular proteinuria in acute pancreatitis.

    abstract::Amylase/creatinine clearance ratio (CAm/CCr), urinary protein concentration and urinary protein pattern were studied in 102 samples from 27 patients with acute pancreatitis and in 46 controls. Raised CAm/CCr, proteinuria and a tubular protein pattern were present in 74, 56 and 96% of the patients, respectively. Howeve...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198397

    authors: Lankisch PG,Wolfrum DI,Koop H,Winckler K

    更新日期:1979-01-01 00:00:00

  • Endoscopic Ultrasound Elastography as a Novel Diagnostic Method for the Assessment of Hardness and Depth of Invasion in Colorectal Neoplasms.

    abstract:INTRODUCTION:We aimed to compare the efficacy of endoscopic ultrasound elastography (EUS-EG) with that of magnifying chromoendoscopy (MCE) and endoscopic ultrasonography (EUS) for the diagnosis of the depth of invasion in colorectal neoplasms. This is an important clinical issue as the depth of invasion is associated w...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000511589

    authors: Esaki M,Yamamura T,Nakamura M,Maeda K,Sawada T,Mizutani Y,Ishikawa E,Suzuki H,Kuno T,Yamada K,Hasegawa I,Ishikawa T,Kakushima N,Furukawa K,Ohno E,Kawashima H,Hirooka Y,Fujishiro M

    更新日期:2020-11-18 00:00:00

  • Critical flicker frequency as a marker of hepatic encephalopathy in patients before and after transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000288522

    authors: Biecker E,Hausdörfer I,Grünhage F,Strunk H,Sauerbruch T

    更新日期:2011-01-01 00:00:00

  • Treatment of peptic ulcer.

    abstract::The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the infection is especially i...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000007522

    authors: Tytgat GN

    更新日期:1998-08-01 00:00:00

  • Glucagon, secretin and vasoactive intestinal polypeptide immunoreactivities in rat gut after jejuno-ileal bypass and resection.

    abstract::Jejuno-ileal bypass (JIB) and resection are associated with hyperplastic and other changes in residual functional gut. In studies on endocrine changes, circulating hormone levels are usually measured. In this study with Sprague-Dawley rats, glucagon, secretin and vasoactive intestinal polypeptide (VIP), immunoreactivi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199226

    authors: Murphy RF,Chen MH,Herlin PM,Gallavan RH,Joffe SN,Fischer JE

    更新日期:1985-01-01 00:00:00

  • Capsule endoscopy of the upper gastrointestinal tract -- the need for a second endoscopy.

    abstract:BACKGROUND AND AIMS:Capsule endoscopy (CE) has been recognised as an important investigational tool in the diagnosis of gastrointestinal disease. Studies have shown that CE can identify lesions in the upper gastrointestinal tract as well as in the small intestine. However, contrary to conventional oesophagogastroscopy ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000089959

    authors: Peter S,Heuss LT,Beglinger C,Degen L

    更新日期:2005-01-01 00:00:00

  • Carcinomas of the colon in Buffalo strain rats given intraperitoneal injections of methylazoxymethanol acetate.

    abstract::Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197946

    authors: Reuber MD

    更新日期:1976-01-01 00:00:00

  • Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome.

    abstract:BACKGROUND AND AIMS:Validity of the lactulose breath test (LBT) to diagnose small intestinal bacterial overgrowth (SIBO) has been questioned. Therefore, a study was planned to compare LBT with glucose breath test (GBT) to diagnose SIBO in irritable bowel syndrome (IBS) patients and controls. METHODS:175 diarrhea-predo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000336174

    authors: Rana SV,Sharma S,Kaur J,Sinha SK,Singh K

    更新日期:2012-01-01 00:00:00

  • Cold and hot snare endoscopic techniques for removal of the Bravo pH monitoring capsule.

    abstract:BACKGROUND:Currently, use of the Bravo capsule is a very common method for evaluating the gastroesophageal reflux because it has the advantage of being an intraesophageal catheter-free system. However, endoscopic removal of the capsule is necessary when technical problems or severe discomfort are present. Most frequent...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000194945

    authors: de Hoyos A,Esparza EA,Loredo ML

    更新日期:2009-01-01 00:00:00

  • Chronic Kidney Disease Elicits an Intestinal Inflammation Resulting in Intestinal Dysmotility Associated with the Activation of Inducible Nitric Oxide Synthesis in Rat.

    abstract::This study was conducted to investigate whether chronic kidney disease (CKD) affects intestinal inflammation and intestinal motility and the underlying mechanisms. Rats were randomized into control group and uremic group. Uremia rats were induced by the 5/6 kidney resection, while the control went through the same pro...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000481618

    authors: Yu C,Tan S,Wang Z,Deng B,Li J,Wang Q,Zhou C,Kang X,Yu Z,Zhuang S

    更新日期:2018-01-01 00:00:00

  • Interdigestive gastrointestinal motility and secretion of gastric acid and pancreatic enzymes in young cigarette smokers.

    abstract::The basal (interdigestive) gastrointestinal motor activity and the interdigestive gastric acid and pancreatic amylase secretion were determined in 10 young smokers (mean age 23 years) and 7 nonsmokers (mean age 26 years). There was no significant difference in the length of the interdigestive motor complex between smo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199018

    authors: Demol P,Singer MV,Hotz J,Dipp M,Goebell H

    更新日期:1984-01-01 00:00:00

  • Acute hepatic failure following transcatheter arterial embolization for the treatment of hepatocellular carcinoma.

    abstract::We conducted a retrospective analysis to evaluate the risk factors associated with the occurrence of acute hepatic failure following transcatheter arterial embolization (TAE) for hepatocellular carcinoma. From 1984 to 1993 we performed a total of 623 embolization procedures in 369 patients with both hepatocellular car...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201443

    authors: Katsushima S,Inokuma T,Oi H,Okamura J,Higashi T,Takeuchi R,Hidaka A,Shigeno C,Iida Y,Konishi J

    更新日期:1997-01-01 00:00:00

  • Self-Completion Method of Endoscopic Submucosal Dissection Using Endosaber without Any Other Device or Assistance: An ex vivo Porcine Model Study.

    abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed a self-completion method of ESD using Endosaber to eliminate the need for an additional device or human assistance during the procedure. The aim of this study was to evaluate the technical fe...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000502771

    authors: Esaki M,Minoda Y,Wada M,Sakisaka S,Tsuruta S,Hosokawa T,Matsuguchi T,Ichijima R,Suzuki S,Tamura Y,Iwao A,Yamakawa S,Irie A,Ihara E,Ogawa Y

    更新日期:2019-09-27 00:00:00

  • Changes in bacterial phagocytosis of macrophages in experimental ulcerative colitis.

    abstract::We previously reported that numerous macrophages which phagocytosed dextran sulfate sodium were observed to have accumulated in the mucosal lesions and in the spleen in experimental ulcerative colitis induced in mice with dextran sulfate sodium. In this paper, we investigated the bacterial phagocytic ability of macrop...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201236

    authors: Ohkusa T,Okayasu I,Tokoi S,Araki A,Ozaki Y

    更新日期:1995-01-01 00:00:00

  • Direct inhibition of gastrointestinal carbonic anhydrase by ethanol.

    abstract::Carbonic anhydrase (CA) was found to be equally susceptible to direct inhibition by ethanol, whether the enzyme originated from homogenates of rabbit gastric, duodenal, or ileal mucosa. When gastric mucosa was separated into a soluble (cytoplasmic) and a membrane fraction, the membrane CA was more susceptible to ethan...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198130

    authors: Newsome LR,Leitch GJ

    更新日期:1978-07-01 00:00:00

  • Appendicectomy prevalences in South African adolescents.

    abstract::From questioning 16,939 South African pupils of 16-18 years, in 56 high schools, mean prevalences of appendicectomies in representative segments of ethnic groups were found to be: rural Blacks 0.6%; urban Blacks 0.7%; Indians, 2.9%; Coloureds (Eur-African-Malay), 1.7%; Whites, 10.5%. Percentages in the sexes were simi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198762

    authors: Walker AR,Walker BF,Duvenhage A,Jones J,Ncongwane J,Segal I

    更新日期:1982-01-01 00:00:00

  • Proctitis and proctosigmoiditis--a need to identify the extent of disease in epidemiological surveys.

    abstract::Proctitis and proctosigmoiditis may be distinct clinical entities. The lesions are restricted to the rectum or extend proximally to involve the sigmoid colon, respectively. Barium enema examination should be normal proximal to the rectum and sigmoid colon. Histology is used merely to confirm the disease process. We pr...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201013

    authors: Jayanthi V,Chuah SY,Probert CS,Mayberry M,Mayberry JF

    更新日期:1993-01-01 00:00:00

  • Changes in glycoproteins of liver plasma membranes from rats treated with D-galactosamine.

    abstract::D-Galactosamine administration to rats (400 mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and 24 h after D-galactosamine injection. Plasma membrane 5'-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition w...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198373

    authors: Bertrand F,Veissiere D,Picard J

    更新日期:1979-01-01 00:00:00

  • Sleep dysfunction in Japanese patients with gastroesophageal reflux disease: prevalence, risk factors, and efficacy of rabeprazole.

    abstract:BACKGROUND AND AIM:Several studies performed in Western countries demonstrate the association between sleep dysfunction and gastroesophageal reflux disease (GERD), especially when nighttime heartburn is present. The purpose of this study was to examine the prevalence and risk factors of sleep dysfunction, and the effec...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000253849

    authors: Fujiwara Y,Kohata Y,Kaji M,Nebiki H,Yamasaki T,Sasaki E,Hayakawa T,Machida H,Tanigawa T,Watanabe K,Watanabe T,Tominaga K,Arakawa T

    更新日期:2010-01-01 00:00:00

  • Evaluation of the 75Se-l-selenomethionine test for pancreatic disease. Studies on gel filtration.

    abstract::Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198444

    authors: Pointner H,Kletter K

    更新日期:1980-01-01 00:00:00

  • Intestinal absorption and unmediated permeation of sugars in post-infective tropical malabsorption (tropical sprue).

    abstract::Differential absorption of D-xylose and 3-O-methyl-D-glucose, and unmediated intestinal permeation of lactulose and L-rhamnose has been investigated in 14 patients with diarrhoea following tropical exposure and in 16 healthy control subjects. Five had malabsorption of fat, D-xylose and B12 ('tropical malabsorption' (T...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199282

    authors: Cook GC,Menzies IS

    更新日期:1986-01-01 00:00:00

  • Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group.

    abstract:BACKGROUND/AIMS:Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS:An expert international group using the modified Delphi technique examined the q...

    journal_title:Digestion

    pub_type: 共识发展会议,杂志文章

    doi:10.1159/000219365

    authors: Modlin IM,Hunt RH,Malfertheiner P,Moayyedi P,Quigley EM,Tytgat GN,Tack J,Heading RC,Holtman G,Moss SF,Vevey NERD Consensus Group.

    更新日期:2009-01-01 00:00:00

  • Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients.

    abstract:BACKGROUND/AIMS:There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patien...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000326854

    authors: Kim JH,Kim SY,Jung ES,Jung SW,Koo JS,Kim JH,Yeon JE,Kwon SY,Lee SW,Byun KS,Lee CH

    更新日期:2011-01-01 00:00:00

  • Pancreatic secretory response to sham feeding in humans.

    abstract::We studied the pancreatic secretory response to sham feeding alone or during secretin infusion with and without administration of atropine in 10 human subjects. The magnitude of the response to sham feeding was compared to the response to cholecystokinin octapeptide. Sham feeding alone did not significantly increase p...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198753

    authors: Defilippi C,Solomon TE,Valenzuela JE

    更新日期:1982-01-01 00:00:00

  • Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes.

    abstract:BACKGROUND:The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM:To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS:Prepubertal children of ages 3-12 with either la...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000381895

    authors: Nwosu BU,Maranda L

    更新日期:2015-01-01 00:00:00