Abstract:
:Carbonic anhydrase (CA) was found to be equally susceptible to direct inhibition by ethanol, whether the enzyme originated from homogenates of rabbit gastric, duodenal, or ileal mucosa. When gastric mucosa was separated into a soluble (cytoplasmic) and a membrane fraction, the membrane CA was more susceptible to ethanol inhibition, but less susceptible to acetazolamide inhibition, than the soluble enzyme. Male rat liver CA is relatively insensitive to acetazolamide inhibition, while female rat liver CA shows a sensitivity similar to that of other tissues. We found ethanol inhibited male and female rat liver CA equally, indicating a different site, or mode, of inhibition for ethanol and acetazolamide.
journal_name
Digestionjournal_title
Digestionauthors
Newsome LR,Leitch GJdoi
10.1159/000198130subject
Has Abstractpub_date
1978-07-01 00:00:00pages
370-3issue
4eissn
0012-2823issn
1421-9867journal_volume
17pub_type
杂志文章相关文献
DIGESTION文献大全abstract::Recent studies have demonstrated the presence of both CCKA and CCKB receptors on dog and guinea pig pancreas. Although CCKA receptors are implicated in enzymatic secretion, biological effects of CCKB receptors are still unknown. We have previously found that a rat acinar pancreatic cell line (AR4-2J) possesses both re...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200381
更新日期:1990-01-01 00:00:00
abstract::Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198069
更新日期:1977-01-01 00:00:00
abstract::The effect of the long-acting somatostatin analogue Sandostatin (SMS 201-995) on intestinal absorption and propagation (mouth-to-caecum transit time; MCTT), on pancreatic secretion and on gall bladder contraction after direct (secretin-pancreozymin test) and indirect stimulation (Lundh meal), and on meal-induced respo...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000199408
更新日期:1987-01-01 00:00:00
abstract::We have shown that dietary long-chain triglycerides and 16,16-dimethyl prostaglandin E2 enhance and aspirin impairs postresection mucosal adaptation in rats. The present studies examined the hypothesis that supplemental linoleic acid (LA) above the minimum requirement may enhance postresection mucosal adaptation throu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199893
更新日期:1989-01-01 00:00:00
abstract::This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the vill...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199030
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND/AIMS:Autoimmune hepatitis (AIH) is a relatively rare cause of liver dysfunction and may lead in some cases to acute liver failure (ALF). The aim of our study was to evaluate the clinical course and outcome of patients with AIH-induced ALF. METHODS:We retrospectively enrolled 32 patients with AIH-induced ALF...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000487940
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:What naturally happens to patients after they undergo conservative and endoscopic treatment of colonic diverticular bleeding (CDB) is largely unknown. We retrospectively track the long-term outcome of the recurrence of CDB between patients with endoscopic and conservative treatment. METHODS:The group wa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000452301
更新日期:2016-01-01 00:00:00
abstract::The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007590
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND/AIMS:The benefits of colonoscopy in reducing colorectal cancer (CRC) risk for patients over 75 years are controversial. We aimed to determine whether colonoscopy use is associated with a decreased risk of CRC in patients 76-85 years old in the United States (US). PATIENTS AND METHODS:All patients in the Med...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000442571
更新日期:2016-01-01 00:00:00
abstract::Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200908
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Weakly acidic reflux has been reported to be the major cause of symptoms in patients with proton pump inhibitor (PPI)-refractory nonerosive reflux disease (NERD) undergoing PPI treatment. We previously reported that reflux at pH 4-5 was the main factor that induced symptoms in such patients. The present st...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000506152
更新日期:2020-02-14 00:00:00
abstract:BACKGROUND AND AIM:Several studies performed in Western countries demonstrate the association between sleep dysfunction and gastroesophageal reflux disease (GERD), especially when nighttime heartburn is present. The purpose of this study was to examine the prevalence and risk factors of sleep dysfunction, and the effec...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000253849
更新日期:2010-01-01 00:00:00
abstract::Electrophoretic studies of inactive ductal pancreatic secretions, collected on five successive days following operation, demonstrated up to 18 protein bands. Comparison of the densitometric scans on the first and fourth days was as follows: the patterns from different individuals appeared similar during the periods of...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197936
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND/AIMS:The pathogenesis of dyspeptic/reflux symptoms and the clinico-pathologic profile of affected patients are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007473
更新日期:1998-01-01 00:00:00
abstract::Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201102
更新日期:1993-01-01 00:00:00
abstract::Proctitis and proctosigmoiditis may be distinct clinical entities. The lesions are restricted to the rectum or extend proximally to involve the sigmoid colon, respectively. Barium enema examination should be normal proximal to the rectum and sigmoid colon. Histology is used merely to confirm the disease process. We pr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201013
更新日期:1993-01-01 00:00:00
abstract::The effects of secretin and caerulein on the absorption of water, sodium, potassium and glucose from the jejunum of dogs were investigated. Intravenous infusion of 1 clinical unit (CU; 82 pmol/kg/h) of secretin inhibited jejunal absorption of water, sodium and glucose compared to control period. Adding an intravenous ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199369
更新日期:1986-01-01 00:00:00
abstract::Patients with moderate-to-severe disease and patients with steroid-refractory or steroid-dependent disease differ in their management, as the latter two groups usually involve patients whose condition is less acute. Systemic corticosteroids represent the mainstay of the management of moderate-to-severe disease and rem...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000111023
更新日期:2007-01-01 00:00:00
abstract::The interactions of adrenergic and cholinergic influences on the gastric D cell were studied using an isolated perfused rat stomach in vitro. The sevenfold increase in the release of somatostatin-like immunoreactivity (SLI) in response to isoproterenol (4 . 10(-8) M) was dose-dependently inhibited by acetylcholine (10...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198817
更新日期:1982-01-01 00:00:00
abstract::Ulcers were produced in the gastric mucosa in rats. After 90 days of healing, one group of animals was given pentagastrin and carbacholine via continuous subcutaneous infusion. After 1 h the animals were killed and the wounds and normal mucosa beside the wounds were prepared for electron microscopy. Stereological anal...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198771
更新日期:1982-01-01 00:00:00
abstract::From questioning 16,939 South African pupils of 16-18 years, in 56 high schools, mean prevalences of appendicectomies in representative segments of ethnic groups were found to be: rural Blacks 0.6%; urban Blacks 0.7%; Indians, 2.9%; Coloureds (Eur-African-Malay), 1.7%; Whites, 10.5%. Percentages in the sexes were simi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198762
更新日期:1982-01-01 00:00:00
abstract::A method of obtaining linear plots of protein-flow data from human pancreatic ductal secretions is described. The protein concentration in pancreatic secretions, when related to flow rates in two individuals, gave similar regression lines, with the correlation coefficients or r = -0.97 and -0.98, respectively, and slo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197922
更新日期:1976-01-01 00:00:00
abstract::The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198068
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Currently, use of the Bravo capsule is a very common method for evaluating the gastroesophageal reflux because it has the advantage of being an intraesophageal catheter-free system. However, endoscopic removal of the capsule is necessary when technical problems or severe discomfort are present. Most frequent...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000194945
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000112646
更新日期:2007-01-01 00:00:00
abstract::Compared with other imaging modalities and clinical investigation, the 111In-pentetreotide scan identified additional metastatic disease sites in 12 carcinoid patients and 2 occult primaries, and influenced the therapeutic outcome in 36 patients [29 carcinoids, 2 atypical carcinoids, 3 cancers of unknown primaries (CU...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201396
更新日期:1996-01-01 00:00:00
abstract::23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly wit...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199198
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS:In patients with active ulcerative colitis (UC), pharmacologics, although initially effective in most patients, are associated with refractoriness, loss of response or unfavourable side effects as additional morbidity factors. Depletion of myeloid lineage leucocytes like the CD14(+)CD16(+) monocyte phen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000479502
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000441352
更新日期:2016-01-01 00:00:00
abstract::A 14C-triolein breath test was carried out on 49 subjects suffering from chronic pancreatitis or from other digestive diseases, and its results were compared with the daily fecal fat excretion. The 14CO2 peak excretion was abnormal in all the subjects with a fecal fat excretion above 14 g/day, whereas individual value...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199015
更新日期:1984-01-01 00:00:00