Abstract:
:This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the villus height. The specific activity of aminopeptidase showed remarkable stability in all conditions. A major stimulation (2.5-fold) was measured for lactase-specific activity. Daily administration of thyroxine completely inhibited the rise of lactase activity. Thyroidectomy caused a significant increase of lactase activity in the orally fed controls, but did not exert any synergistic effect with parenteral nutrition on intestinal enzyme activities. In our experimental conditions intravenous feeding led to a 3-fold decrease in the concentration of thyroid hormones detected in the serum. The results show that total parenteral nutrition leads to a stimulation of the specific activity of brush border lactase in the intestine of adult rat which might be related to the level of thyroid hormones.
journal_name
Digestionjournal_title
Digestionauthors
Raul F,Galluser M,Doffoel Mdoi
10.1159/000199030subject
Has Abstractpub_date
1984-01-01 00:00:00pages
190-6issue
3eissn
0012-2823issn
1421-9867journal_volume
29pub_type
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