Abstract:
:Different materials dissolved in 0.9% NaCl were injected into the connective, interlobular tissue of the duodenal part of the rat pancreas. Activated rat pancreatic juice or trypsin were able to induce localized necrohemorrhagic pancreatitis. Only mild edema and leukocytic infiltration were observed after injecting bovine albumin, chinese ink, trypsinogen or nonactivated pancreatic juice. The progression of histological changes was followed for 2 weeks in the trypsin-induced pancreatitis. Limited foci of severe hemorrhage, liquefaction and coagulative necrosis were observed in the first 24 h. Acinar cell degeneration and regeneration were observed 48 h after the operation, fibroblasts appearing in the interlobular spaces. Four days after injection, inter- and intralobular fibrosis, acinar cell degeneration and tubular complexes were observed, presenting a picture characteristic of chronic pancreatitis. Some minimal changes were still seen in the pancreas 1 week after injection, but by the end of the 2nd week the pancreatic histology was normal. These results demonstrate the significance of active trypsin in the pancreatic interstitium with respect to the induction of pancreatitis. This model of localized necrohemorrhagic pancreatitis is highly reproducible and without significant mortality. Following the acute process, histological changes resembling chronic pancreatitis can be observed, but they are completely reversible.
journal_name
Digestionjournal_title
Digestionauthors
Odaira C,Berger Z,Iovanna JL,Sarles Hdoi
10.1159/000199313subject
Has Abstractpub_date
1986-01-01 00:00:00pages
68-77issue
2eissn
0012-2823issn
1421-9867journal_volume
34pub_type
杂志文章相关文献
DIGESTION文献大全abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200869
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIM:Cutaneous electrical stimulation has been reported to be as effective as electroacupuncture. The aim of this study was to test whether cutaneous electrical stimulation had the same effect as electroacupuncture to enhance the regularity of myoelectrical activity. METHODS:Fifteen healthy male volunteers w...
journal_title:Digestion
pub_type: 临床试验,杂志文章
doi:10.1159/000065596
更新日期:2002-01-01 00:00:00
abstract::From questioning 16,939 South African pupils of 16-18 years, in 56 high schools, mean prevalences of appendicectomies in representative segments of ethnic groups were found to be: rural Blacks 0.6%; urban Blacks 0.7%; Indians, 2.9%; Coloureds (Eur-African-Malay), 1.7%; Whites, 10.5%. Percentages in the sexes were simi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198762
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000507570
更新日期:2020-05-18 00:00:00
abstract:INTRODUCTION:Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. OBJECTIVES:The aim of this study was to establish a novel quantitative meth...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000511851
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND/AIMS:Evaluation of the response of gastroesophageal reflux disease (GERD) symptoms to treatment would be facilitated by a brief, valid, reliable and responsive, self-assessed GERD-sensitive scale. We therefore developed the Reflux Questionnaire (ReQuest). This publication describes the psychometric evaluatio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000079708
更新日期:2004-01-01 00:00:00
abstract::Saliva from one parotid gland was collected under citric acid stimulation in three groups consisting of 69 control subjects and two groups consisting of 25 patients with chronic and relapsing chronic pancreatitis. Mixed saliva was collected under mechanical stimulation from 10 patients and 6 control subjects. Flow rat...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198781
更新日期:1982-01-01 00:00:00
abstract::94 patients with peptic ulcerations of duodenum, stomach, and esophagus, who did not respond to 3 or more months high-dose (450 or 600 mg) treatment with ranitidine, were treated orally with 40 mg omeprazole daily. After healing all patients were offered long-term maintenance therapy with the same dose for 5 years. In...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199610
更新日期:1988-01-01 00:00:00
abstract::Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was ass...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200714
更新日期:1991-01-01 00:00:00
abstract::To assess the sensitivity, specificity and clinical value of prealbumin as liver test, prealbumin plasma levels were measured in 100 patients with liver disease and in 65 patients without clinical evidence of liver impairment. The sensitivity of prealbuminemia was higher than that of albumin, pseudocholinesterase, apo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199471
更新日期:1987-01-01 00:00:00
abstract::This study was conducted to investigate whether chronic kidney disease (CKD) affects intestinal inflammation and intestinal motility and the underlying mechanisms. Rats were randomized into control group and uremic group. Uremia rats were induced by the 5/6 kidney resection, while the control went through the same pro...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000481618
更新日期:2018-01-01 00:00:00
abstract::Carbonic anhydrase (CA) was found to be equally susceptible to direct inhibition by ethanol, whether the enzyme originated from homogenates of rabbit gastric, duodenal, or ileal mucosa. When gastric mucosa was separated into a soluble (cytoplasmic) and a membrane fraction, the membrane CA was more susceptible to ethan...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198130
更新日期:1978-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Capsule endoscopy (CE) has been recognised as an important investigational tool in the diagnosis of gastrointestinal disease. Studies have shown that CE can identify lesions in the upper gastrointestinal tract as well as in the small intestine. However, contrary to conventional oesophagogastroscopy ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000089959
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to exactly determine the pH stability of human gastric lipase (HGL) and to investigate the mechanism underlying the inactivation of HGL which occurs in gastric juice. METHODS:Samples of human gastric juice and purified HGL were incubated at various pH values ranging from 0.5 t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000057708
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND AIM:The medical treatment of rheumatoid arthritis (RA) includes nonsteroidal anti-inflammatory drugs (NSAIDs), low-dose corticosteroids, and disease-modifying antirheumatic drugs (DMARDs). We evaluated the incidence of small bowel injury in RA patients who were taking anti-RA drugs with or without concom...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000190403
更新日期:2008-01-01 00:00:00
abstract::The effects of two synthetic prostaglandin E derivatives on mucus glycoproteins in the stomachs of rats were evaluated. Neither derivative caused change in mucus glycoprotein content in the gastric corpus or antrum, but both increased the biosynthetic activity of mucus glycoproteins in these regions (about 15-30%). Fu...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199621
更新日期:1988-01-01 00:00:00
abstract::Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed rats. The middle third of the crypt was the area stimulated to contribute the ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198579
更新日期:1981-01-01 00:00:00
abstract::Plasma lactate and urate concentrations, following 50 g oral fructose, were compared in 12 control subjects and 13 patients with liver disease. No serious adverse effects occurred following fructose ingestion, and in neither group did the plasma lactate concentration exceed 5.2 mmol/l. There were no significant differ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198843
更新日期:1982-01-01 00:00:00
abstract::Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled. In this study performed on 16 young male subjects, gastric acid secretion and emptying rate were determined after intragastric administration of 8% pep...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200218
更新日期:1990-01-01 00:00:00
abstract::Studies with short-term administration of omeprazole in patients with erosive or ulcerative reflux oesophagitis have demonstrated that strong inhibition of gastric acid secretion will become the therapy of choice for these patients. However, because reflux oesophagitis relapses rapidly when short-term treatment is dis...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200103
更新日期:1989-01-01 00:00:00
abstract::In 1905, John Edkins (1863-1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive pharmacological agents that have revolutionized the management of acid pept...
journal_title:Digestion
pub_type: 传,历史文章,杂志文章
doi:10.1159/000088368
更新日期:2005-01-01 00:00:00
abstract::8 children, known to have been hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive for more than 6 months and with chronic active hepatitis on biopsy, received 2.5 mg levamisole/kg/day, 2 days a week for 6-18 months. In 6 of the 8 children transaminases normalized within 4-18 months of thera...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198821
更新日期:1982-01-01 00:00:00
abstract::The treatment of malignant neuroendocrine gut and pancreatic tumors provides a therapeutic challenge. Surgery as well as medical treatment rarely cure the patient at this stage. Symptoms related to secretory products from the tumor might be life-threatening or at least reduce the quality of life considerably. Interfer...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201204
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The incidence of esophageal cancer is markedly increased in patients with head and neck cancer, and the presence of esophageal cancer is associated with reduced survival rates. AIMS:We investigated whether the results of screening for esophageal cancer in patients with head and neck cancer using chromoendos...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000094523
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:In patients with active ulcerative colitis (UC), pharmacologics, although initially effective in most patients, are associated with refractoriness, loss of response or unfavourable side effects as additional morbidity factors. Depletion of myeloid lineage leucocytes like the CD14(+)CD16(+) monocyte phen...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000479502
更新日期:2017-01-01 00:00:00
abstract::Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200737
更新日期:1991-01-01 00:00:00
abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007815
更新日期:2000-01-01 00:00:00
abstract::Several previous studies have shown that the plasma concentration of gamma-amino-butyric acid (GABA) is markedly increased in patients with hepatic encephalopathy, and it has been suggested that decreased metabolism of peripheral GABA might contribute to the cerebral dysfunctions observed. In the present study, plasma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200724
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND/AIMS:The pathogenesis of dyspeptic/reflux symptoms and the clinico-pathologic profile of affected patients are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007473
更新日期:1998-01-01 00:00:00
abstract::Net fluid movement and mucosal 14C-erythritol clearance were measured in ligated colonic loops of the rat in vivo. The diphenolic laxatives, oxyphenisatin and bisacodyl, dose-dependently inhibited net fluid absorption or caused secretion, both increased the 14C-erythritol clearance. Pretreatment with the adenylate cyc...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199105
更新日期:1984-01-01 00:00:00