Abstract:
:Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fasting for 48 h had reduced villus length but was without effects on the crypts. Refeeding for 6 h of rats fasted for 48 h led to hypertrophic growth: the length of both crypts and villi increased by about 50% without changes in cell number. The uptake of spermidine by the small intestine increased above not only that in fasted rats but also that in the controls fed ad libitum. The high putrescine uptake of rats fasted for 48 h was unchanged after refeeding for 6 h, but returned to control values after 12 h. Spermidine in the gut was well conserved, while most of the putrescine was transformed into non-polyamine metabolites. It is concluded that refeeding stimulates basolateral spermidine uptake, and this may be a general mechanism for polyamine accretion in adaptive growth of the small intestine.
journal_name
Digestionjournal_title
Digestionauthors
Bardócz S,Grant G,Brown DS,Ewen SW,Stewart JC,Pusztai Adoi
10.1159/000200737subject
Has Abstractpub_date
1991-01-01 00:00:00pages
28-35issue
1eissn
0012-2823issn
1421-9867journal_volume
50pub_type
杂志文章相关文献
DIGESTION文献大全abstract:BACKGROUND/AIMS:Gallbladder mucus itself has been recognized to play an important role in gallstone development. Despite the diverse mechanisms of stone induction and the differences in stone composition, there is a quantitative increase in the epithelial mucus production period before stone formation. As brown pigment...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007572
更新日期:1998-11-01 00:00:00
abstract::The luminal mucus layer of the rat's small intestine was separated from the mucosa by filling the lumen with agar jelly. When the rats were fasted overnight and given 59Fe or 65Zn by stomach tube the mucus isolated by this technique contained more isotope and more sialic acid than fed controls, and more of the isotope...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199480
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND/AIMS:This study aimed to analyze the endoscopic mucosal resection (EMR) with a novel uniquely shaped, double-loop snare (Dualoop, Medico's Hirata Inc., Tokyo, Japan) for colorectal polyps. METHODS:This was a clinical trial conducted in two referral centers, Kyoto Prefectural University of Medicine and Natio...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000368044
更新日期:2014-01-01 00:00:00
abstract::Bile salts have been shown to act on lipoprotein-X (LP-X) in vitro to induce a false-negative electrophoretic test. The aim of the present study was to investigate the relationship between serum LP-X and serum bile acids in patients with cholestasis. The in vitro concentration of bile salts required to induce a negati...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198402
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND/AIMS:Pentoxifylline has many anti-inflammatory properties including inhibition of production of tumor necrosis factor alpha (TNF-alpha). Although pentoxifylline prevents several types of gastric mucosal injury, the effect of this drug on ulcer healing is unknown. In this study, we examined the effect of pent...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007752
更新日期:2000-01-01 00:00:00
abstract::An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198094
更新日期:1978-01-01 00:00:00
abstract::We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection technique was used to quantitate mitosis in duodenal crypts at the ulcer edge, giving a regeneration ind...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200987
更新日期:1992-01-01 00:00:00
abstract::D-Galactosamine administration to rats (400 mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and 24 h after D-galactosamine injection. Plasma membrane 5'-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198373
更新日期:1979-01-01 00:00:00
abstract::Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal gr...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200398
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:In this study, a clinical and serological follow-up of 8-10 years was performed in relatives of celiac disease (CD) patients from southern Brazil. The occurrence of new CD cases in the families and the use of two different IgA-tTG enzyme-linked immunosorbent assay (ELISA) kits were also evaluated. METH...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000320451
更新日期:2011-01-01 00:00:00
abstract::Cell renewal in the duodenal mucosa of Mastomys was studied by autoradiography 1 and 24 h after intraperitoneal injection of tritiated thymidine. Non-specific duodenitis and duodenal ulceration were produced with a continuous infusion of histamine. Mucosal renewal in the duodenum of 30 control Mastomys was compared wi...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200226
更新日期:1990-01-01 00:00:00
abstract::Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198335
更新日期:1979-01-01 00:00:00
abstract::This study examined the morphological and functional adaptations occurring in the jejunum of adult rats fed totally by parenteral nutrition during a 4-day period. Comparison was made with sham-operated animals receiving orally a similar isocaloric diet. The intravenously fed rats exhibited a 20% shortening of the vill...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199030
更新日期:1984-01-01 00:00:00
abstract::Previous investigations have demonstrated that the cellular signaling induced by hypoxia-reoxygenation is a major pathway contributing to gastric mucosal injury induced by stress, non-steroidal anti-inflammatory drugs, and Helicobacter pylori. The aim of the present study was to perform a gene expression analysis of t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000094039
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS:In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations we...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007634
更新日期:1999-03-01 00:00:00
abstract::Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197946
更新日期:1976-01-01 00:00:00
abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198344
更新日期:1979-01-01 00:00:00
abstract::The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199280
更新日期:1986-01-01 00:00:00
abstract::We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201406
更新日期:1996-01-01 00:00:00
abstract::Functional changes of the exocrine pancreas in cerulein-induced pancreatitis were evaluated with the isolated perfused rat pancreas. In control specimens (n = 7), baseline pancreatic juice volume was 0.23 +/- 0.06 microliter/min and after stimulation with CCK-8 (10(-10) M) and secretin (10(-10) M), it was 2.26 +/- 0.4...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200879
更新日期:1992-01-01 00:00:00
abstract::A 3 years evolution with amyloid involvement, primarily of the liver, in a patient is described. This led to intrahepatic cholestasis and to portal hypertension with esophageal varices. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198459
更新日期:1980-01-01 00:00:00
abstract::In an attempt to evaluate a possible correlation between cryptogenic chronic liver disease and a present or past hepatitis B virus (HBV) infection, we studied 17 patients with hepatitis B surface antigen (HBsAg)-negative, nonalcoholic chronic liver disease; 9 of them were positive for serum HBsAg detected by a solid-p...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199633
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000288522
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal in...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007805
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Medical therapy of inflammatory bowel disease (IBD) is becoming more complex, given the increasing choice of drugs to treat Crohn's disease (CD) and ulcerative colitis (UC). We aimed to summarize the current guidelines for first-line treatments in IBD. METHODS:An extensive literature search with fo...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000341951
更新日期:2012-01-01 00:00:00
abstract:AIM:To evaluate number and quality of publications in gastroenterology, hepatology and digestive endoscopy from Western Europe (Belgium, Denmark, France, Germany, Great Britain, Italy, the Netherlands, Spain, Sweden, Switzerland), Japan and USA over a recent 5-year period. METHODS:We screened by computer for full live...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007738
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND/AIM:What naturally happens to patients after they undergo conservative and endoscopic treatment of colonic diverticular bleeding (CDB) is largely unknown. We retrospectively track the long-term outcome of the recurrence of CDB between patients with endoscopic and conservative treatment. METHODS:The group wa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000452301
更新日期:2016-01-01 00:00:00
abstract::Daily faecal calcium and magnesium outputs were inversely related to food-stimulated colonic intraluminal pressure in diverticular disease subjects. There was no relationship to sodium potassium and bile acid concentrations, nor to intestinal transit. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198481
更新日期:1980-01-01 00:00:00
abstract::Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient and the provider. The American Society of Anesthesiologists h...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000285504
更新日期:2010-01-01 00:00:00
abstract::Lecithin: cholesterol acyltransferase activity has been measured in serum from patients with various liver disorders and positive LP-X tests and from healthy subjects. Statistical analysis indicated that lecithin: cholesterol acyltransferase activity provided no help in the discrimination between the persons of both g...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198149
更新日期:1978-01-01 00:00:00