Abstract:
:Net fluid movement and mucosal 14C-erythritol clearance were measured in ligated colonic loops of the rat in vivo. The diphenolic laxatives, oxyphenisatin and bisacodyl, dose-dependently inhibited net fluid absorption or caused secretion, both increased the 14C-erythritol clearance. Pretreatment with the adenylate cyclase inhibitor, RMI 12 330 A, did not change these results. It is concluded that diphenolic laxatives mainly influence intestinal fluid transport not by stimulation of mucosal adenylate cyclase but rather by augmenting epithelial permeability.
journal_name
Digestionjournal_title
Digestionauthors
Farack UM,Nell Gdoi
10.1159/000199105subject
Has Abstractpub_date
1984-01-01 00:00:00pages
191-4issue
3eissn
0012-2823issn
1421-9867journal_volume
30pub_type
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