Somatostatin for the prevention of complications following pancreatoduodenectomy.

Abstract:

:Pancreatoduodenectomy (PD) may be followed by serious complications chiefly associated with exocrine pancreatic secretion. Somatostatin and its analogues are able to inhibit pancreatic secretion and thus have been advocated for the prevention of complications following pancreatic surgery. In four published multicentric randomized trials, octreotide administration was associated with a decrease in overall complication rate. However and surprisingly, the benefit is less clear when focusing on complications associated with pancreatic secretion as in pancreatic fistula or in high-risk patients (PD and nonfibrotic pancreas). The efficiency of other somatostatin analogues has not yet been assessed in randomized trials. In conclusion, further studies would be useful before routine prophylactic administration of somatostatin analogues can be recommended.

journal_name

Digestion

journal_title

Digestion

authors

Gouillat C

doi

10.1159/000051490

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

59-63

eissn

0012-2823

issn

1421-9867

pii

dig0c059

journal_volume

60 Suppl 3

pub_type

杂志文章,评审
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  • Acute hepatic failure following transcatheter arterial embolization for the treatment of hepatocellular carcinoma.

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    更新日期:1997-01-01 00:00:00

  • Chest Pain after Endoscopic Submucosal Dissection for Esophageal Cancer: The Simple and Clinically Useful Surrogate Marker for Transmural Thermal Injury by Electrocoagulation.

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    doi:10.1159/000510353

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    pub_type: 杂志文章

    doi:10.1159/000199105

    authors: Farack UM,Nell G

    更新日期:1984-01-01 00:00:00

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    authors: Shimizu N,Watanabe T,Arakawa T,Fujiwara Y,Higuchi K,Kuroki T

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    journal_title:Digestion

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    doi:10.1159/000320451

    authors: Nass FR,Kotze LM,Nisihara RM,de Messias-Reason IJ,Ramos da Rosa Utiyama S

    更新日期:2011-01-01 00:00:00

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    journal_title:Digestion

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    doi:10.1159/000197672

    authors: Caspary WF,Lücke H

    更新日期:1975-01-01 00:00:00

  • Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis.

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    更新日期:2012-01-01 00:00:00

  • Prevalence of minimal change lesions in patients with non-erosive reflux disease: a case-control study.

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    journal_title:Digestion

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    authors: Kim JB,Shin SR,Shin WG,Choi MH,Jang HJ,Kim KO,Park CH,Baek IH,Baik GH,Kim KH,Park SH,Kae SH,Lee MS,Kim HY

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    pub_type: 杂志文章

    doi:10.1159/000199474

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    更新日期:1987-01-01 00:00:00

  • Huge hepatomegaly, jaundice and portal hypertension due to amyloidosis of the liver.

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    doi:10.1159/000198459

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    更新日期:1980-01-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1990-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1159/000502771

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  • Learning Effect of Diagnosing Depth of Invasion Using Non-Extension Sign in Early Gastric Cancer.

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    doi:10.1159/000199389

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    doi:10.1159/000198551

    authors: Cooper BT,Hodgson HJ,Chadwick VS

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