Serological and clinical follow-up of relatives of celiac disease patients from southern Brazil.

Abstract:

BACKGROUND/AIMS:In this study, a clinical and serological follow-up of 8-10 years was performed in relatives of celiac disease (CD) patients from southern Brazil. The occurrence of new CD cases in the families and the use of two different IgA-tTG enzyme-linked immunosorbent assay (ELISA) kits were also evaluated. METHODS:Serum samples of 233 relatives, 186 recruited between 1997 and 2000 (phase I) and 138 between 2006 and 2007 (phase II: 91 of the follow-up group and 47 newly tested), were analyzed. As a comparison group, 100 unrelated healthy individuals were evaluated. IgA-EmA was tested by indirect immunofluorescence and IgA-tTG by ELISA. RESULTS:A significant increase in IgA-EmA/IgA-tTG was detected in relatives of patients with CD when compared to controls (p ≤ 0.001). The positivity of antibodies was higher in females (2.4:1 in phase II; p = 0.039), and its high frequency amongst siblings (∼18.81%) highlights the risk of CD in these individuals. The distribution of antibodies by age suggested that CD can occur at any age in relatives, calling attention to the newly tested relatives >60 years of age (p = 0.0657). A better performance of ELISA kits with human tTG was observed. The confirmation of 13 biopsy-proven new CD cases (5.6%; 13/233) at present points out the predisposition to CD in these individuals and the high specificity of concurrently positive antibodies in relatives, especially when both are present in high titers. CONCLUSION:These results emphasize the familial risk to develop CD and the value of serological screening as an instrument for identifying this disease.

journal_name

Digestion

journal_title

Digestion

authors

Nass FR,Kotze LM,Nisihara RM,de Messias-Reason IJ,Ramos da Rosa Utiyama S

doi

10.1159/000320451

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

89-95

issue

1-2

eissn

0012-2823

issn

1421-9867

pii

000320451

journal_volume

83

pub_type

杂志文章
  • Incorporation of N-acetyl-[14C]D-glucosamine and [3H]L-leucine by isolated pig gastric mucosal cells.

    abstract::Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199889

    authors: Heim HK,Oestmann A,Thiele H,Sewing KF

    更新日期:1989-01-01 00:00:00

  • Induction of gastric ornithine decarboxylase in early weaning rats.

    abstract:BACKGROUND/AIMS:Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach. METHODS:Suckling rats were prematurely weaned on postnatal day 15 and followed through...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051892

    authors: Lin CH,Lyons H,Seelbach MS,Tolia V,Vijesurier R

    更新日期:2001-01-01 00:00:00

  • Gastric cancer development after Helicobacter pylori eradication therapy: a new form of gastric neoplasia.

    abstract:BACKGROUND AND AIM:Along with the widespread use of eradication for Helicobacter pylori (H. pylori), the incidence of gastric cancer after eradication has also been increasing. There is a need for clarification of the clinical and biological characteristics of these neoplasms. PATIENTS AND METHODS:We studied 27 cases ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000335260

    authors: Matsuo T,Ito M,Tatsugami M,Boda T,Takata S,Tanaka S,Chayama K

    更新日期:2012-01-01 00:00:00

  • Terminal-restriction fragment length polymorphism (T-RFLP) analysis for changes in the gut microbiota profiles of indomethacin- and rebamipide-treated mice.

    abstract:BACKGROUND/AIMS:We investigated the effects of indomethacin and rebamipide on the gut microbiota profiles using terminal restriction fragment polymorphism (T-RFLP) analysis. MATERIALS AND METHODS:Female C57BL/6J mice were given indomethacin (10 mg/kg, s.c.) once a day and 2.5 mg rebamipide orally 3 times a day. After ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000341508

    authors: Imaeda H,Fujimoto T,Takahashi K,Kasumi E,Fujiyama Y,Andoh A

    更新日期:2012-01-01 00:00:00

  • Conscious Sedation Using Midazolam and Sequential Flumazenil in Cirrhotic Patients for Prophylactic Endoscopic Variceal Ligation.

    abstract:BACKGROUND/AIMS:This study investigated the safety of endoscopic variceal ligation (EVL) under conscious sedation with midazolam and sequential flumazenil after procedure in these patients. METHODS:A total of 279 patients who underwent secondary prophylactic EVL at our institution between April 2012 and June 2014, wer...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000440715

    authors: Kim SI,Jin YJ,Lee SH,Lee JW,Lee DH,Lee D

    更新日期:2015-01-01 00:00:00

  • Argyrophil cell hyperplasia of fundic mucosa in patients with chronic atrophic gastritis.

    abstract::Eighteen cases of severe hyperplasia of fundic argyrophil cells observed during routine histologic examination of endoscopic gastric biopsy specimens from unselected patients with upper gastro-intestinal symptomatology were investigated. All patients, except one, were female with a mean age of 57 years. Atrophic gastr...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199389

    authors: Bordi C,Pilato F,Carfagna G,Ferrari C,D'Adda T,Sivelli R,Bertelé A,Missale G

    更新日期:1986-01-01 00:00:00

  • Pharmacodynamic effects of Sandostatin in the gastrointestinal tract.

    abstract::Somatostatin is widely distributed throughout the human gastrointestinal system. There it is found in neurons and fibers of both the submucosal and the myenteric plexus and the pancreas as well as in the D cells of the stomach, gut and pancreatic islets. Whereas in the intestinal nervous system, in the duodenum and th...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201070

    authors: Gyr KE,Meier R

    更新日期:1993-01-01 00:00:00

  • Gastric cytoprotection by acetazolamide: role of endogenous prostaglandins.

    abstract::This study was designed to determine the influence of acetazolamide, a potent inhibitor of carbonic anhydrase, on the formation of gastric mucosal lesions induced by acidified aspirin (ASA) or absolute ethanol and on gastric cytoprotection induced by prostaglandin E2 (PGE2). Acetazolamide prevented dose-dependently et...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198975

    authors: Konturek SJ,Brzozowski T,Piastucki I,Radecki T

    更新日期:1983-01-01 00:00:00

  • Gastric carcinoid with histamine production, histamine transporter and expression of somatostatin receptors.

    abstract::A case of sporadic, histamine-producing gastric carcinoid with liver metastases is reported. The patient was treated with somatostatin analogue (octreotide) combined with cortisone and blockade of histamine receptors prior to surgery, which included subtotal gastrectomy, excision of lymph node metastases and superfici...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007482

    authors: Kölby L,Wängberg B,Ahlman H,Jansson S,Forssell-Aronsson E,Erickson JD,Nilsson O

    更新日期:1998-01-01 00:00:00

  • Role of the ileocecal valve and site of intestinal resection in malabsorption after extensive small bowel resection.

    abstract::Intestinal absorption after extensive small bowel resections, for diseases other than Crohn's disease, was studied in 17 patients. When the ileocecal valve and the right colon were preserved, malabsorption was transient and moderate and had no prejudicial nutritional effect (fecal fat: 8.8 +/- 1.8 g/24 h in resections...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198220

    authors: Cosnes J,Gendre JP,Le Quintrec Y

    更新日期:1978-01-01 00:00:00

  • Apparent post-transcriptional modification of ornithine decarboxylase accounts for its induction in IEC-6 cells in culture.

    abstract::Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200412

    authors: Seidel ER,Ginty DD

    更新日期:1990-01-01 00:00:00

  • Lactulose is highly potential in prophylaxis of hepatic encephalopathy in patients with cirrhosis and upper gastrointestinal bleeding: results of a controlled randomized trial.

    abstract:BACKGROUND AND AIMS:Upper gastrointestinal bleeding (UGB) is an important precipitating factor for the development of hepatic encephalopathy (HE) in cirrhotic patients. The aim of this study was to evaluate the efficacy of lactulose in a controlled randomized trial for prophylaxis of HE after UGB. PATIENTS AND METHODS...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000346083

    authors: Wen J,Liu Q,Song J,Tong M,Peng L,Liang H

    更新日期:2013-01-01 00:00:00

  • Reduced expression of epidermal growth factor receptor-related protein in hepatocellular carcinoma: implications for cancer growth.

    abstract:BACKGROUND/AIMS:The mitogenic signaling pathway of epidermal growth factor receptor (EGFR) is activated in a variety of cancers, including hepatocellular carcinoma (HCC). The recently cloned EGFR-related protein (ERRP) has been proposed to be a negative regulator of EGFR. The expression of ERRP in non-malignant liver c...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000079151

    authors: Moon WS,Chang KJ,Majumdar AP,Tarnawski AS

    更新日期:2004-01-01 00:00:00

  • Clinical, controlled trial of somatostatin with ranitidine and placebo in the control of peptic hemorrhage of the upper gastrointestinal tract.

    abstract::There are many controversies concerning the treatment of hemorrhages of the upper gastrointestinal tract. In order to determine whether some currently used drugs, such as somatostatin (SST) and ranitidine, may be useful in the control of hemorrhages, we have conducted a controlled (not blind) study with alternate assi...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199876

    authors: Coraggio F,Bertini G,Catalano A,Scarpato P,Gualdieri L

    更新日期:1989-01-01 00:00:00

  • Incidence of inflammatory bowel disease in southeastern Norway: evaluation of methods after 1 year of registration. Southeastern Norway IBD Study Group of Gastroenterologists.

    abstract::To assess the feasibility of a prospective incidence study of inflammatory bowel disease (IBD), the registration methods and incidence figures during 1990 were evaluated. The study was a collaboration between 14 hospitals in an area of close to one million inhabitants. Common diagnostic criteria for ulcerative colitis...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201262

    authors: Moum B,Vatn MH,Ekbom A,Fausa O,Aadland E,Lygren I,Sauar J,Schulz T

    更新日期:1995-01-01 00:00:00

  • Severe and steroid-resistant Crohn's disease.

    abstract::Patients with moderate-to-severe disease and patients with steroid-refractory or steroid-dependent disease differ in their management, as the latter two groups usually involve patients whose condition is less acute. Systemic corticosteroids represent the mainstay of the management of moderate-to-severe disease and rem...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000111023

    authors: Michetti P,Mottet C,Juillerat P,Pittet V,Felley C,Vader JP,Gonvers JJ,Froehlich F

    更新日期:2007-01-01 00:00:00

  • Aldolase isoenzymes in liver cirrhosis and primary liver cell cancer.

    abstract::The isoenzymatic pattern of aldolase was determined by immunoprecipitation with specific anti-aldolase A, B and C sera in 21 pathological liver tissues and in the sera of normals (n equals 20), liver cirrhotics (n equals 52) and hepatoma patients (n equals 22). The increase of aldolase A in primary liver cell carcinom...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197663

    authors: Lehmann FG,Kornacher J

    更新日期:1975-01-01 00:00:00

  • Establishment and characterization of two new rectal neuroendocrine cell carcinoma cell lines.

    abstract:BACKGROUND:Human colorectal neuroendocrine cell carcinoma (NEC) is a rare disease with a poor prognosis. The biological behavior of NEC remains poorly understood. MATERIALS AND METHODS:We established two new NEC cell lines from a patient with rectal neuroendocrine carcinoma, NECS-P and NECS-L from the primary tumor an...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007825

    authors: Takahashi Y,Onda M,Tanaka N,Seya T

    更新日期:2000-01-01 00:00:00

  • Edkins and a century of acid suppression.

    abstract::In 1905, John Edkins (1863-1940) undertook the studies of gastrin that have subsequently formed the basis for a century of investigation into the physiological basis of acid secretion and led to the elucidation of a variety of acid-suppressive pharmacological agents that have revolutionized the management of acid pept...

    journal_title:Digestion

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000088368

    authors: Modlin IM,Sachs G,Wright N,Kidd M

    更新日期:2005-01-01 00:00:00

  • Advances in the Treatment of Cholinergic Anti-Inflammatory Pathways in Gastrointestinal Diseases by Electrical Stimulation of Vagus Nerve.

    abstract:BACKGROUND:The cholinergic anti-inflammatory pathway (CAIP) has been proposed as a key mechanism by which the brain, through the vagus nerve (VN), modulates the immune system in the body. Recent studies of VN stimulation (VNS) in vivo systems have shown that it plays an anti-inflammatory role through CAIP. Inflammatory...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000504474

    authors: Lei W,Duan Z

    更新日期:2019-11-29 00:00:00

  • Effects of n-3 polyunsaturated fatty acids and vitamin E on colonic mucosal leukotriene generation, lipid peroxidation, and microcirculation in rats with experimental colitis.

    abstract:AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051872

    authors: Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

    更新日期:2001-01-01 00:00:00

  • Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine.

    abstract:BACKGROUND/AIMS:L-glutamine (L-gln) is a conditionally essential amino acid which is consumed by certain tissues like the intestine in large amounts as energy source during critical illness. Apart from nutritive action, recent data suggest a link to heat-shock protein (hsp) induction. We investigated the effect of L-gl...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000048844

    authors: Lindemann G,Grohs M,Stange EF,Fellermann K

    更新日期:2001-01-01 00:00:00

  • Argon plasma coagulation of gastric inlet patches for the treatment of globus sensation: it is an effective therapy in the long term.

    abstract:AIM:To determine the long-term effect of argon plasma coagulation (APC) of gastric inlet patches in the cervical esophagus for patients suffering from globus sensation. METHODS:We intended to follow up all patients between 2004 and 2011 (n = 49) who received argon plasma ablation of gastric inlet patches for globus se...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000355274

    authors: Klare P,Meining A,von Delius S,Wolf P,Konukiewitz B,Schmid RM,Bajbouj M

    更新日期:2013-01-01 00:00:00

  • The gastric acid secretagogue gastrin-releasing peptide and the inhibitor oxyntomodulin do not exert their effect directly on the parietal cell in the rat.

    abstract::Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [1...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199648

    authors: Gehl J,Jeppesen JL,Poulsen SS,Holst JJ

    更新日期:1988-01-01 00:00:00

  • Pain in the Early Phase of Pediatric Pancreatitis (PINEAPPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial.

    abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000441352

    authors: Zsoldos F,Párniczky A,Mosztbacher D,Tóth A,Lásztity N,Hegyi P,Hungarian Pancreatic Study Group and the International Association of Pancreatology.

    更新日期:2016-01-01 00:00:00

  • Mechanism of action of diphenolic laxatives: the role of adenylate cyclase and mucosal permeability.

    abstract::Net fluid movement and mucosal 14C-erythritol clearance were measured in ligated colonic loops of the rat in vivo. The diphenolic laxatives, oxyphenisatin and bisacodyl, dose-dependently inhibited net fluid absorption or caused secretion, both increased the 14C-erythritol clearance. Pretreatment with the adenylate cyc...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199105

    authors: Farack UM,Nell G

    更新日期:1984-01-01 00:00:00

  • Critical flicker frequency as a marker of hepatic encephalopathy in patients before and after transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000288522

    authors: Biecker E,Hausdörfer I,Grünhage F,Strunk H,Sauerbruch T

    更新日期:2011-01-01 00:00:00

  • Optimizing symptom relief and preventing complications in adults with gastro-oesophageal reflux disease.

    abstract::Gastro-oesophageal reflux disease (GORD) is a chronic illness causing recurrent typical and atypical symptoms. Possible complications include oesophagitis, ulcer, stricture and Barrett's oesophagus. Evidence suggests that the intraoesophageal pH correlates directly with the degree of mucosal injury. Proton pump inhibi...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000076371

    authors: Savarino V,Dulbecco P

    更新日期:2004-01-01 00:00:00

  • Glutamine Blocks Interleukin-13-Induced Intestinal Epithelial Barrier Dysfunction.

    abstract:INTRODUCTION:Impaired intestinal epithelial barrier function is a hallmark of a variety of pathological conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). IBD patients with IBS-like symptoms show higher interleukin-13 (IL-13) serum levels and poor psychological well-being. Supplemen...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000502953

    authors: Li M,Oshima T,Ito C,Yamada M,Tomita T,Fukui H,Miwa H

    更新日期:2019-09-18 00:00:00

  • Effect of the somatostatin analogue sandostatin (SMS 201-995) on gastrointestinal, pancreatic and biliary function and hormone release in normal men.

    abstract::The effect of the long-acting somatostatin analogue Sandostatin (SMS 201-995) on intestinal absorption and propagation (mouth-to-caecum transit time; MCTT), on pancreatic secretion and on gall bladder contraction after direct (secretin-pancreozymin test) and indirect stimulation (Lundh meal), and on meal-induced respo...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199408

    authors: Lembcke B,Creutzfeldt W,Schleser S,Ebert R,Shaw C,Koop I

    更新日期:1987-01-01 00:00:00