Abstract:
:Previous studies suggested that gastrin-releasing peptide (a neuropeptide found in rat oxyntic mucosa) and oxyntomodulin (a glucagon-containing peptide of mammalian gut) could directly affect the acid secretion of the parietal cells. We therefore studied their effect on gastric acid production in vitro by measuring [14C]-aminopyrine accumulation, a reliable index of H+ generation, in isolated rat parietal cells. However, neither gastrin-releasing peptide nor oxyntomodulin influenced basal acid secretion or histamine-stimulated gastric acid secretion. Electron-microscopic studies of unstimulated and histamine-stimulated parietal cells confirmed that the cells retained the normal morphology of intracellular organelles and that the cells responded to physiological stimulation by marked expansion of the intracellular canaliculi.
journal_name
Digestionjournal_title
Digestionauthors
Gehl J,Jeppesen JL,Poulsen SS,Holst JJdoi
10.1159/000199648subject
Has Abstractpub_date
1988-01-01 00:00:00pages
144-51issue
3eissn
0012-2823issn
1421-9867journal_volume
40pub_type
杂志文章相关文献
DIGESTION文献大全abstract::Outpatient treatment of haemorrhoids by elastic band ligation without anaesthetic was performed in 75 patients. Clinical review showed that 65 returned to work within 24 h of ligation, 8 in 48 h and 2 after 48 h. No patient required hospitalisation for either rectal bleeding or pain after ligation. In the first week a...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197658
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM:To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS:Prepubertal children of ages 3-12 with either la...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000381895
更新日期:2015-01-01 00:00:00
abstract::After two decades of progress the best current approach to treatment of Helicobacter pylori infection is a strategy that combines two consecutive complementary treatments. Current guidelines recommend a first-line triple therapy - 7-10 days of a proton-pump inhibitor (PPI), clarithromycin and amoxicillin - followed by...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000089787
更新日期:2006-01-01 00:00:00
abstract::The interactions of adrenergic and cholinergic influences on the gastric D cell were studied using an isolated perfused rat stomach in vitro. The sevenfold increase in the release of somatostatin-like immunoreactivity (SLI) in response to isoproterenol (4 . 10(-8) M) was dose-dependently inhibited by acetylcholine (10...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198817
更新日期:1982-01-01 00:00:00
abstract::The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199492
更新日期:1987-01-01 00:00:00
abstract::We studied the functional coupling between antral somatostatin and gastrin cells in pigs using isolated perfused preparations of the antrum with intact supply of the vagus nerves. Luminal acidification significantly inhibited gastrin secretion to 61 +/- 3% of basal secretion and increased somatostatin output 9-fold. I...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200882
更新日期:1992-01-01 00:00:00
abstract::The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000200231
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Few prospective population-based studies have been carried out on the incidence of inflammatory bowel disease (IBD). In a population-based study of pediatric IBD in southeastern Norway, patients <16 years at the time of diagnosis were followed up prospectively. The study reports on changes in diagnosis and c...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000082893
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Cytomegalovirus (CMV) infection exacerbates ulcerative colitis (UC) refractory to immunosuppressive therapies (IMT). However, the underlying UC remained active in some UC patients, despite the fact that CMV-DNA in colonic mucosa became negative after antiviral therapy. Therefore, new therapeutic strategies f...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000321911
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Endoscopic submucosal dissection (ESD) of early esophageal cancer (EC) is becoming more widespread. Post-ESD coagulation syndrome (CS) has been proposed as temporary inflammatory signs that occur during the post-ESD period caused by transmural thermal injury by electrocoagulation. This retrospective study ai...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000510353
更新日期:2020-10-08 00:00:00
abstract::This study was undertaken to evaluate the effect of metoclopramide on transmural oesophageal variceal pressure and portal blood flow in cirrhotic patients. Sixteen cirrhotics were randomly assigned to metoclopramide (10 mg i.v.) or saline. Metoclopramide significantly decreased transmural variceal pressure (15.7% decr...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000200477
更新日期:1990-01-01 00:00:00
abstract::A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007815
更新日期:2000-01-01 00:00:00
abstract::Different materials dissolved in 0.9% NaCl were injected into the connective, interlobular tissue of the duodenal part of the rat pancreas. Activated rat pancreatic juice or trypsin were able to induce localized necrohemorrhagic pancreatitis. Only mild edema and leukocytic infiltration were observed after injecting bo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199313
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIM:Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000110684
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Gut microbiota affects host homeostasis and dysbiosis causes host diseases. Therefore, uncovering the sensing mechanism of bacterial metabolites such as short-chain fatty acid (SCFA) may help us to understand the host-microbiota interaction both in physiological and nonphysiological conditions. SUMMARY:The ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000356211
更新日期:2014-01-01 00:00:00
abstract::There is no generally accepted treatment in the irritable bowel syndrome (IBS), probably because of a lack of convincing therapeutic trials. In the present study, 120 outpatients with IBS participated in a prospective randomized therapeutic trial. According to a double-blind design, 40 patients received 400 mg/day meb...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000199329
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND/AIMS:In this study, a clinical and serological follow-up of 8-10 years was performed in relatives of celiac disease (CD) patients from southern Brazil. The occurrence of new CD cases in the families and the use of two different IgA-tTG enzyme-linked immunosorbent assay (ELISA) kits were also evaluated. METH...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000320451
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND AND AIM:Along with the widespread use of eradication for Helicobacter pylori (H. pylori), the incidence of gastric cancer after eradication has also been increasing. There is a need for clarification of the clinical and biological characteristics of these neoplasms. PATIENTS AND METHODS:We studied 27 cases ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000335260
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000064935
更新日期:2002-01-01 00:00:00
abstract::D-Galactosamine administration to rats (400 mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and 24 h after D-galactosamine injection. Plasma membrane 5'-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition w...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198373
更新日期:1979-01-01 00:00:00
abstract:INTRODUCTION:Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. OBJECTIVES:The aim of this study was to establish a novel quantitative meth...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000511851
更新日期:2020-12-01 00:00:00
abstract::Ulcers were produced in the gastric mucosa in rats. After 90 days of healing, one group of animals was given pentagastrin and carbacholine via continuous subcutaneous infusion. After 1 h the animals were killed and the wounds and normal mucosa beside the wounds were prepared for electron microscopy. Stereological anal...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198771
更新日期:1982-01-01 00:00:00
abstract::L-Amino acid solution given intravenously in Heidenhain pouch dogs resulted in marked changes of both basal and pentagastrin-stimulated gastric secretions. During a 1-hour amino acid infusion, a significant augmentation of pentagastrin-induced secretion was observed. A significant increase of secretion during amino ac...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198207
更新日期:1978-01-01 00:00:00
abstract::We have previously shown a specific significant overexpression in the exocrine pancreatic tissue of two members of the regenerating gene multifamily: reg I and reg II in the non-obese diabetic (NOD) mouse during active diabetogenesis. To strengthen the hypothesis that the overexpression of these genes may represent a ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000048867
更新日期:2001-01-01 00:00:00
abstract::Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200908
更新日期:1992-01-01 00:00:00
abstract::Functional changes of the exocrine pancreas in cerulein-induced pancreatitis were evaluated with the isolated perfused rat pancreas. In control specimens (n = 7), baseline pancreatic juice volume was 0.23 +/- 0.06 microliter/min and after stimulation with CCK-8 (10(-10) M) and secretin (10(-10) M), it was 2.26 +/- 0.4...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200879
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Combinations of antitumor necrosis factor alpha (TNFα) and immunomodulators may be indicated in high-risk inflammatory bowel disease patients. Our aims were to compare disease course between children that did and did not step down to anti-TNFα monotherapy and to define risk factors for complicated disease cou...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000496273
更新日期:2020-01-01 00:00:00
abstract::The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. During the active phase of the disease, the NO3 excretion was significantly higher in the patients than in healthy controls (n = 6, p < 0....
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201332
更新日期:1996-01-01 00:00:00
abstract::Non-erosive reflux disease (NERD) has assumed increasing prominence in studies of gastroesophageal reflux disease (GERD), but it remains a challenge to define NERD precisely and to define its place in the investigation and treatment of GERD. Most simply, NERD may be defined as GERD in an individual who has no evidence...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000151255
更新日期:2008-01-01 00:00:00
abstract::Net fluid movement and mucosal 14C-erythritol clearance were measured in ligated colonic loops of the rat in vivo. The diphenolic laxatives, oxyphenisatin and bisacodyl, dose-dependently inhibited net fluid absorption or caused secretion, both increased the 14C-erythritol clearance. Pretreatment with the adenylate cyc...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199105
更新日期:1984-01-01 00:00:00