Huge hepatomegaly, jaundice and portal hypertension due to amyloidosis of the liver.

abstract：BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...

journal_title：Digestion

authors： Konturek PC,Jaworek J,Maniatoglou A,Bonior J,Meixner H,Konturek SJ,Hahn EG

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) is a standard treatment for tumors of the gastrointestinal tract. We developed a self-completion method of ESD using Endosaber to eliminate the need for an additional device or human assistance during the procedure. The aim of this study was to evaluate the technical fe...

journal_title：Digestion

authors： Esaki M,Minoda Y,Wada M,Sakisaka S,Tsuruta S,Hosokawa T,Matsuguchi T,Ichijima R,Suzuki S,Tamura Y,Iwao A,Yamakawa S,Irie A,Ihara E,Ogawa Y

更新日期：2019-09-27 00:00:00

abstract：BACKGROUND/AIMS:Grading gastric mucosal atrophy in antrum biopsy specimens remains a controversial subject because of limitations in interobserver agreement. We previously described a reliable, quantitative method for grading atrophy of the corpus mucosa with excellent reproducibility and good correlation with the Sydn...

journal_title：Digestion

authors： van Grieken NC,Meijer GA,Kale I,Bloemena E,Lindeman J,Offerhaus GJ,Meuwissen SG,Baak JP,Kuipers EJ

更新日期：2004-01-01 00:00:00

abstract：:Leucine absorption across the mechanically obstructed rat intestine was studied by in vivo and in vitro techniques. It varied between the early (after 2 h) and late (after 18 h) phases of the obstruction. During the early phase there was a reduction in mucosal uptake and in net absorption of the amino acid. At 18 h th...

journal_title：Digestion

authors： Hajjar JJ,Schwartz RG,Mirkin KR,Tomicic TK

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. ...

journal_title：Digestion

authors： Krug S,Michl P

更新日期：2017-01-01 00:00:00

abstract：:Malabsorption syndromes are commonly caused by pathological interferences of normal digestive processes. In the last several years major advances in the diagnosis and treatment of these syndromes has emerged. This review will focus on diseases in which the mucosal phase of the digestive process is predominately distur...

journal_title：Digestion

authors： Sun DF,Fang JY

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The gut-liver-axis presents the pathophysiological hallmark for multiple liver diseases and has been proposed to be modulated during stress and shock. Access to the gut-liver-axis needs crossing of the mucus and gut-vascular barrier. The role of β-adrenoreceptor-activation for both barriers has not been defi...

journal_title：Digestion

authors： Sorribas M,de Gottardi A,Moghadamrad S,Hassan M,Spadoni I,Rescigno M,Wiest R

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Colorectal cancer (CRC) patients are at high risk for developing extracolorectal malignancies (EMs). Although development of a second primary cancer and deaths thereof are included as events of disease-free survival (DFS) and overall survival (OS), the role of EMs in these survival end points has not be...

journal_title：Digestion

authors： Kawai K,Ishihara S,Nozawa H,Hata K,Kiyomatsu T,Tanaka T,Nishikawa T,Otani K,Yasuda K,Murono K,Sasaki K,Watanabe T

更新日期：2016-01-01 00:00:00

abstract：:The pancreatic exocrine secretory response to increasing doses of exogenous caerulein with and without a background infusion of secretin was studied in 5 healthy volunteers. Caerulein over a full range of doses (2.3-37 pmol/kg/h) produced increasing enzyme secretion up to 18.5 pmol/kg/h, whereas 37 pmol/kg/h was clear...

journal_title：Digestion

authors： Beglinger C,Köhler E,Stalder GA,Jansen J,Gyr K

更新日期：1986-01-01 00:00:00

abstract：:The effects of two recently developed gastrin receptor antagonists, PD 136450 and L-365,260, on pentagastrin-stimulated acid secretion were investigated in rats. PD 136450 at a dose of 6 mg/kg s.c. (9.6 mumol) completely abolished acid secretion induced by pentagastrin. The inhibition of 18 mg/kg PD 136450 s.c. lasted...

journal_title：Digestion

authors： Eissele R,Koop H,Bothe-Sandfort E,Arnold R

更新日期：1992-01-01 00:00:00

abstract：:Several previous studies have shown that the plasma concentration of gamma-amino-butyric acid (GABA) is markedly increased in patients with hepatic encephalopathy, and it has been suggested that decreased metabolism of peripheral GABA might contribute to the cerebral dysfunctions observed. In the present study, plasma...

journal_title：Digestion

authors： Löscher W,Kretz FJ,Karavias T,Dillinger U

更新日期：1991-01-01 00:00:00

abstract：:Fragments of benign colonic adenomatous polyps of man, adenocarcinoma of the colon of man, and normal colonic mucosa of man and rodent were transplanted under the kidney capsule of athymic mice. Benign human adenomatous cells survived for periods of up to 28 days, normal rodent colonic epithelial cells for 45 days and...

journal_title：Digestion

authors： Bhargava DK,Lipkin M

更新日期：1981-01-01 00:00:00

abstract：:This study evaluated the effect of a cellulose meal and a cellulose-oleic acid meal on gastroduodenal motility and gastric emptying. The cellulose meal produced a high antral motility index (100 +/- 34 V/10 min) and a high proportion (80.2%) of propulsive duodenal contractions. The oleic acid meal was associated with ...

journal_title：Digestion

authors： Schemann M,Ehrlein HJ

更新日期：1982-01-01 00:00:00

abstract：:Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restric...

journal_title：Digestion

authors： Miller DL,Schedl HP,Bouska J,Phillips SF

更新日期：1987-01-01 00:00:00

abstract：:One to four months after implantation of a gastric fistula, a circadian rhythm in gastric acidity could be demonstrated by use of the intragastric 24-hour pH-metry in dogs with the gastric fistula protruding on the left side of the upper abdomen. This circadian rhythm was found to be fully developed within 3 years, an...

journal_title：Digestion

authors： Postius S,Bräuer U

更新日期：1995-01-01 00:00:00

abstract：:The clinical relevance of cispride's stimulating effects on lower oesophageal motility was studied in 19 patients with documented (endoscopy, biopsy) grade II or III oesophagitis. Patients were treated for 8 or 16 weeks (depending essentially on whether the result was cure or failure) with 10 mg of cisapride four time...

journal_title：Digestion

authors： Lepoutre L,Van der Spek P,Vanderlinden I,Bollen J,Laukens P

更新日期：1990-01-01 00:00:00

abstract：:Recent studies have demonstrated the presence of both CCKA and CCKB receptors on dog and guinea pig pancreas. Although CCKA receptors are implicated in enzymatic secretion, biological effects of CCKB receptors are still unknown. We have previously found that a rat acinar pancreatic cell line (AR4-2J) possesses both re...

journal_title：Digestion

authors： Seva C,De Vries L,Scemama JL,Sarfati P,Nicolet TG,Pradayrol L,Vaysse N

更新日期：1990-01-01 00:00:00

abstract：:The healing of acetic acid-induced gastric and duodenal ulcers was examined together with the biochemical indices of growth in gastric and duodenal mucosa in the following three groups of rats: (a) chow-fed, (b) fed an isocaloric liquid diet, (c) fed the liquid diet plus pentagastrin injections (250 micrograms/kg, 3 t...

journal_title：Digestion

authors： Takeuchi K,Johnson LR

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND/AIMS:Pentoxifylline has many anti-inflammatory properties including inhibition of production of tumor necrosis factor alpha (TNF-alpha). Although pentoxifylline prevents several types of gastric mucosal injury, the effect of this drug on ulcer healing is unknown. In this study, we examined the effect of pent...

journal_title：Digestion

authors： Shimizu N,Watanabe T,Arakawa T,Fujiwara Y,Higuchi K,Kuroki T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:The pathogenesis of dyspeptic/reflux symptoms and the clinico-pathologic profile of affected patients are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa i...

journal_title：Digestion

authors： Villani L,Trespi E,Fiocca R,Broglia F,Colla C,Luinetti O,Tinelli C,Solcia E

更新日期：1998-01-01 00:00:00

abstract：:An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeo...

journal_title：Digestion

authors： Pennington CR,Ross PE,Bouchier IA

更新日期：1978-01-01 00:00:00

abstract：:The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...

journal_title：Digestion

authors： Meyer T,Brinck U

更新日期：1999-01-01 00:00:00

abstract：:Hepatitis B surface antigen (HBsAg)-associated receptors for polymerized human serum albumin (RpHSA) are assumed to mediate viral attachment to hepatocytes in hepatitis B virus (HBV) infection. RpHSA was found to be coded by the pre-S region of HBV genome. Recently, the antiviral effect of recombinant leukocyte alpha-...

journal_title：Digestion

authors： Gerken G,Manns M,Hess G,Meyer zum Büschenfelde KH

更新日期：1987-01-01 00:00:00

abstract：:Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, ...

journal_title：Digestion

authors： Simon B,Kather H

更新日期：1977-01-01 00:00:00

abstract：:A young Indian man presented in England with a 6-month history of diarrhoea which started just before leaving India. He was found to have tropical enteropathy and H. nana infestation, but while the infestation and symptoms disappeared with antihelminthic treatment, the tropical enteropathy persisted. Hymenolepiasis is...

journal_title：Digestion

authors： Cooper BT,Hodgson HJ,Chadwick VS

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate genotyping for two DNA variants (c.1993+327C>T and c.1438+117G>A), recently found to be associated with adult-type hypolactasia, in the diagnosis of lactose intolerance. METHODS:In total, 166 consecutive patients with gastrointestinal symptoms mimicking hypolactasia admitted to the clin...

journal_title：Digestion

authors： Büning C,Genschel J,Jurga J,Fiedler T,Voderholzer W,Fiedler EM,Worm M,Weltrich R,Lochs H,Schmidt H,Ockenga J

更新日期：2005-01-01 00:00:00

abstract：:A case of sporadic, histamine-producing gastric carcinoid with liver metastases is reported. The patient was treated with somatostatin analogue (octreotide) combined with cortisone and blockade of histamine receptors prior to surgery, which included subtotal gastrectomy, excision of lymph node metastases and superfici...

journal_title：Digestion

authors： Kölby L,Wängberg B,Ahlman H,Jansson S,Forssell-Aronsson E,Erickson JD,Nilsson O

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate whether the neuronal form of nitric oxide (NO) synthase (nNOS) in gastric mucosa differed from nNOS in the brain in subcellular distribution or antigenicity, and to determine the relative activity of the endothelial form of NO synthase (eNOS) and nNOS in gastric mucosa. METHODS:Subcellul...

journal_title：Digestion

authors： Price K,Hanson P

更新日期：1998-07-01 00:00:00

abstract：:Carbonic anhydrase (CA) was found to be equally susceptible to direct inhibition by ethanol, whether the enzyme originated from homogenates of rabbit gastric, duodenal, or ileal mucosa. When gastric mucosa was separated into a soluble (cytoplasmic) and a membrane fraction, the membrane CA was more susceptible to ethan...

journal_title：Digestion

authors： Newsome LR,Leitch GJ

更新日期：1978-07-01 00:00:00

abstract：:Electrophoretic studies of inactive ductal pancreatic secretions, collected on five successive days following operation, demonstrated up to 18 protein bands. Comparison of the densitometric scans on the first and fourth days was as follows: the patterns from different individuals appeared similar during the periods of...

journal_title：Digestion

authors： Allan BJ,White TT

更新日期：1976-01-01 00:00:00