Food restriction and recovery of nonabsorbed indicators from the small intestine of the rat.

Abstract:

:Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restriction (50%) and fasting on recovery of indicators perfused intraluminally through the entire small intestine. Recovery of PEG 4000 and phenol red was essentially complete (98-100%) from control and restricted groups, but was 96% from the fasted group. PEG 400, consisting of a homologous series of polymers of which seven were measured (MW 242-506), was also perfused. The lower-molecular-weight polymers were absorbed. Absorption decreased with increasing molecular weight, and the slope of the relation of absorption to molecular weight was the same for all groups.

journal_name

Digestion

journal_title

Digestion

authors

Miller DL,Schedl HP,Bouska J,Phillips SF

doi

10.1159/000199576

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

83-9

issue

2

eissn

0012-2823

issn

1421-9867

journal_volume

38

pub_type

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