Double-Filtration Plasmapheresis plus Interferon-β for HCV-1b Patients with Non-Sustained Virological Response to Previous Combination Therapy.

Abstract:

BACKGROUND AND AIMS:Double-filtration plasmapheresis (DFPP) together with interferon (IFN) administration produces a substantial reduction in the viral load during the early stages of treatment. METHODS:Based on their responses to previous pegylated IFN and ribavirin (PEG-IFN/RBV) therapy, 20 patients were divided into null virological response (NVR; n = 12) and relapse (n = 8) groups. DFPP was used in combination with IFN-β/RBV with subsequent administration of PEG-IFN-α2a/RBV therapy (DFPP + IFN-β/RBV then PEG-IFN/RBV). Early viral dynamics was assessed, focusing especially on complete early virological response (cEVR) associated with sustained virological response. Additionally, the interleukin 28B gene, the IFN/RBV resistance-determining region, the IFN sensitivity-determining region and the core regions were analyzed. RESULTS:Rapid virological response was achieved in 0% (0/12) of NVR and in 75% (6/8) of relapse patients, with a significant difference between the two groups (p = 0.001). Similarly, cEVR was achieved in 8% (1/12) of NVR and in 88% (7/8) of relapse patients, with a significant difference between the two groups (p = 0.037). By multivariate logistic regression analysis, interleukin-28B major was a significant determiner of cEVR (odds ratio = 24.19, p = 0.037). CONCLUSION:DFPP + IFN-β/RBV then PEG-IFN/RBV therapy is indicated more for relapse than for NVR patients.

journal_name

Digestion

journal_title

Digestion

authors

Kim SR,Saito J,Imoto S,Komaki T,Nagata Y,Kim KI,Sasase N,Kimura N,Sasatani K,Konishi E,Hasegawa Y,Fujinami A,Ohta M,El-Shamy A,Tanaka Y,Sugano M,Sakashita M,Nakamura A,Tsuchida S,Makino T,Kawada T,Nakajima T,M

doi

10.1159/000333209

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

10-6

eissn

0012-2823

issn

1421-9867

pii

000333209

journal_volume

84 Suppl 1

pub_type

杂志文章
  • Vitamin D Status and Adiposity in Pediatric Malabsorption Syndromes.

    abstract:BACKGROUND:The combined effects of nutrient malabsorption and adiposity on vitamin D status are unclear in pediatric malabsorption syndromes. AIM:To determine the relationship between adiposity and serum 25-hydroxyvitamin D (25(OH)D) in malabsorption disorders. METHODS:Prepubertal children of ages 3-12 with either la...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000381895

    authors: Nwosu BU,Maranda L

    更新日期:2015-01-01 00:00:00

  • Galanin and vasoactive intestinal polypeptide: coexistence and corelease from the vascularly perfused pig ileum during distension and chemical stimulation of the mucosa.

    abstract::By immunohistochemistry and double staining technique, almost complete coexistence of galanin-like immunoreactivity (GAL-LI) and vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) was demonstrated in submucosal ganglionic cells and mucosal nerve fibers of the porcine ileum. The release of the two neurope...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200741

    authors: Harling H,Messell T,Poulsen SS,Rasmussen TN,Holst JJ

    更新日期:1991-01-01 00:00:00

  • Clinical isolation and characterization of Yersinia enterocolitica in China using real-time PCR and culture method.

    abstract:OBJECTIVE:To carry out a preliminary epidemiological investigation of Yersinia enterocolitica from a clinical perspective in China and to further validate the consistency of real-time polymerase chain reaction (RT-PCR) and culture method. METHODS:700 stool samples were randomly and continuously collected from in- and ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000108646

    authors: Zheng H,Wang J,Sun Y,Jiang B

    更新日期:2007-01-01 00:00:00

  • Treatment of postoperative Crohn's disease.

    abstract::At 1 year after a first resection, up to 80% of patients show an endoscopic recurrence, 10-20% have clinical relapse, and 5% have surgical recurrence. Smoking is one of the most important risk factors for postoperative recurrence. Preoperative disease activity and the severity of endoscopic lesions in the neoterminal ...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000083873

    authors: Froehlich F,Juillerat P,Felley C,Mottet C,Vader JP,Burnand B,Michetti P,Gonvers JJ

    更新日期:2005-01-01 00:00:00

  • Unnecessary Procedures and Surgery in Autoimmune Pancreatitis.

    abstract:BACKGROUND/AIMS:To identify the number and potential causes of unnecessary diagnostic procedures in a cohort of patients with autoimmune pancreatitis (AIP). METHODS:All AIP cases at our centre between April 2006 and April 2013 were collected and followed up. Diagnosis was established by the International Consensus Dia...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000437259

    authors: Manser CN,Gubler C,Müllhaupt B,Bauerfeind P

    更新日期:2015-01-01 00:00:00

  • OctreoTher: ongoing early clinical development of a somatostatin-receptor-targeted radionuclide antineoplastic therapy.

    abstract::OctreoTher ((90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide, a.k.a. (90)Y-SMT 487) consists of a somatostatin peptide analogue (Tyr(3)-octreotide), coupled with a complexing moiety (DOTA), and labeled with a tightly bound beta-emitter (yttrium-90). By targeting somatostatin receptor-positive tumors (as imaged by OctreaScan it m...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000051858

    authors: Smith MC,Liu J,Chen T,Schran H,Yeh CM,Jamar F,Valkema R,Bakker W,Kvols L,Krenning E,Pauwels S

    更新日期:2000-01-01 00:00:00

  • Role of circulating gastrin in colorectal adenomas and carcinomas.

    abstract:BACKGROUND/AIMS:A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS:In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations we...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007634

    authors: Lamberts R,Wartenberg T,Creutzfeldt W

    更新日期:1999-03-01 00:00:00

  • Pain in the Early Phase of Pediatric Pancreatitis (PINEAPPLE Trial): Pre-Study Protocol of a Multinational Prospective Clinical Trial.

    abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000441352

    authors: Zsoldos F,Párniczky A,Mosztbacher D,Tóth A,Lásztity N,Hegyi P,Hungarian Pancreatic Study Group and the International Association of Pancreatology.

    更新日期:2016-01-01 00:00:00

  • Questionnaire-based survey conducted in 2011 concerning endoscopic management of Barrett's esophagus in East Asian countries.

    abstract:BACKGROUND/AIMS:Endoscopic definitions and management of Barrett's esophagus vary widely among countries. To examine the current situation regarding diagnosis, epidemiology, management and treatment of Barrett's esophagus in East Asian countries using a questionnaire-based survey. METHODS:Representative members of the...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000339778

    authors: Ishimura N,Amano Y,Sollano JD,Zhu Q,Kachintorn U,Rani AA,Hahm KB,Takahashi S,Arakawa T,Joh T,Matsumoto T,Naito Y,Suzuki H,Ueno F,Fukudo S,Fujiwara Y,Kamiya T,Uchiyama K,Kinoshita Y,IGICS Study Group.

    更新日期:2012-01-01 00:00:00

  • Role of alimentation in irritable bowel syndrome.

    abstract:BACKGROUND:Different food items are made responsible for irritable bowel syndrome (IBS) symptoms, but the physiopathology of IBS remains unclear. AIMS:During a meeting in Nice, France, experts of the European Working Team of the IBiS Club discussed selected data regarding the relationships between alimentation, food i...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000072061

    authors: Dapoigny M,Stockbrügger RW,Azpiroz F,Collins S,Coremans G,Müller-Lissner S,Oberndorff A,Pace F,Smout A,Vatn M,Whorwell P

    更新日期:2003-01-01 00:00:00

  • Long-term outcome after double-balloon endoscopy in patients with obscure gastrointestinal bleeding.

    abstract:BACKGROUND AND AIMS:There are limited data concerning the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) after double-balloon endoscopy (DBE). The aim of the present study was to evaluate the long-term outcome of patients with OGIB after DBE. PATIENTS AND METHODS:Eighty-seven consecutive pa...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000313360

    authors: Fujita M,Manabe N,Honda K,Tarumi K,Murao T,Katada S,Kimura Y,Matsumoto H,Kamada T,Shiotani A,Hata J,Haruma K

    更新日期:2010-01-01 00:00:00

  • Increased iron absorption in uroporphyrin-treated rats.

    abstract::Rats were given 59Fe (28 micrograms) together with doses of 0, 2 and 200 micrograms of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 micrograms of uroporphyrin twice daily for 3 days was ass...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200714

    authors: Weaver GA,Franck CA,Harris MD,Peters T Jr

    更新日期:1991-01-01 00:00:00

  • Omeprazole in the treatment of Zollinger-Ellison syndrome and histamine H2-antagonist refractory ulcers.

    abstract::Omeprazole is a very potent and long-acting inhibitor of gastric acid secretion. These characteristics make the drug very suitable for the management of gastric acid hypersecretion and symptom relief in patients with the Zollinger-Ellison syndrome, and in the treatment of patients with ulcers resistant to histamine H2...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200102

    authors: Meijer JL,Jansen JB,Lamers CB

    更新日期:1989-01-01 00:00:00

  • What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.

    abstract:BACKGROUND/AIMS:Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000229773

    authors: Shiga H,Takagi S,Inoue R,Kinouchi Y,Ohkubo T,Takahashi S,Negoro K,Yokoyama H,Kato S,Fukushima K,Hiwatashi N,Shimosegawa T

    更新日期:2010-01-01 00:00:00

  • Prevalence of minimal change lesions in patients with non-erosive reflux disease: a case-control study.

    abstract:BACKGROUND/AIMS:Some minimal changes (MCs) are believed to have a certain relationship with gastroesophageal reflux (GERD). Nonetheless, the individual meaning of MC is still unclear. Our aim was to compare the overall and individual prevalence of MC between patients with non-erosive reflux disease (NERD) and healthy c...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000337198

    authors: Kim JB,Shin SR,Shin WG,Choi MH,Jang HJ,Kim KO,Park CH,Baek IH,Baik GH,Kim KH,Park SH,Kae SH,Lee MS,Kim HY

    更新日期:2012-01-01 00:00:00

  • Chemiluminescence by polymorphonuclear leucocyte subpopulations in chronic inflammatory bowel disease. Influence of the cell separation procedure.

    abstract::Chemiluminescence (CL) is a simple quantitative assay of polymorphonuclear leucocyte (PMNL) oxidative metabolism. PMNL CL was found to be significantly higher in patients with chronic inflammatory bowel disease than in normal controls (167 +/- 60 vs. 139 +/- 50 mV/10(5) cells, p less than 0.05). There were no signific...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200238

    authors: Kelleher D,Feighery C,Weir DG

    更新日期:1990-01-01 00:00:00

  • Plasmapheresis in Crohn's disease.

    abstract::6 patients with Crohn's disease for 1-14 years have been treated with plasmapheresis for periods of up to 6 months. The symptoms of the one newly diagnosed patient were controlled by plasmapheresis alone, and 5 steroid-dependent patients were able to reduce their steroid requirements. During the study period, 13 clini...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198344

    authors: Holdstock GE,Fisher JA,Hamblin TJ,Loehry C

    更新日期:1979-01-01 00:00:00

  • Lecithin: cholesterol acyltransferase activity in patients with chronic liver diseases and positive LP-X tests.

    abstract::Lecithin: cholesterol acyltransferase activity has been measured in serum from patients with various liver disorders and positive LP-X tests and from healthy subjects. Statistical analysis indicated that lecithin: cholesterol acyltransferase activity provided no help in the discrimination between the persons of both g...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198149

    authors: Jung K,Schimmelpfennig W,Wack R,Neumann R

    更新日期:1978-01-01 00:00:00

  • Esophageal Cancer: New Insights into a Heterogenous Disease.

    abstract:BACKGROUND:Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000464130

    authors: Krug S,Michl P

    更新日期:2017-01-01 00:00:00

  • Hesperidin Improves Colonic Motility in Loeramide-Induced Constipation Rat Model via 5-Hydroxytryptamine 4R/cAMP Signaling Pathway.

    abstract::Fructus has motivation effect on gastrointestinal tract. Hesperidin is extracts of Fructus, and we attempted to prove its effects on improving the gastrointestinal transmission function and determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. Constipation phenotypes were mea...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000501959

    authors: Wu M,Li Y,Gu Y

    更新日期:2020-01-01 00:00:00

  • Carcinomas of the colon in Buffalo strain rats given intraperitoneal injections of methylazoxymethanol acetate.

    abstract::Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197946

    authors: Reuber MD

    更新日期:1976-01-01 00:00:00

  • Somatostatin for the prevention of complications following pancreatoduodenectomy.

    abstract::Pancreatoduodenectomy (PD) may be followed by serious complications chiefly associated with exocrine pancreatic secretion. Somatostatin and its analogues are able to inhibit pancreatic secretion and thus have been advocated for the prevention of complications following pancreatic surgery. In four published multicentri...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000051490

    authors: Gouillat C

    更新日期:1999-01-01 00:00:00

  • Acute pancreatitis in the Guangdong Province, China.

    abstract:BACKGROUND/AIMS:Many studies have recently been published on acute pancreatitis; however, few large-sample studies have been focused on the risk factors for deaths in severe acute pancreatitis. To address this issue, the present study was intended to assess etiology, severity, and mortality of acute pancreatitis in the...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000102959

    authors: Bai Y,Jia L,Wang B,Yang B,Wang L,Shi X,Zhang W,Liu Y,Zou D,Li Z

    更新日期:2007-01-01 00:00:00

  • Fasting and postprandial serum bile acid concentrations in normal persons using an improved GLC method.

    abstract::An improved GLC method was employed to study individual serum bile acids in 14 control subjects after a 12-hour fast followed by a standard fatty meal. Peripheral venous blood samples were obtained at 15-min intervals for up to 2 h in 7 subjects, and 4 h in 2 subjects. The fasting total bile acids, and cholic:chenodeo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198094

    authors: Pennington CR,Ross PE,Bouchier IA

    更新日期:1978-01-01 00:00:00

  • A Randomized, Double-Blind, Pilot Study of the Effect of Famotidine on Acotiamide Treatment for Functional Dyspepsia.

    abstract:BACKGROUND/AIMS:Acotiamide, a prokinetic drug, is used to treat functional dyspepsia (FD), especially postprandial distress syndrome (PDS). However, a treatment for FD patients with PDS and/or epigastric pain syndrome (EPS) has not been established. We investigated the efficacy of famotidine in combination with acotiam...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000477345

    authors: Hojo M,Nagahara A,Asaoka D,Takeda T,Izumi K,Matsumoto K,Ueyama H,Shimada Y,Matsumoto K,Nojiri S,Watanabe S

    更新日期:2017-01-01 00:00:00

  • Polyamine uptake across the basolateral membrane of the enterocyte is mediated by a high-affinity carrier: a study using isolated basolateral membrane vesicles.

    abstract:BACKGROUND/AIMS:Polyamine uptake from the circulation plays an important role in the maintenance of the intracellular polyamine content during extensive proliferation in intestinal mucosal cells. METHODS:Isolated basolateral membrane vesicles of the rabbit enterocyte were used to characterize polyamine transport acros...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007468

    authors: Milovic V,Caspary WF,Stein J

    更新日期:1998-01-01 00:00:00

  • Comparison of caerulein and cholecystokinin effects upon enzyme concentrations in duodenal aspirates.

    abstract::The effect of maximal doses of cholecystokinin and caerulein on lipase and chymotropsin concentrations were compared in large groups of patients with almost equal capacities of bicarbonate secretion. The responsiveness of the pancreas is, as a whole, higher with caerulein than with cholecystokinin, this feature being ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197987

    authors: Minaire Y,Descos L

    更新日期:1977-01-01 00:00:00

  • Total denervation of the pancreas does not alter the pancreatic polypeptide response to food intake.

    abstract::The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199492

    authors: Köhler H,Becker HD

    更新日期:1987-01-01 00:00:00

  • Special functional features of T-lymphocyte subpopulations in the effector compartment of the intestinal mucosa and their relation to mucosal transformation.

    abstract::Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal gr...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000200398

    authors: Zeitz M,Schieferdecker HL,James SP,Riecken EO

    更新日期:1990-01-01 00:00:00

  • A rapid method of relating protein to flow in human pancreatic secretions.

    abstract::A method of obtaining linear plots of protein-flow data from human pancreatic ductal secretions is described. The protein concentration in pancreatic secretions, when related to flow rates in two individuals, gave similar regression lines, with the correlation coefficients or r = -0.97 and -0.98, respectively, and slo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197922

    authors: Allan BJ,White TT

    更新日期:1976-01-01 00:00:00