Prevalence of minimal change lesions in patients with non-erosive reflux disease: a case-control study.

Abstract:

BACKGROUND/AIMS:Some minimal changes (MCs) are believed to have a certain relationship with gastroesophageal reflux (GERD). Nonetheless, the individual meaning of MC is still unclear. Our aim was to compare the overall and individual prevalence of MC between patients with non-erosive reflux disease (NERD) and healthy controls (HC). METHODS:Twelve endoscopic findings in the esophagogastric junction were prospectively compared between NERD (n = 64) and control (n = 104). RESULTS:Overall frequency of MC (≥ 1 out of 12 criteria) was higher in the NERD group (71.9%) than in the HC group (45.2%). In individual analysis, white mucosal turbidity, irregular Z-line, horizontal erosions, and mucosal protrusion of cardia were significantly more common in the NERD group compared to controls. Among them, only white mucosal turbidity was independently associated with the NERD group (OR 3.97, 95% CI 1.72-9.13). Individuals with male gender, reflux symptoms, higher height, current smoking, ethanol intake and hiatal hernia were more likely to have white mucosal turbidity compared to the group without white turbidity. CONCLUSIONS:MC could be a useful marker to support clinical diagnosis of GERD. White mucosal turbidity in particular might be a GERD-specific sign related to acid-induced mucosal damage.

journal_name

Digestion

journal_title

Digestion

authors

Kim JB,Shin SR,Shin WG,Choi MH,Jang HJ,Kim KO,Park CH,Baek IH,Baik GH,Kim KH,Park SH,Kae SH,Lee MS,Kim HY

doi

10.1159/000337198

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

288-94

issue

4

eissn

0012-2823

issn

1421-9867

pii

000337198

journal_volume

85

pub_type

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