Failure of a prolyl 4-hydroxylase inhibitor to alter extracellular matrix deposition during experimental pancreatitis.

abstract：BACKGROUND/AIM:The aim of this study was to examine the relationship between narrow-band imaging (NBI) magnifying observation using the surface pattern as the main evaluation criterion and pit pattern diagnosis on the basis of magnifying observation using a dye in relation to the characteristics of colorectal tumors ac...

journal_title：Digestion

authors： Hayashi N,Tanaka S,Kanao H,Oka S,Yoshida S,Chayama K

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The importance of microbiota infiltrating the gut mucus layer has been reported in the pathogenesis of various gastrointestinal and systemic diseases. However, little is known about the mucosa-associated microbiota (MAM) in healthy subjects. The present study aimed to clarify the characteristics of the gastr...

journal_title：Digestion

authors： Kashiwagi S,Naito Y,Inoue R,Takagi T,Nakano T,Inada Y,Fukui A,Katada K,Mizushima K,Kamada K,Uchiyama K,Handa O,Ishikawa T,Itoh Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The aim of this study was to see whether administration of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, could prevent the development of gastric cancer via inhibition of apurinic/apyrimidinic endonuclease-1 (APE-1) expression induced by Helicobacter pylori infection. METHODS:70 Mongol...

journal_title：Digestion

authors： Futagami S,Kawagoe T,Horie A,Shindo T,Hamamoto T,Suzuki K,Kusunoki M,Miyake K,Gudis K,Tsukui T,Crowe SE,Sakamoto C

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:An abnormal immune response may play a pathogenetic role in chronic pancreatitis. However, to date characterization of the systemic immunological changes in patients with chronic pancreatitis has not been undertaken. METHODS:Lymphocyte phenotypes and proliferation ((3)H-thymidine) after stimulation with mit...

journal_title：Digestion

authors： Ockenga J,Jacobs R,Kemper A,Benschop RJ,Schmidt RE,Manns MP

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...

journal_title：Digestion

authors： Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

更新日期：2007-01-01 00:00:00

abstract：:The ratio of 6beta-hydroxycortisol to 17-hydroxycorticosteroids in the urine of 73 patients with liver disease, and 53 controls has been measured. The mean ratio was significantly greater in the liver disease group (p less than 0.001), this elevation being most marked among patients with liver metastases and patients ...

journal_title：Digestion

authors： Eade OE,Maddison A,Leonard PJ,Wright R

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND/AIMS:There are many reports of non-alcoholic fatty liver disease (NAFLD) patients with increased carotid intima-media thickness (IMT). However, there is little information about carotid IMT in alcoholic fatty liver disease (AFLD) patients. We aimed to compare the carotid IMT of NAFLD patients and AFLD patien...

journal_title：Digestion

authors： Kim JH,Kim SY,Jung ES,Jung SW,Koo JS,Kim JH,Yeon JE,Kwon SY,Lee SW,Byun KS,Lee CH

更新日期：2011-01-01 00:00:00

abstract：:The secretion of pancreatic polypeptide (PP) seems to be controlled by vagal cholinergic mechanisms, since both vagotomy and atropine significantly inhibit the PP response to food intake, sham feeding or insulin hypoglycaemia. In the present study, we examined the PP response to a meal after orthotopic autotransplanta...

journal_title：Digestion

authors： Köhler H,Becker HD

更新日期：1987-01-01 00:00:00

abstract：AIMS:To evaluate the prevalence of proximal reflux and esophago-bronchial reflex (EBR) in patients with asthma, and to compare the symptom spectrum, esophageal acid sensitivity, pH monitoring, and the endoscopic and manometric parameters of EBR-positive and -negative patients with asthma. PATIENTS AND METHODS:Forty-th...

journal_title：Digestion

authors： Rosztóczy A,Makk L,Izbéki F,Róka R,Somfay A,Wittmann T

更新日期：2008-01-01 00:00:00

abstract：:Human gastric mucosal adenylate cyclase has been shown to be sensitive to histamine and catecholamines. Stimulation of enzyme activity by histamine and catecholamines were selectively blocked by cimetidine and propranolol, respectively. Combination of both hormones at maximally effective concentrations were additive, ...

journal_title：Digestion

authors： Simon B,Kather H

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to evaluate the frequency of anatomic variations of the hepatic duct bifurcation using magnetic resonance cholangiopancreatography (MRCP). METHODS:A total of 1,160 consecutive patients, referred to our department for MRCP due to suspected pancreatobiliary disease or before liver tra...

journal_title：Digestion

authors： Uysal F,Obuz F,Uçar A,Seçil M,Igci E,Dicle O

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The present study aimed to evaluate the micronucleus (MN), nucleoplasmic bridges (NPBs) and nuclear buds (NBUDs) in the mitogen-stimulated lymphocytes of patients with ulcerative colitis (UC). In addition, we assessed MN frequency in exfoliated colonic epithelial cells obtained from both the diseased and heal...

journal_title：Digestion

authors： Karaman A,Hamurcu Z,Donmez H,Bitken N,Karaman H,Baskol M,Gursoy S,Guven K,Ozbakir O,Yucesoy M

更新日期：2012-01-01 00:00:00

abstract：:The role of altered gastric motor functions for the development of obesity is still unclear. In this study, we investigated whether severe obesity is related to gastric dysfunctions or to abnormal perception in response to distension. 31 obese patients and 20 healthy volunteers were studied using an electronic barosta...

journal_title：Digestion

authors： Klatt S,Pieramico O,Güthner C,Ditschuneit HH,Glasbrenner B,Beckh K,Adler G

更新日期：1997-01-01 00:00:00

abstract：:To assess the sensitivity, specificity and clinical value of prealbumin as liver test, prealbumin plasma levels were measured in 100 patients with liver disease and in 65 patients without clinical evidence of liver impairment. The sensitivity of prealbuminemia was higher than that of albumin, pseudocholinesterase, apo...

journal_title：Digestion

authors： Rondana M,Milani L,Merkel C,Caregaro L,Gatta A

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Determining the depth of invasion is important when considering therapeutic strategies for early gastric cancer (EGC). We determined the effects of learning the non-extension sign, that is, an index of T1b2 in EGC, on identifying its depth of invasion. METHODS:Endoscopic images of 40 EGC cases (20 showing p...

journal_title：Digestion

authors： Takeda T,So S,Sakurai T,Nakamura S,Yoshikawa I,Yada S,Itaba S,Yamagata H,Akiho H,Takatsu N,Wada Y,Ohtsu K,Nagahama T,Yao K

更新日期：2020-01-01 00:00:00

abstract：:Mucosal intestinal cells migrate and differentiate simultaneously as they move out of the crypts to their functional site along the villus. Interactions between the enterocyte basal membrane domain and the extracellular intestinal basement membrane (IBM) have been suggested to be essential to both cell migration and d...

journal_title：Digestion

authors： Wilson JR,Weiser MM

更新日期：1990-01-01 00:00:00

abstract：:Recently our studies have demonstrated that the central nervous system regulates in part mucosal cell growth and apoptosis in the rat small intestine. Ornithine decarboxylase (ODC) activity is a key enzyme for polyamine synthesis which plays an important role for the intestinal mucosal growth. We have demonstrated tha...

journal_title：Digestion

authors： Fujimoto K,Iwakiri R,Utsumi H,Kojima M,Ishibashi S,Wu B,Sakata H,Noda T

更新日期：2001-01-01 00:00:00

abstract：:One to four months after implantation of a gastric fistula, a circadian rhythm in gastric acidity could be demonstrated by use of the intragastric 24-hour pH-metry in dogs with the gastric fistula protruding on the left side of the upper abdomen. This circadian rhythm was found to be fully developed within 3 years, an...

journal_title：Digestion

authors： Postius S,Bräuer U

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND/AIMS:Currently, a split-dose of polyethylene glycol (PEG) is the mainstay of bowel preparation due to its tolerability, bowel-cleansing action, and safety. However, bowel preparation with PEG is suboptimal because residual fluid reduces the polyp detection rate and requires a more thorough colon inspection. ...

journal_title：Digestion

authors： Kim HJ,Kim TO,Shin BC,Woo JG,Seo EH,Joo HR,Heo NY,Park J,Park SH,Yang SY,Moon YS,Shin JY,Lee NY

更新日期：2012-01-01 00:00:00

abstract：:We have previously shown a specific significant overexpression in the exocrine pancreatic tissue of two members of the regenerating gene multifamily: reg I and reg II in the non-obese diabetic (NOD) mouse during active diabetogenesis. To strengthen the hypothesis that the overexpression of these genes may represent a ...

journal_title：Digestion

authors： Baeza N,Sanchez D,Christa L,Guy-Crotte O,Vialettes B,Figarella C

更新日期：2001-01-01 00:00:00

abstract：:In order to evaluate the mechanism behind the augmented postprandial gastric inhibitory polypeptide (GIP) release seen in patients with achlorhydria and hypergastrinemia, 8 healthy subjects were given a liquid test meal on three different days. On 1 day the meal was preceded by ranitidine (H2 receptor antagonist) to b...

journal_title：Digestion

authors： Jorde R,Schulz TB,Burhol PG,Waldum HL

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...

journal_title：Digestion

authors： Fanti L,Mezzi G,Cavallero A,Gesu G,Bonato C,Masci E

更新日期：1999-09-01 00:00:00

abstract：:This study evaluated the effect of a cellulose meal and a cellulose-oleic acid meal on gastroduodenal motility and gastric emptying. The cellulose meal produced a high antral motility index (100 +/- 34 V/10 min) and a high proportion (80.2%) of propulsive duodenal contractions. The oleic acid meal was associated with ...

journal_title：Digestion

authors： Schemann M,Ehrlein HJ

更新日期：1982-01-01 00:00:00

abstract：:5 healthy volunteers were submitted to i.v. infusion for 45 min of graded doses of commercial GIH secretin (0.01, 0.025, 0.05, 0.5, 1 and 2 CU/kg h-1). Parathormone serum levels were measured before and during the infusion. All the dosages of exogenous secretin were followed by a significant increase in serum PTH leve...

journal_title：Digestion

authors： Piubello W,Cominacini L,Vantini I,Brocco G,Benini L,Cavallini G,Lo Cascio V,Scuro LA

更新日期：1981-01-01 00:00:00

abstract：:Recent studies indicate that intestinal lamina propria T cells are highly specialized lymphocytes, which differ from T cells in other compartments of the immune system in several respects. In the present study phenotypic and functional characteristics of lamina propria T cells and their possible relation to mucosal gr...

journal_title：Digestion

authors： Zeitz M,Schieferdecker HL,James SP,Riecken EO

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND AND AIM:Sonic hedgehog (Shh) is a morphogen involved in the homeostasis of the gastric fundic glands. Alterations of gastric mucosal Shh expression after eradication of Helicobacter pylori were examined. METHOD:Mongolian gerbils were inoculated with H. pylori at the age of 5 weeks. H. pylori eradication was...

journal_title：Digestion

authors： Nishizawa T,Suzuki H,Nakagawa I,Minegishi Y,Masaoka T,Iwasaki E,Hibi T

更新日期：2009-01-01 00:00:00

abstract：UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethano...

journal_title：Digestion

authors： Konturek SJ,Robert A

更新日期：1982-01-01 00:00:00

abstract：:The aim of this study was to evaluate the serum behavior of human pancreas-specific protein/procarboxypeptidase B (hPASP/PCPB) in the early phases of acute pancreatitis, and to calculate its sensitivity and specificity in comparison with those of serum amylase and lipase in the diagnosis of this illness. Twenty-six ac...

journal_title：Digestion

authors： Pezzilli R,Billi P,Platè L,Bongiovanni F,Morselli Labate AM,Miglioli M

更新日期：1994-01-01 00:00:00

abstract：:Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...

journal_title：Digestion

authors： Rune S

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The exact etiology of irritable bowel syndrome (IBS) remains unclear. Curative treatment is not available and current treatment modalities are mainly directed against the predominant symptoms. There are a few studies reporting the beneficial effects of transcutaneous electrical stimulation in patients with c...

journal_title：Digestion

authors： Coban Ş,Akbal E,Köklü S,Köklü G,Ulaşlı MA,Erkeç S,Aktaş B,Yüksel O,Koçak E,Erdem HR

更新日期：2012-01-01 00:00:00