Abstract:
UNLABELLED:This study examined the role of the gastric mucosal blood flow (MBF) in the gastric cytoprotection produced by prostacyclin (PGI2) and prostaglandin E2 (PGE2) in dogs. An acidified solution of saline was applied topically on the canine gastric mucosa with and without ethanol at various concentrations. Ethanol applied to the mucosa of a stomach flap preparation, in concentrations ranging from 5 to 80%, gradually decreased the transmucosal potential difference (PD) from -58 to -5 mV and increased net ionic fluxes. MBF gradually increased at lower concentrations of ethanol, reaching the peak of about 50% above basal at 20% ethanol and then declining at 40 and 80% ethanol. PGI2 (10 micrograms/kg/h) prevented the changes in PD and ion fluxes produced by lower but not higher concentrations of ethanol and this was accompanied by a marked increase in the MBF above the level produced by ethanol alone. The instillation of acidified 15% ethanol into Heidenhain pouch (HP) reduced the PD from -57 to -40 mV and elicited large net H+ and Na+ fluxes. MBF was increased by 30%. PGI2 (10 micrograms/kg/h) completely prevented ethanol-induced changes in PD, reduced ionic fluxes, and raised the MBF twofold. On the contrary PGE2 (80 micrograms/kg/h) did not affect ethanol-induced alterations in PD, ion fluxes, and MBF. CONCLUSIONS:PGI2, but not PGE2, effectively protects the canine gastric mucosa against the damage produced by ethanol. This cytoprotection may be due to increased mucosal circulation, which by an unknown mechanism interferes with the mucosal damage caused by ethanol.
journal_name
Digestionjournal_title
Digestionauthors
Konturek SJ,Robert Adoi
10.1159/000198824subject
Has Abstractpub_date
1982-01-01 00:00:00pages
155-63issue
3eissn
0012-2823issn
1421-9867journal_volume
25pub_type
杂志文章相关文献
DIGESTION文献大全abstract::Combining the narrow-band imaging (NBI) system and magnifying endoscopy allows simple and clear visualization of microscopic structures of the superficial mucosa and its capillary patterns, which may be useful for precise endoscopic diagnosis in the gastrointestinal tract, being more closely to histopathological diagn...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000321799
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Multiple colorectal polyps with a diameter in the range of 10-19 mm are unable to be retrieved through a 3-mm endoscopic channel by the aspiration method. This study aims to assess the usefulness of Catcher Tag retrieval, which not only allows the accurate identification of the resected location but als...
journal_title:Digestion
pub_type: 杂志文章,随机对照试验
doi:10.1159/000484043
更新日期:2017-11-01 00:00:00
abstract:AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000051872
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Bile duct stones (BDS) are usually removed via endoscopic retrograde cholangiopancreatography (ERCP) or, if ERCP remains unsuccessful, percutaneous transhepatic cholangiodrainage (PTCD). However, PTCD provides limited access to large BDSs. We analyzed a modified approach of PTCD for percutaneous therapy of B...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000485179
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIM:Over the past 15 years, there were considerable changes in factors associated with the development and treatment of upper gastrointestinal symptoms, of which the introduction of proton pump inhibitors and Helicobacter pylori eradication in guidelines for treatment of patients with dyspepsia are the most ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000110684
更新日期:2007-01-01 00:00:00
abstract::The elimination kinetics of antipyrine have been established under basal environmental conditions in 6 healthy volunteers. Concentrations of antipyrine in serum were measured by a relatively fast high-pressure liquid chromatography method using a radial-compression chromatographic system. Pretreatment of the subjects ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198918
更新日期:1983-01-01 00:00:00
abstract::Indicators of net water movement are used in a variety of intestinal transport studies. Such indicators should be virtually unabsorbed under study conditions. The effects of stimuli that alter intestinal mass on indicator recovery have not been examined. We used the male albino rat to study the effects of food restric...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199576
更新日期:1987-01-01 00:00:00
abstract::Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) f...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000198444
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Overt hepatic encephalopathy (HE) following insertion of a transjugular intrahepatic portosystemic shunt (TIPS) is a problem in some patients. In contrast to overt HE, minimal HE (MHE) following TIPS is studied to a limited degree only. We therefore evaluated the incidence of MHE in patients following TIPS i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000288522
更新日期:2011-01-01 00:00:00
abstract::The clinical value of the tumor marker human chorionic gonadotropin-beta (hCG-beta) in ascitic fluid for the differentiation of malignancy-related and non-malignant ascites was evaluated. Ascitic fluid protein, cholesterol and cytological examination were determined for comparison. Thirty-six patients with malignancy-...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201324
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Fecal lactoferrin has been introduced as a useful tool for the diagnosis and monitoring of inflammatory bowel disease (IBD). The aim of this study was to assess if fecal lactoferrin can be employed to predict or estimate the effect of granulocyte and monocyte adsorptive apheresis (GMA) in ulcerative colitis ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000375301
更新日期:2015-01-01 00:00:00
abstract::Autonomic hyperactivity with increased cardiac output and other manifestations occurs in patients with both cirrhosis and noncirrhotic portal hypertension. The role of the disordered hepatic autonomic innervation in the mediation of these abnormalities is unknown. We have studied the hepatic nerve network and associat...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201156
更新日期:1994-01-01 00:00:00
abstract::We describe a patient with relapses of Clostridium difficile cytotoxin-positive pseudomembranous colitis (PMC) after treatment with vancomycin, a course of metronidazole and a trial of bacitracin. She remains free of disease after a prolonged course of cholestyramine. We suggest there may be a role for anion-exchange ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199299
更新日期:1986-01-01 00:00:00
abstract::Several previous studies have shown that the plasma concentration of gamma-amino-butyric acid (GABA) is markedly increased in patients with hepatic encephalopathy, and it has been suggested that decreased metabolism of peripheral GABA might contribute to the cerebral dysfunctions observed. In the present study, plasma...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200724
更新日期:1991-01-01 00:00:00
abstract::Germ-free and conventional rats were fed a semi-synthetic diet including 10% wheat bran for 1 month. They were compared to similar rats fed the same diet without bran. Transit of polyethylene glycol (PEG) 4000 was studied in giving the marker either in saline or in the diet. The presence of a bacterial flora was found...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199006
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000112646
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Leptin is a pleiotropic hormone that is involved in the regulation of food intake and body weight. Recent findings demonstrated that leptin receptors are present in the pancreas but the involvement of leptin in pancreatitis remains unknown. The aim of the present study was: (1) to assess plasma leptin levels...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000064935
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND AND AIMS:There are limited data concerning the clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) after double-balloon endoscopy (DBE). The aim of the present study was to evaluate the long-term outcome of patients with OGIB after DBE. PATIENTS AND METHODS:Eighty-seven consecutive pa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000313360
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Human colorectal neuroendocrine cell carcinoma (NEC) is a rare disease with a poor prognosis. The biological behavior of NEC remains poorly understood. MATERIALS AND METHODS:We established two new NEC cell lines from a patient with rectal neuroendocrine carcinoma, NECS-P and NECS-L from the primary tumor an...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000007825
更新日期:2000-01-01 00:00:00
abstract::Neutrophil motility in normal subjects and Crohn's disease patients was assessed using both double and single filter assay systems with n-formylmethionylleucylphenylalanine (FMLP) as the attractant, and in a single filter assay with Candida albicans in 10% serum as the attractant. Assays were performed in triplicate a...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200680
更新日期:1991-01-01 00:00:00
abstract::Familial colorectal cancer (CRC) is heterogeneous. Screening recommendations do exist for individuals with a mild to moderate family history of CRC, with or without early age at onset. However, most attention has properly focused on the identification of individuals in whom a defined susceptibility gene mutation can b...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000108395
更新日期:2007-01-01 00:00:00
abstract::Buffalo strain male and female rats were given methylazoxymethanol acetate (20% solution) intraperitoneally 20 mg/kg body weight weekly for 9 weeks, and killed 27 weeks later. Carcinomas of the large intestine, predominantly in the descending colon, developed in some of the rats. The incidence was higher in male than ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000197946
更新日期:1976-01-01 00:00:00
abstract::Rectal biopsies were maintained in organ culture over a 24-hour culture period, with good preservation of histological architecture. A filtrate containing Clostridium difficile toxin significantly inhibited the rise in epithelial alkaline phosphatase activity normally seen during culture. This effect was abolished by ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199212
更新日期:1985-01-01 00:00:00
abstract::Eighteen cases of severe hyperplasia of fundic argyrophil cells observed during routine histologic examination of endoscopic gastric biopsy specimens from unselected patients with upper gastro-intestinal symptomatology were investigated. All patients, except one, were female with a mean age of 57 years. Atrophic gastr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000199389
更新日期:1986-01-01 00:00:00
abstract::The activities of pancreatic enzymes decrease during their passage from the duodenum to the terminal ileum, but degradation rates of individual enzymes are different. Whereas lipase activity is lost most rapidly, proteases and amylase are more stable. The mechanism by which lipase activity is destroyed is proteolysis,...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201097
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND/AIMS:Although considerable information exists regarding gastroesophageal reflux disease with erosions, much less is known of non-erosive reflux disease (NERD), the dominant form of reflux disease in the developed world. METHODS:An expert international group using the modified Delphi technique examined the q...
journal_title:Digestion
pub_type: 共识发展会议,杂志文章
doi:10.1159/000219365
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Different food items are made responsible for irritable bowel syndrome (IBS) symptoms, but the physiopathology of IBS remains unclear. AIMS:During a meeting in Nice, France, experts of the European Working Team of the IBiS Club discussed selected data regarding the relationships between alimentation, food i...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000072061
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIMS:Endoscopic definitions and management of Barrett's esophagus vary widely among countries. To examine the current situation regarding diagnosis, epidemiology, management and treatment of Barrett's esophagus in East Asian countries using a questionnaire-based survey. METHODS:Representative members of the...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000339778
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Since resistance of Helicobacter pylori is developing very fast all over the world, new treatment regimens for eradication are urgently needed. AIM:To compare eradication success rate of H. pylori treatment regimens with and without doxycycline. METHODS:English medical literature searches were conducted fo...
journal_title:Digestion
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000443683
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:There are unexpectedly large differences between the incidences of acute pancreatitis (AP) as indicated by different hospitals. Retrospective studies suggest that the reason behind this is the large differences that exist between the local managements of abdominal pain at emergency units. Unfortunately, no e...
journal_title:Digestion
pub_type: 杂志文章,多中心研究
doi:10.1159/000441352
更新日期:2016-01-01 00:00:00