Effect of wheat bran upon gastro-intestinal transit in germ-free and conventional rats.

Abstract:

:Germ-free and conventional rats were fed a semi-synthetic diet including 10% wheat bran for 1 month. They were compared to similar rats fed the same diet without bran. Transit of polyethylene glycol (PEG) 4000 was studied in giving the marker either in saline or in the diet. The presence of a bacterial flora was found to accelerate small intestine transit and total transit. The ingestion of solid food slowed gastric emptying but had little effect on small intestine transit. Wheat bran slowed gastric emptying of PEG in most of the experimental groups. It had no significant effect on small intestine transit except in germ-free rats having received the marker in solid food. It accelerated total transit in germ-free and conventional rats. The results suggest that bran mainly exerts its action in the hindgut. The role of microflora in this action of bran is discussed.

journal_name

Digestion

journal_title

Digestion

authors

Riottot M,Sacquet E,Leprince C

doi

10.1159/000199006

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

37-41

issue

1

eissn

0012-2823

issn

1421-9867

journal_volume

29

pub_type

杂志文章
  • Cholecystokinin in the inhibition of gastric secretion and gastric emptying in humans.

    abstract::Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled. In this study performed on 16 young male subjects, gastric acid secretion and emptying rate were determined after intragastric administration of 8% pep...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200218

    authors: Konturek SJ,Kwiecien N,Obtulowicz W,Kopp B,Oleksy J,Rovati L

    更新日期:1990-01-01 00:00:00

  • Therapeutic efficacy of leukocytapheresis in a pregnant woman with severe active ulcerative colitis.

    abstract::Leukocytapheresis has recently been used to induce remission in patients with ulcerative colitis (UC) who fail to respond to corticosteroids. We could not find a report in the literature on leukocytapheresis for UC with gestational exacerbation. We have recently encountered this unique condition and report the details...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000095478

    authors: Okada H,Makidono C,Takenaka R,Hiraoka S,Fujiwara A,Kato J,Kawahara Y,Kawamoto H,Mizuno M,Shiratori Y

    更新日期:2006-01-01 00:00:00

  • Potential indications for octreotide in gastroenterology: summary of workshop.

    abstract::The potential therapeutic applications of somatostatin and octreotide in gastroenterology involve gut neuro-endocrine tumours, bleeding varices, bleeding peptic ulcers, gastro-intestinal fistulae, pancreatic fistulae, dumping syndrome, pancreatic pseudocysts, short bowel syndrome, acute pancreatitis, AIDS-related diar...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201079

    authors: Burroughs AK,Malagelada R

    更新日期:1993-01-01 00:00:00

  • Metal absorption and the intestinal mucus layer.

    abstract::The luminal mucus layer of the rat's small intestine was separated from the mucosa by filling the lumen with agar jelly. When the rats were fasted overnight and given 59Fe or 65Zn by stomach tube the mucus isolated by this technique contained more isotope and more sialic acid than fed controls, and more of the isotope...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199480

    authors: Quarterman J

    更新日期:1987-01-01 00:00:00

  • A Multicenter Prospective Survey on Early-Onset Inflammatory Bowel Disease in Japan.

    abstract:INTRODUCTION:The incidence of early-onset inflammatory bowel disease is increasing in Japan. OBJECTIVE:This study aimed to analyze the treatment and progress of early-onset inflammatory bowel disease. METHODS:This prospective survey evaluated the data of 43 patients aged <8 years who were diagnosed with inflammatory ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000507570

    authors: Kudo T,Fujii T,Maisawa SI,Sasaki M,Uchida K,Ida S,Kagimoto S,Yoden A,Shimizu T

    更新日期:2020-05-18 00:00:00

  • Esophageal Cancer: New Insights into a Heterogenous Disease.

    abstract:BACKGROUND:Esophageal cancer represents a heterogeneous malignancy mostly diagnosed in advanced stages. Worldwide, squamous cell carcinomas (SCCs) continue to be the most prevalent subtype; however, in the Western countries, the incidence of adenocarcinomas is increasing and will exceed that of SCC in the near future. ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000464130

    authors: Krug S,Michl P

    更新日期:2017-01-01 00:00:00

  • Expression of transforming growth factor-beta 1 in chronic pancreatitis.

    abstract::Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine which modifies tissue stromal matrix synthesis, cell proliferation and immune function. In the present study, we have used a mouse monoclonal antibody to the latent (intracytoplasmic) form of TGF-beta 1 to compare its expression in 144 cases ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201249

    authors: Slater SD,Williamson RC,Foster CS

    更新日期:1995-01-01 00:00:00

  • Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related chronic gastritis.

    abstract::Combining the narrow-band imaging (NBI) system and magnifying endoscopy allows simple and clear visualization of microscopic structures of the superficial mucosa and its capillary patterns, which may be useful for precise endoscopic diagnosis in the gastrointestinal tract, being more closely to histopathological diagn...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000321799

    authors: Okubo M,Tahara T,Shibata T,Nakamura M,Kamiya Y,Yoshioka D,Maeda Y,Yonemura J,Ishizuka T,Arisawa T,Hirata I

    更新日期:2011-01-01 00:00:00

  • Differential distribution of serotonin and tryptophan hydroxylase in the human gastrointestinal tract.

    abstract::The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007590

    authors: Meyer T,Brinck U

    更新日期:1999-01-01 00:00:00

  • Mucin content in gallbladders with brown pigment stones or combination stones with a brown periphery.

    abstract:BACKGROUND/AIMS:Gallbladder mucus itself has been recognized to play an important role in gallstone development. Despite the diverse mechanisms of stone induction and the differences in stone composition, there is a quantitative increase in the epithelial mucus production period before stone formation. As brown pigment...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007572

    authors: Sheen PC,Lee KT,Liu YE

    更新日期:1998-11-01 00:00:00

  • Serum bile acid levels in children with chronic persistent hepatitis and chronic aggressive hepatitis.

    abstract::A statistical study was carried out to determine if fasting serum bile acid levels are clinically useful in differentiating children with chronic persistent hepatitis from children with chronic aggressive hepatitis. Serum bile acid levels were determined in 27 patients with chronic aggressive hepatitis, 41 with chroni...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198934

    authors: Jara P,Codoceo R,Hernanz A,Castaño C,Diaz C,Montero JL,Vázquez C

    更新日期:1983-01-01 00:00:00

  • Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin.

    abstract:OBJECTIVE:The authors reported that the repair of submucosal tissue is important in ulcer healing. The kinetics of fibroblasts have not been well known in gastric ulcer healing. The effect of subcutaneous administration of indomethacin (1 mg/kg) to submucosal tissue was also examined. METHOD:Immunohistological stainin...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201463

    authors: Hirose Y,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J,Tsukamoto Y

    更新日期:1997-01-01 00:00:00

  • Nutrition in Inflammatory Bowel Disease.

    abstract:BACKGROUND:Westernization, above all associated changes in diet, has been postulated to be one of the most important factors contributing to the increasing incidence in inflammatory bowel disease (IBD), consisting mainly of Crohn's disease and ulcerative colitis. SUMMARY:Diet represents a crucially important and intui...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000505368

    authors: Schreiner P,Martinho-Grueber M,Studerus D,Vavricka SR,Tilg H,Biedermann L,on behalf of Swiss IBDnet, an official working group of the Swiss Society of Gastroenterology.

    更新日期:2020-01-01 00:00:00

  • Effect of gastrin on fasting and postprandial plasma GIP release in man.

    abstract::In order to evaluate the mechanism behind the augmented postprandial gastric inhibitory polypeptide (GIP) release seen in patients with achlorhydria and hypergastrinemia, 8 healthy subjects were given a liquid test meal on three different days. On 1 day the meal was preceded by ranitidine (H2 receptor antagonist) to b...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198815

    authors: Jorde R,Schulz TB,Burhol PG,Waldum HL

    更新日期:1982-01-01 00:00:00

  • Factors relevant to the prognosis of chronic duodenal ulcer.

    abstract::The aim of the study was to define the effects of sex, age, smoking, alcohol, analgesic ingestion, and treatment method whereby healing was initially induced on the prognosis of patients with a chronic duodenal ulcer (DU). 122 patients were assessed 1 year after the endoscopic demonstration of a DU. Two outcome variab...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199171

    authors: Piper DW,McIntosh JH,Hudson HM

    更新日期:1985-01-01 00:00:00

  • Clinical trial: transcutaneous interferential electrical stimulation in individuals with irritable bowel syndrome - a prospective double-blind randomized study.

    abstract:BACKGROUND:The exact etiology of irritable bowel syndrome (IBS) remains unclear. Curative treatment is not available and current treatment modalities are mainly directed against the predominant symptoms. There are a few studies reporting the beneficial effects of transcutaneous electrical stimulation in patients with c...

    journal_title:Digestion

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000338301

    authors: Coban Ş,Akbal E,Köklü S,Köklü G,Ulaşlı MA,Erkeç S,Aktaş B,Yüksel O,Koçak E,Erdem HR

    更新日期:2012-01-01 00:00:00

  • Variable effect of lithium on canine pancreatic polypeptide and gastrin release by a meal or bombesin.

    abstract::Lithium is a cation which has central nervous system effects and is able to interfere with both the release and action of polypeptide hormones. We examined its effect on basal and stimulated plasma gastrin and pancreatic polypeptide (PP) levels in 4 dogs with chronic gastric fistulas. Gastrin and PP release were stimu...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198642

    authors: Modlin IM,Ehrlich BE,Lamers CB,Diamond JM,Walsh JH

    更新日期:1981-01-01 00:00:00

  • What determines the later clinical course of patients who do not undergo colectomy at the first attack? A Japanese cohort study on ulcerative colitis.

    abstract:BACKGROUND/AIMS:Several earlier studies on factors predicting the long-term outcome of ulcerative colitis only encompassed treatment failure for one severe episode, or suffered from a lack of multivariate analyses. We aimed to identify factors assessable at diagnosis or after the first induction therapy which predicted...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000229773

    authors: Shiga H,Takagi S,Inoue R,Kinouchi Y,Ohkubo T,Takahashi S,Negoro K,Yokoyama H,Kato S,Fukushima K,Hiwatashi N,Shimosegawa T

    更新日期:2010-01-01 00:00:00

  • Reduced expression of epidermal growth factor receptor-related protein in hepatocellular carcinoma: implications for cancer growth.

    abstract:BACKGROUND/AIMS:The mitogenic signaling pathway of epidermal growth factor receptor (EGFR) is activated in a variety of cancers, including hepatocellular carcinoma (HCC). The recently cloned EGFR-related protein (ERRP) has been proposed to be a negative regulator of EGFR. The expression of ERRP in non-malignant liver c...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000079151

    authors: Moon WS,Chang KJ,Majumdar AP,Tarnawski AS

    更新日期:2004-01-01 00:00:00

  • A critical assessment of the current status of non-erosive reflux disease.

    abstract::Non-erosive reflux disease (NERD) has assumed increasing prominence in studies of gastroesophageal reflux disease (GERD), but it remains a challenge to define NERD precisely and to define its place in the investigation and treatment of GERD. Most simply, NERD may be defined as GERD in an individual who has no evidence...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000151255

    authors: Armstrong D

    更新日期:2008-01-01 00:00:00

  • Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules.

    abstract:BACKGROUND AND AIMS:Supramaximal concentrations of cholecystokinin (CCK) or cerulein induce the intracellular activation of trypsinogen and the transcription factor NF-kappaB, a key regulator of inflammatory gene expression. Both events occur early in the development of an acute pancreatitis. The aim of this study was ...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000068364

    authors: Tando Y,Algül H,Schneider G,Weber CK,Weidenbach H,Adler G,Schmid RM

    更新日期:2002-01-01 00:00:00

  • Comparison of the small bowel motor response to solid and liquid meals in man.

    abstract::Interdigestive motor activity has been studied extensively both in the human and canine small intestine. The more irregular postprandial pattern, however, has rarely been studied. In particular, physiological studies in humans are lacking. Thus it is unknown whether the physical state of a meal affects the duration of...

    journal_title:Digestion

    pub_type: 临床试验,杂志文章

    doi:10.1159/000201474

    authors: v Schönfeld J,Evans DF,Goebell H,Wingate DL

    更新日期:1997-01-01 00:00:00

  • Apparent post-transcriptional modification of ornithine decarboxylase accounts for its induction in IEC-6 cells in culture.

    abstract::Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000200412

    authors: Seidel ER,Ginty DD

    更新日期:1990-01-01 00:00:00

  • Effect of chenodeoxycholic acid on liver structure and function in man: a stereological and biochemical study.

    abstract::Chenodeoxycholic acid (CDCA) is an effective treatment for dissolving gallstones but experimental studies have suggested that it might be hepatotoxic. The present study is concerned with a group of patients undergoing medical therapy for gallstones for periods of 30 days up to 14 months with CDCA (15 mg/kg/day). Routi...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198409

    authors: Koch MM,Giampieri MP,Lorenzini I,Jezequel AM,Orlandi F

    更新日期:1980-01-01 00:00:00

  • A rapid method of relating protein to flow in human pancreatic secretions.

    abstract::A method of obtaining linear plots of protein-flow data from human pancreatic ductal secretions is described. The protein concentration in pancreatic secretions, when related to flow rates in two individuals, gave similar regression lines, with the correlation coefficients or r = -0.97 and -0.98, respectively, and slo...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000197922

    authors: Allan BJ,White TT

    更新日期:1976-01-01 00:00:00

  • Radioisotope-guided surgery in patients with neuroendocrine tumours.

    abstract::We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201406

    authors: Ahlman H

    更新日期:1996-01-01 00:00:00

  • Hesperidin Improves Colonic Motility in Loeramide-Induced Constipation Rat Model via 5-Hydroxytryptamine 4R/cAMP Signaling Pathway.

    abstract::Fructus has motivation effect on gastrointestinal tract. Hesperidin is extracts of Fructus, and we attempted to prove its effects on improving the gastrointestinal transmission function and determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. Constipation phenotypes were mea...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000501959

    authors: Wu M,Li Y,Gu Y

    更新日期:2020-01-01 00:00:00

  • The c.1-260C>T promoter variant of CD14 but not the c.896A>G (p.D299G) variant of toll-like receptor 4 (TLR4) genes is associated with inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) results from an aberrant immune response to the indigenous intestinal flora in genetically susceptible hosts. Therefore, the study of candidate genes involved in host pathogen interactions is of key interest. METHODS:In this two-center, retrospective German and Hungarian coh...

    journal_title:Digestion

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000112646

    authors: Baumgart DC,Buning C,Geerdts L,Schmidt HH,Genschel J,Fiedler T,Gentz E,Molnar T,Nagy F,Lonovics J,Lochs H,Wiedenmann B,Nickel R,Witt H,Dignass A

    更新日期:2007-01-01 00:00:00

  • Effect of fasting on diarrhoea in collagenous colitis.

    abstract:BACKGROUND/AIM:Diarrhoea in collagenous colitis has been considered as secretory though the pathophysiology has been studied thoroughly in only a few patients. The result of fasting is one way to distinguish between secretory and osmotic diarrhoea. Our aim was to investigate the effect of fasting on diarrhoea in collag...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051928

    authors: Bohr J,Järnerot G,Tysk C,Jones I,Eriksson S

    更新日期:2002-01-01 00:00:00

  • Argyrophil cell hyperplasia of fundic mucosa in patients with chronic atrophic gastritis.

    abstract::Eighteen cases of severe hyperplasia of fundic argyrophil cells observed during routine histologic examination of endoscopic gastric biopsy specimens from unselected patients with upper gastro-intestinal symptomatology were investigated. All patients, except one, were female with a mean age of 57 years. Atrophic gastr...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199389

    authors: Bordi C,Pilato F,Carfagna G,Ferrari C,D'Adda T,Sivelli R,Bertelé A,Missale G

    更新日期:1986-01-01 00:00:00