Fate of pancreatic enzymes in the human intestinal lumen in health and pancreatic insufficiency.

abstract：:The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...

journal_title：Digestion

authors： Sjövall M,Lindstedt G,Olbe L,Lundell L

更新日期：1992-01-01 00:00:00

abstract：:Glycoprotein and protein production of isolated pig gastric mucosal cells were determined by the incorporation of N-acetyl-[14C]D-glucosamine ([14C]GlcNAc) and [3H]L-leucine ([3H]Leu) into acid-insoluble macromolecules (AIM). In four cell fractions (F1-F4), obtained by counterflow centrifugation, specific [14C]GlcNAc ...

journal_title：Digestion

authors： Heim HK,Oestmann A,Thiele H,Sewing KF

更新日期：1989-01-01 00:00:00

abstract：:It is now generally admitted that phytohemagglutinin (PHA) constitutes the main factor responsible for the dietary toxicity of raw kidney beans. In the growing rat, an impairment of growth is the unique expression of a malnutrition syndrome. The aim of this work was to precise to what extent the intestinal injuries ma...

journal_title：Digestion

authors： Lafont J,Rouanet JM,Gabrion J,Assouad JL,Zambonino Infante JL,Besançon P

更新日期：1988-01-01 00:00:00

abstract：:Putrescine, the product of the ornithine decarboxylase (ODC)-catalyzed reaction, stimulates macromolecular synthesis in a duodenal crypt cell line, IEC-6 cells, grown in culture. In addition, supplementation of medium with putrescine alone reverses the inhibition of proliferation produced by inhibition of ODC with dif...

journal_title：Digestion

authors： Seidel ER,Ginty DD

更新日期：1990-01-01 00:00:00

abstract：:D-Galactosamine administration to rats (400 mg/kg) by intraperitoneal injection induced biochemical alterations in liver plasma membranes. Alterations were studied 4, 16 and 24 h after D-galactosamine injection. Plasma membrane 5'-mononucleotidase activity decreased to 40% of control values. Carbohydrate composition w...

journal_title：Digestion

authors： Bertrand F,Veissiere D,Picard J

更新日期：1979-01-01 00:00:00

abstract：:Functional changes of the exocrine pancreas in cerulein-induced pancreatitis were evaluated with the isolated perfused rat pancreas. In control specimens (n = 7), baseline pancreatic juice volume was 0.23 +/- 0.06 microliter/min and after stimulation with CCK-8 (10(-10) M) and secretin (10(-10) M), it was 2.26 +/- 0.4...

journal_title：Digestion

authors： Ando K,Manabe T,Kyogoku T,Ohshio G,Yotsumoto F,Tamura K,Imanishi K,Yositomi S,Tobe T

更新日期：1992-01-01 00:00:00

abstract：:This study was undertaken to evaluate the effect of metoclopramide on transmural oesophageal variceal pressure and portal blood flow in cirrhotic patients. Sixteen cirrhotics were randomly assigned to metoclopramide (10 mg i.v.) or saline. Metoclopramide significantly decreased transmural variceal pressure (15.7% decr...

journal_title：Digestion

authors： Taranto D,Suozzo R,de Sio I,Romano M,Caporaso N,Del Vecchio Blanco C,Coltorti M

更新日期：1990-01-01 00:00:00

abstract：:Patients with moderate-to-severe disease and patients with steroid-refractory or steroid-dependent disease differ in their management, as the latter two groups usually involve patients whose condition is less acute. Systemic corticosteroids represent the mainstay of the management of moderate-to-severe disease and rem...

journal_title：Digestion

authors： Michetti P,Mottet C,Juillerat P,Pittet V,Felley C,Vader JP,Gonvers JJ,Froehlich F

更新日期：2007-01-01 00:00:00

abstract：:Isolated acinar cells from rat pancreas responded well to hormonal treatment. Both secretin (synthetic and highly purified from porcine origin) and CCK-octapeptide stimulated amylase secretion in these cells. The response in both cases was very rapid. A maximal output of enzyme was reached within 5-10 min after the ad...

journal_title：Digestion

authors： Lee PC

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND/AIM:What naturally happens to patients after they undergo conservative and endoscopic treatment of colonic diverticular bleeding (CDB) is largely unknown. We retrospectively track the long-term outcome of the recurrence of CDB between patients with endoscopic and conservative treatment. METHODS:The group wa...

journal_title：Digestion

authors： Mizuki A,Tatemichi M,Nakazawa A,Tsukada N,Nagata H,Kanai T

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The changes in gastroesophageal reflux disease (GERD)-related symptoms on treatment are variously described, but currently available questionnaires have shortcomings. We therefore developed a self-assessment reflux questionnaire (ReQuest). This article describes the process of development and testing. ...

journal_title：Digestion

authors： Bardhan KD,Stanghellini V,Armstrong D,Berghöfer P,Gatz G,Mönnikes H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Prevention of Helicobacter pylori infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no immunization protocol has been accepted for humans. A better characterization of the i...

journal_title：Digestion

authors： Lazowska I,Trzeciak L,Godlewska R,Hennig E,Jagusztyn-Krynicka K,Popowski J,Regula J,Ostrowski J

更新日期：2000-01-01 00:00:00

abstract：:The activity of platelet-activating factor (PAF) acetylhydrolase in biopsy specimens of intestinal mucosa was compared in patients with Crohn's disease (n = 11) and controls (n = 6). In addition, PAF acetylhydrolase activity was determined in the plasma of Crohn patients (n = 30) and healthy subjects (n = 35). The act...

journal_title：Digestion

authors： Kald B,Smedh K,Olaison G,Sjödahl R,Tagesson C

更新日期：1996-11-01 00:00:00

abstract：:The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...

journal_title：Digestion

authors： Tanikawa M,Hayakawa T,Kondo T,Naruse S,Shibata T,Kitagawa M

更新日期：1994-01-01 00:00:00

abstract：:Chemiluminescence (CL) is a simple quantitative assay of polymorphonuclear leucocyte (PMNL) oxidative metabolism. PMNL CL was found to be significantly higher in patients with chronic inflammatory bowel disease than in normal controls (167 +/- 60 vs. 139 +/- 50 mV/10(5) cells, p less than 0.05). There were no signific...

journal_title：Digestion

authors： Kelleher D,Feighery C,Weir DG

更新日期：1990-01-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the risk factors associated with the occurrence of acute hepatic failure following transcatheter arterial embolization (TAE) for hepatocellular carcinoma. From 1984 to 1993 we performed a total of 623 embolization procedures in 369 patients with both hepatocellular car...

journal_title：Digestion

authors： Katsushima S,Inokuma T,Oi H,Okamura J,Higashi T,Takeuchi R,Hidaka A,Shigeno C,Iida Y,Konishi J

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:To identify the number and potential causes of unnecessary diagnostic procedures in a cohort of patients with autoimmune pancreatitis (AIP). METHODS:All AIP cases at our centre between April 2006 and April 2013 were collected and followed up. Diagnosis was established by the International Consensus Dia...

journal_title：Digestion

authors： Manser CN,Gubler C,Müllhaupt B,Bauerfeind P

更新日期：2015-01-01 00:00:00

abstract：:We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...

journal_title：Digestion

authors： Ahlman H

更新日期：1996-01-01 00:00:00

abstract：AIMS:The primary objective of this study was to clarify the influence of histotype on the outcome of D1/D2 gastrectomized patients with pathologically proven R0 resection. The secondary objective was to demonstrate overall survival (OS), disease-free survival (DFS), and locoregional recurrence rates following standard ...

journal_title：Digestion

authors： Uslu A,Bati H,Postaci H,Nart A,Eliyatkin N,Yetis H,Corumlu B,Aykas A,Zengel B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate whether the neuronal form of nitric oxide (NO) synthase (nNOS) in gastric mucosa differed from nNOS in the brain in subcellular distribution or antigenicity, and to determine the relative activity of the endothelial form of NO synthase (eNOS) and nNOS in gastric mucosa. METHODS:Subcellul...

journal_title：Digestion

authors： Price K,Hanson P

更新日期：1998-07-01 00:00:00

abstract：AIMS:We investigated the effect of n-3 polyunsaturated fatty acids (PUFAs) on mucosal levels of leukotrienes (LTs) and lipid peroxide (LPO), and on mucosal microcirculation, in rats with experimental colitis induced by dextran sulfate sodium (DSS). METHODS:We fed Wistar rats a perilla oil-enriched diet containing alph...

journal_title：Digestion

authors： Shimizu T,Igarashi J,Ohtuka Y,Oguchi S,Kaneko K,Yamashiro Y

更新日期：2001-01-01 00:00:00

abstract：:Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled. In this study performed on 16 young male subjects, gastric acid secretion and emptying rate were determined after intragastric administration of 8% pep...

journal_title：Digestion

authors： Konturek SJ,Kwiecien N,Obtulowicz W,Kopp B,Oleksy J,Rovati L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIMS:The benefits of colonoscopy in reducing colorectal cancer (CRC) risk for patients over 75 years are controversial. We aimed to determine whether colonoscopy use is associated with a decreased risk of CRC in patients 76-85 years old in the United States (US). PATIENTS AND METHODS:All patients in the Med...

journal_title：Digestion

authors： Wang YR,Cangemi JR,Loftus EV Jr,Picco MF

更新日期：2016-01-01 00:00:00

abstract：:Studies with short-term administration of omeprazole in patients with erosive or ulcerative reflux oesophagitis have demonstrated that strong inhibition of gastric acid secretion will become the therapy of choice for these patients. However, because reflux oesophagitis relapses rapidly when short-term treatment is dis...

journal_title：Digestion

authors： Jansen JB,Lamers CB

更新日期：1989-01-01 00:00:00

abstract：:The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the infection is especially i...

journal_title：Digestion

authors： Tytgat GN

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVES:Recently, several studies have demonstrated the usefulness of endoscopic submucosal dissection (ESD) for residual or locally recurrent colorectal lesions after endoscopic treatment. However, the feasibility of ESD for recurrent rectal lesions after transanal endoscopic microsurgery (TEM) has not been fully i...

journal_title：Digestion

authors： Ikezawa N,Toyonaga T,Tanaka S,Nakano Y,Ishida T,Yoshihara T,Uraoka M,Morita Y,Suzuki N,Haji A,Kodama Y

更新日期：2020-02-05 00:00:00

abstract：:Zinc nutriture has been studies in 30 patients with Crohn's disease using plasma zinc, hair zinc, and taste acuity as indices. Significant reductions in plasma zinc concentrations and taste acuity were seen in the patient groups as compared with normal controls. Hair zinc content was also generally low with several de...

journal_title：Digestion

authors： Solomons NW,Rosenberg IH,Sandstead HH,Vo-Khactu KP

更新日期：1977-01-01 00:00:00

abstract：:We have previously shown a specific significant overexpression in the exocrine pancreatic tissue of two members of the regenerating gene multifamily: reg I and reg II in the non-obese diabetic (NOD) mouse during active diabetogenesis. To strengthen the hypothesis that the overexpression of these genes may represent a ...

journal_title：Digestion

authors： Baeza N,Sanchez D,Christa L,Guy-Crotte O,Vialettes B,Figarella C

更新日期：2001-01-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis represent distinct phenotypic forms of inflammatory bowel disease and continue to be a common cause of morbidity. The corticosteroids and the immunomodulatory drugs, which are the basis of treatment for the inflammatory bowel diseases, do not assure always satisfactory outcomes. ...

journal_title：Digestion

authors： Ioannidis O,Varnalidis I,Paraskevas G,Botsios D

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Colonic motility disorders are a frequent clinical problem caused by various drugs and diseases. However, the etiology of colonic dysmotility is often unclear due to the lack of in vivo methods, including rapid dynamic assessment. OBJECTIVES:The aim of this study was to establish a novel quantitative meth...

journal_title：Digestion

authors： Kishi K,Kaji N,Tsuru Y,Hori M

更新日期：2020-12-01 00:00:00