Radioisotope-guided surgery in patients with neuroendocrine tumours.

Abstract:

:We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between measurements was calculated for 23 patients with neuroendocrine tumours. The count rates of excised tumour and normal tissue were also measured ex vivo and their ratio R(ex vivo) was calculated. In midgut carcinoid (MC) patients (all scintigraphy positive), 4/29 macroscopically identified tumours gave false R(in situ). Tumour/blood 111In activity (T/B) ratios measured in a gamma counter were all high (27-650). In patients with medullary thyroid carcinoma (8/10 scintigraphy positive), misleading R(in situ) were found in 4/37 macroscopically identified tumours. T/B ratios were lower (3-39) than those seen in MC patients. 2/4 patients with endocrine pancreatic tumours (EPTs) had positive scintigraphy, reliable intra-operative measurements, and very high T/B ratios (910-1,500). 1 patient with a gastric carcinoid had correct R(in situ) and R(ex vivo), with high T/B ratios (71-210). 1 patient with sporadic insulinoma had negative scintigraphy and 1 patient with neuroendocrine carcinoma of the uterus also had low T/B ratios. In most cases, in situ measurements added little information to preoperative scintigraphy and surgical findings. The very high T/B ratios seen in MC tumours and some EPTs seem promising for future radiotherapy via somatostatin receptors.

journal_name

Digestion

journal_title

Digestion

authors

Ahlman H

doi

10.1159/000201406

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

88-9

eissn

0012-2823

issn

1421-9867

journal_volume

57 Suppl 1

pub_type

杂志文章
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    authors: Chu M,Rehfeld JF,Borch K

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2017-01-01 00:00:00

  • Stimulation of disaccharidase activities in the jejunal brush border membrane of adult rat by total parenteral nutrition. Effects of thyroid hormones.

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    pub_type: 杂志文章

    doi:10.1159/000199030

    authors: Raul F,Galluser M,Doffoel M

    更新日期:1984-01-01 00:00:00

  • Edkins and a century of acid suppression.

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    journal_title:Digestion

    pub_type: 传,历史文章,杂志文章

    doi:10.1159/000088368

    authors: Modlin IM,Sachs G,Wright N,Kidd M

    更新日期:2005-01-01 00:00:00

  • Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000496102

    authors: Kashiwagi S,Naito Y,Inoue R,Takagi T,Nakano T,Inada Y,Fukui A,Katada K,Mizushima K,Kamada K,Uchiyama K,Handa O,Ishikawa T,Itoh Y

    更新日期:2020-01-01 00:00:00

  • Limited heat-shock protein 72 induction in Caco-2 cells by L-glutamine.

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    journal_title:Digestion

    pub_type: 杂志文章

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    authors: Lindemann G,Grohs M,Stange EF,Fellermann K

    更新日期:2001-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    authors: Eckel F,Lersch C,Huber W,Weiss W,Berger H,Schulte-Frohlinde E

    更新日期:2000-01-01 00:00:00

  • Kinetics of fibroblasts in ulcer healing in rats: interference with indomethacin.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201463

    authors: Hirose Y,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J,Tsukamoto Y

    更新日期:1997-01-01 00:00:00

  • Mucin content in gallbladders with brown pigment stones or combination stones with a brown periphery.

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    pub_type: 杂志文章

    doi:10.1159/000007572

    authors: Sheen PC,Lee KT,Liu YE

    更新日期:1998-11-01 00:00:00

  • Argon plasma coagulation of gastric inlet patches for the treatment of globus sensation: it is an effective therapy in the long term.

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    pub_type: 杂志文章

    doi:10.1159/000355274

    authors: Klare P,Meining A,von Delius S,Wolf P,Konukiewitz B,Schmid RM,Bajbouj M

    更新日期:2013-01-01 00:00:00

  • Effect of filtrate containing Clostridium difficile toxin on rectal mucosa maintained in organ culture.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199212

    authors: Allan A,Jewell DP

    更新日期:1985-01-01 00:00:00

  • Differential distribution of serotonin and tryptophan hydroxylase in the human gastrointestinal tract.

    abstract::The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000007590

    authors: Meyer T,Brinck U

    更新日期:1999-01-01 00:00:00

  • Pharmacodynamic effects of Sandostatin in the gastrointestinal tract.

    abstract::Somatostatin is widely distributed throughout the human gastrointestinal system. There it is found in neurons and fibers of both the submucosal and the myenteric plexus and the pancreas as well as in the D cells of the stomach, gut and pancreatic islets. Whereas in the intestinal nervous system, in the duodenum and th...

    journal_title:Digestion

    pub_type: 杂志文章,评审

    doi:10.1159/000201070

    authors: Gyr KE,Meier R

    更新日期:1993-01-01 00:00:00

  • Safety experience from long-term treatment with omeprazole.

    abstract::Omeprazole was administered for up to 6 years in 859 patients for 'prevention of relapse in patients with poorly responsive peptic ulcer or reflux oesophagitis'. The pattern of adverse events reported during long-term treatment was similar to the adverse-event profile in short-term treatment with omeprazole (n = 2,818...

    journal_title:Digestion

    pub_type: 杂志文章,meta分析

    doi:10.1159/000200922

    authors: Joelson S,Joelson IB,Lundborg P,Walan A,Wallander MA

    更新日期:1992-01-01 00:00:00

  • Effects of pirenzepine and atropine on amylase response to various secretagogues from the rat pancreatic acini.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199415

    authors: Jaworek J,Konturek SJ

    更新日期:1987-01-01 00:00:00

  • Inhibitory effect of somatostatin on cholera toxin-induced diarrhea and glycoenzyme secretion in rat intestine.

    abstract::The effects of somatostatin on cholera toxin-induced secretory diarrhea and the appearance of glycoenzymes in the intestinal lumen and intestinal lymph were investigated in rat small intestine. After exposure to cholera toxin, marked fluid accumulation in the small intestinal tract and elevation of the jejunal mucosal...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000199411

    authors: Yoshioka M,Asakura H,Hamada Y,Miura S,Kobayashi K,Morishita T,Morita A,Tsuchiya M

    更新日期:1987-01-01 00:00:00

  • The utility of cellulose meals for studies on gastrointestinal motility in dogs.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198829

    authors: Schemann M,Ehrlein HJ

    更新日期:1982-01-01 00:00:00

  • Existence of variant gamma delta T cells in Crohn's disease.

    abstract:BACKGROUND AND OBJECTIVES:gamma delta T cell populations are well-known for their unique distribution (e.g. intra-epithelial lymphocytes). Though their ligands play a major role in the immune response they have remained largely obscure. To shed light on this issue, we have analyzed in this study the complementarity det...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000051911

    authors: Ishiguro Y,Kanazawa H,Yamagata K,Sakuraba H,Munakata A

    更新日期:2001-01-01 00:00:00

  • Direct inhibition of gastrointestinal carbonic anhydrase by ethanol.

    abstract::Carbonic anhydrase (CA) was found to be equally susceptible to direct inhibition by ethanol, whether the enzyme originated from homogenates of rabbit gastric, duodenal, or ileal mucosa. When gastric mucosa was separated into a soluble (cytoplasmic) and a membrane fraction, the membrane CA was more susceptible to ethan...

    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198130

    authors: Newsome LR,Leitch GJ

    更新日期:1978-07-01 00:00:00

  • Distribution of hepatic nerve fibers in liver diseases.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000201156

    authors: Jaskiewicz K,Voigt MD,Robson SC

    更新日期:1994-01-01 00:00:00

  • Effect of cycloheximide on bile flow adaptive response in selective biliary obstruction.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000198431

    authors: Mackinnon M,Kohler M

    更新日期:1980-01-01 00:00:00

  • Predictors for Complicated Disease Course after Stepping Down from Combination to Antitumor Necrosis Factor Alpha Monotherapy in Children with Inflammatory Bowel Disease.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000496273

    authors: Yerushalmy-Feler A,Moran-Lev H,Galai T,Cohen S

    更新日期:2020-01-01 00:00:00

  • Correlation of gut hormones with irritable bowel syndrome.

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    journal_title:Digestion

    pub_type: 杂志文章

    doi:10.1159/000165352

    authors: Zhang H,Yan Y,Shi R,Lin Z,Wang M,Lin L

    更新日期:2008-01-01 00:00:00

  • Mild pancreatic damage in acute viral hepatitis.

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    pub_type: 杂志文章

    doi:10.1159/000199831

    authors: Taranto D,Carrato A,Romano M,Maio G,Izzo CM,Del Vecchio Blanco C

    更新日期:1989-01-01 00:00:00

  • Value of prealbumin plasma levels as liver test.

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    pub_type: 杂志文章

    doi:10.1159/000199471

    authors: Rondana M,Milani L,Merkel C,Caregaro L,Gatta A

    更新日期:1987-01-01 00:00:00

  • Virus-associated receptors for polymerized human serum albumin (RpHSA) in patients with chronic active hepatitis B treated with recombinant leukocyte A interferon.

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    pub_type: 杂志文章

    doi:10.1159/000199474

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    更新日期:1987-01-01 00:00:00